A5056218764- Spectroscopy Techniques in Biomedical and Chemical Research
- Brain Tumor Detection and Classification
- Digital Imaging for Blood Diseases
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Management of metastatic bone disease
- Spine and Intervertebral Disc Pathology
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Neurofibromatosis and Schwannoma Cases
- Molecular Biology Techniques and Applications
- Cell Image Analysis Techniques
- Kruppel-like factors research
- Gestational Trophoblastic Disease Studies
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Spinal Hematomas and Complications
- RNA modifications and cancer
- Medical Imaging and Analysis
- Cancer-related molecular mechanisms research
- AI in cancer detection
University Hospital Cologne
2017-2024
University of Cologne
2017-2024
University of Duisburg-Essen
2024
Brigham and Women's Hospital
2019-2022
Harvard University
2019-2022
University Hospital Magdeburg
2022
Massachusetts Institute of Technology
2020-2021
Otto-von-Guericke University Magdeburg
2020-2021
LVR-Klinik Köln
2016
Universität Hamburg
2016
The intrinsic autofluorescence of biological tissues interferes with the detection fluorophores administered for fluorescence guidance, an emerging auxiliary technique in oncological surgery. Yet, human brain and its neoplasia is sparsely examined. This study aims to assess on a microscopic level by stimulated Raman histology (SRH) combined two-photon fluorescence.With this experimentally established label-free microscopy unprocessed tissue can be imaged analyzed within minutes process...
Abstract Determining the presence of tumor in biopsies and decision-making during resections is often dependent on intraoperative rapid frozen-section histopathology. Recently, stimulated Raman scattering microscopy has been introduced to rapidly generate digital hematoxylin-and-eosin-stained-like images (stimulated histology) for analysis. To enable prediction presence, we aimed develop a new deep residual convolutional neural network an automated pipeline tested its validity. In...
Recent artificial intelligence algorithms aided intraoperative decision-making via stimulated Raman histology (SRH) during craniotomy. This study assesses deep learning for rapid diagnosis from SRH images in small stereotactic-guided brain biopsies. It defines a minimum tissue sample size threshold to ensure diagnostic accuracy.
Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations meningioma have been identified and correlated with certain pathological subtypes, locations clinical observations. Alterations of cellular pathways due to these mutations, however, largely remained elusive. Here we report that Krueppel like factor 4 (KLF4)-K409Q mutation skull base meningiomas triggers a distinct phenotype. Transcriptomic analysis 17 samples revealed KLF4K409Q mutated...
Effective delivery to the brain limits development of novel glioblastoma therapies. Here, we introduce conjugation between platinum(IV) prodrugs cisplatin and perfluoroaryl peptide macrocycles increase uptake. We demonstrate that one such conjugate shows efficacy against glioma stem-like cells. investigate pharmacokinetics this in mice show amount platinum after treatment with is 15-fold greater than 5 h.
Background: Adequate assessment of spinal instability using the neoplastic score (SINS) frequently guides surgical therapy in epidural osseous metastases and subsequently influences neurological outcome. However, how to surgically manage ‘impending instability’ at SINS 7–12 most appropriately remains uncertain. This study aimed evaluate necessity instrumentation patients with regards Methods: We screened 683 treated our interdisciplinary spine center. The preoperative was assessed determine...
Glioblastoma (GBM) is the most common and deadliest malignant primary brain tumor, contributing significant morbidity mortality among patients. As current standard-of-care demonstrates limited success, development of new efficacious GBM therapeutics urgently needed. Major challenges in advancing chemotherapy include poor bioavailability, lack tumor selectivity leading to undesired side effects, permeability across blood-brain barrier (BBB), extensive intratumoral heterogeneity. We have...
Timely aneurysm occlusion and neurointensive care treatment are key principles in the management of aneurysmal subarachnoid hemorrhage (aSAH) to prevent secondary brain injury. Patients with early (EHA) delayed hospital admission (DHA) were compared terms clinical presentation, strategies, aSAH-related complications, outcome.In this retrospective study, consecutive aSAH patients treated at a single neurovascular center between 2009 2019. Propensity score matching was performed account for...
Abstract Glioblastoma (GBM) is the most common and deadliest form of brain tumor remains amongst difficult cancers to treat. Brevican (Bcan), a central nervous system (CNS)‐specific extracellular matrix protein, upregulated in high‐grade glioma cells, including GBM. A Bcan isoform lacking glycosylation, dg‐Bcan, found only GBM tissues. Here, dg‐Bcan explored as molecular target for In this study, d ‐peptide library screened identify small 8‐amino acid dg‐ B can‐ T argeting P eptide (BTP)...
Cranioplasty (CP) is a crucial procedure after decompressive craniectomy and has significant impact on neurological improvement. Although CP considered standard neurosurgical procedure, inconsistent data surgery-related complications are available. To address this topic, the authors analyzed 502 patients in prospective multicenter database (German Cranial Reconstruction Registry) with regard to early complications.
Surgical treatment is an integral component of multimodality management metastatic spine disease but must be balanced against the risk surgery-related morbidity and mortality, making tailored surgical counseling a clinical challenge. The aim this study was to investigate potential predictive value preoperative performance status for outcome in patients with spinal metastases.
<div>AbstractPurpose:<p>Recent artificial intelligence algorithms aided intraoperative decision-making via stimulated Raman histology (SRH) during craniotomy. This study assesses deep learning for rapid diagnosis from SRH images in small stereotactic-guided brain biopsies. It defines a minimum tissue sample size threshold to ensure diagnostic accuracy.</p>Experimental Design:<p>A prospective single-center examined 121 84 patients with unclear intracranial lesions...
Background Cerebrospinal fluid leakage (CSFL) following spinal durotomy can lead to severe sequelae. However, while several studies have investigated accidental durotomies, the risk factors and influence of clinical management in planned durotomies remain unclear. Methods We performed a retrospective analysis all patients who underwent intradural surgery at our institution between 2010 2020. Depending on occurrence CSFL, were dichotomized compared with respect patient case-related variables...
The current neurosurgical intervention for treatment of acute epidural hematoma (AEDH) usually involves a craniotomy. Despite its effectiveness, open surgical decompression has several limitations. twist intraosseous drill needle (TIDN) is considered feasible alternative in adult patients with AEDH. AEDH TIDN pediatric not yet been described. study aimed to report the efficacy and safety minimally invasive puncture combined drainage patients.We retrospectively collected medical records...