A5030993533- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Folate and B Vitamins Research
- Iron Metabolism and Disorders
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Hemoglobinopathies and Related Disorders
- Radiomics and Machine Learning in Medical Imaging
- Hormonal Regulation and Hypertension
- Lung Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Medical Imaging Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Pain Management and Treatment
- Renal Transplantation Outcomes and Treatments
- Alcohol Consumption and Health Effects
- Adrenal Hormones and Disorders
- Radiation Dose and Imaging
- Urinary and Genital Oncology Studies
- Organ Donation and Transplantation
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Treatments and Mutations
University Medical Center Freiburg
2020-2024
University of Freiburg
2020-2024
Stanford University
2024
Heidelberg University
2018-2019
University Hospital Heidelberg
2018-2019
Diagnosing myocarditis relies on multimodal data, including cardiovascular magnetic resonance (CMR), clinical symptoms, and blood values. The correct interpretation integration of CMR findings require radiological expertise knowledge. We aimed to investigate the performance Generative Pre-trained Transformer 4 (GPT-4), a large language model, for report-based medical decision-making in context cardiac MRI suspected myocarditis.
Abstract Obesity is characterized by the accumulation of adipose tissue in different body compartments. Whether directly affects kidney function still unknown. We aimed to investigate role and circulating creatinine, cystatin C subjects free cardio-renal diseases. In KORA-MRI population-based study, 377 (mean age 56.2 ± 9.2 years; 41.6% female) underwent whole-body 3T-MRI examination. Adipose defined as visceral (VAT) subcutaneous (SAT) were quantified from T1-DIXON sequence using a...
Obesity increases the risk of cardiovascular diseases (CVD), however, whether adipose tissue relates to dyslipidemia, and consequently events remains unknown. Thus, we investigated association with circulating lipoproteins triglycerides (TG) in subjects without CVD. 384 participants from KORA-MRI study (mean age 56.2 ± 9.2 years; 41.9% female) underwent whole-body 3T-MRI. Visceral (VAT) subcutaneous (SAT) derived T1-DIXON-sequence using a semi-automatic algorithm. Total cholesterol,...
The aim of this study was to assess adrenal gland volume by using magnetic resonance imaging (MRI) and its role as an indirect marker impaired glucose metabolism hypothalamic-pituitary-adrenal (HPA) axis activation in a population-based cohort.Asymptomatic participants were enrolled nested case-control underwent 3-T MRI, including T1w-VIBE-Dixon sequences. For the assessment volume, glands manually segmented blinded fashion. Impaired determined fasting oral tolerance test. Cardiometabolic...
Non-alcoholic fatty liver disease (NAFLD) represents a major burden in the population. While bidirectional association between NAFLD and diabetes is established, little known about of hepatic iron content glycaemia. Moreover, analyses sex-specific effects dynamic changes glycaemia are scarce.We investigated 7-year trajectories related traits (HbA1c, fasting glucose, insulin, HOMA-IR, 2-h glucose cross-sectional insulin) sample from population-based cohort (N = 365; 41.1% female). Hepatic fat...
Reproducible image quality is of high relevance for large cohort studies and can be challenging magnetic resonance imaging (MRI). Automated assessment may contribute to conducting radiologic effectively.The aims this study were assess protocol repetition frequency in population-based whole-body MRI along with its effect on examination time examine the applicability automated predicting decision-making regarding repeated acquisitions.All participants enrolled prospective, multicenter German...
Abstract To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 underwent whole-body spirometry as part KORA-FF4 cohort study. Lung semi-automatically using an in-house algorithm. Forced expiratory volume one second (FEV1), forced vital capacity (FVC), residual were measured. Cardiac parameters Cine-SSFP-sequence cvi42, while left ventricle (LV)...
Diabetes mellitus is an established risk factor for cardiovascular diseases. Even impaired levels of glucose and insulin might harm organ function prior to diabetes onset. Whether serum or plays a direct role in cardiac dysfunction lung volume reduction remains unclear. The aim was investigate the relationship between with right ventricle volumes within KORA-MRI FF4 study.From cohort study 337 subjects (mean age 55.7 ± 9.1 years; 43% women) underwent whole-body 3T MRI scan. Cardiac...
Abstract Aim of this study was to analyse the associations cardiovascular health and adrenal gland volume as a rather new imaging biomarker chronic hypothalamic–pituitary–adrenal (HPA) axis activation. The population originates from KORA population-based cross-sectional prospective cohort. 400 participants without known disease underwent whole-body MRI. Manual segmentation glands performed on VIBE-Dixon gradient-echo sequence. MRI based evaluation cardiac parameters achieved...
Iron-related disorders of the liver can result in serious health conditions, such as cirrhosis. Evidence on role modifiable lifestyle factors like nutrition iron storage is lacking. Thus, we aimed to assess association habitual diet with content (LIC). We investigated 303 participants from population-based KORA-MRI study who underwent whole-body magnetic resonance imaging (MRI). Dietary habits were evaluated using repeated 24 h food lists and a frequency questionnaire. Sex-stratified...
Hepatic iron overload can cause severe organ damage; therefore, an early diagnosis and the identification of potential risk factors is crucial. We aimed to investigate sex-specific distribution hepatic content (HIC) in a population-based cohort identify relevant associated from panel markers. analyzed N = 353 participants cross-sectional sample (KORA FF4) who underwent whole-body magnetic resonance imaging. HIC was assessed by single-voxel spectroscopy with high-speed T2-corrected multi-echo...
Abstract In magnetic resonance imaging (MRI), the perception of substandard image quality may prompt repetition respective acquisition protocol. Subsequently selecting preferred high-quality data from a series acquisitions can be challenging. An automated workflow facilitate and improve this selection. We therefore aimed to investigate applicability an assessment for prediction subjectively acquisition. Our analysis included 11,347 participants with whole-body MRI examinations performed as...
To investigate the association between Aorta (Ao), pulmonary artery (PA) diameters and PA/Ao ratio with right (RV) left ventricle (LV) volumetric properties in subjects free of cardiovascular diseases. In KORA-MRI study, 339 (mean age 56.3 ± 9.1 years; 43.7% female) underwent whole-body 3T-MRI. Ao PA were measured on DIXON sequences. Cvi42 quantified cardiac functional parameters from a SSFP sequence. The relationship ascending (AAo), descending aorta (DAo), as well diameters, RV LV function...
Abstract Background Despite the worldwide burden of diverticular disease, connections between disease and dietary habits remain poorly understood, particularly in an asymptomatic representative sample. We investigated association as assessed by magnetic resonance imaging (MRI) a Western study cohort. Methods Participants from cross-sectional sample population-based cohort underwent whole-body 3T-MRI including isotropic VIBE-Dixon sequence. The presence extent was blinded fashion. Habitual...
Background: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. Methods: 203 study participants underwent MRI tests as part the KORA (Cooperative Health Research Augsburg Region) study. Both visceral tissue (VAT) subcutaneous (SAT) were derived from T1-Dixon sequence, hepatic proton density fat fraction (PDFFhepatic). Associations between spirometric indices such forced vital...
Background: In magnetic resonance imaging (MRI), the comparability of gated and non-gated measurements left atrial (LA) area function their association with cardiovascular risk factors have not been firmly established. Methods: 3-Tesla MRIs were performed on 400 subjects enrolled in KORA (Cooperative Health Research Augsburg Region) MRI study. The LA maximum minimum sizes segmented CINE four-chamber sequences (LAmax LAmin) T1 VIBE-Dixon (NGLA). area-based was defined as LAaf = −...
Zielsetzung Die Untersuchung des Einflusses von Protokollwiederholungen in der Magnetresonanztomographie (MRT) auf die empfundene Bildqualität und Evaluation einer automatisierten Bildqualitätsanalyse zur Vorhersage subjektiv bevorzugten Akquisition.
The best platinum-based chemotherapy regimen remains to be determined in elderly patients treated with definitive chemoradiotherapy for advanced non-small cell lung cancer (NSCLC). Predictive indexes toxicity and survival are also needed give the safest most effective treatment this population.This is a retrospective cohort study. Patients histologically confirmed stage IIIA, IIIB or IIIC NSCLC over 70 years of age, radiotherapy chemotherapy, were included. from two centers between 12/2006...
Zielsetzung To explore the association between MR-based measures of pulmonary function in obstructive and restrictive lung diseases hepatic fat content, visceral (VAT), subcutaneous (SAT) adipose tissue a population-based cohort.
Abstract Background To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. Methods 216 underwent whole-body spirometry as part KORA-FF4 cohort study. Lung semi-automatically using an in-house algorithm. Forced expiratory volume one second (FEV1), forced vital capacity (FVC), residual were measured. Cardiac parameters Cine-SSFP-sequence cvi42, while left...