Chronic subdural hematomas (cSDHs) constitute one of the most prevalent intracranial disease entities requiring surgical treatment. Although mostly taking a benign course, recurrence after treatment is common and associated with additional morbidity costs. Aim this study was to develop hematoma-specific characteristics risk recurrence. All consecutive patients treated for cSDH in single university hospital between 2015 2019 were retrospectively considered inclusion. Size, volume, midline...

Abstract Background To define optimal parameters for the evaluation of vessel visibility in intracranial stents (ICS) and flow diverters (FD) using photon-counting detector computed tomography angiography (PCD-CTA) with spectral reconstructions. Methods We retrospectively analyzed consecutive patients implanted ICS or FD, who received a PCD-CTA between April 2023 March 2024. Polyenergetic, virtual monoenergetic, pure lumen, iodine reconstructions different keV levels (40, 60, 80)...

Phenox flow diverters (p64 and its smaller vessel variant p48) represent an established treatment option for intracranial aneurysms. This study evaluates the safety efficacy of new generation these devices with additional antithrombotic surface coating (HPC). Consecutive patients treated between 2020 2023 at three institutions were retrospectively reviewed aneurysm characteristics, procedural details, complications, angiographic outcomes. Sixty-one (mean age 56 years) 61 The mean size was...

Abstract: BACKGROUND AND AIMS: Cerebral aneurysms are a potentially life-threatening condition for humans. Due to the anatomical variability of different aneurysm types in human patients, animal models indispensable endovascular research. The aim our study was evaluate an model chronical experiments using 12 female Aachen minipigs. MATERIALS METHODS: For creation external carotid and subclavian arteries, Amplatzer vascular plugs were used as occlusion devices, leaving simple stumps that...

Endovascular methods for stroke treatment have become increasingly popular in recent years and continue to be improved. Pigs serve as vivo models endovascular research device testing training purposes. Due a network of small vessels between the cerebral intracranial arteries, called rete mirabile, catheterization brain-supplying arteries pigs is impossible. Alternatively, various porcine can used. Aachen minipigs more last years, but specific data on their vascular diameters are limited...

Abstract Background Cerebral autoregulation (CA) can be impaired in patients with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) . The Pressure Reactivity Index (PRx, correlation of blood pressure and intracranial pressure) Oxygen (ORx, perfusion brain tissue oxygenation, PbtO 2 ) are both believed to estimate CA. We hypothesized that CA could poorer hypoperfused territories during DCI ORx PRx may not equally effective detecting such local variances. Methods...

The branches of the porcine subclavian artery are frequently used in endovascular stroke training and research. This study aimed to determine a weight group, which arterial diameters most closely match human cerebral diameters, thus optimize in-vivo model for neuroendovascular purposes. A group 42 German Landrace swine (45-74 kg) was divided into four subgroups according their weight. Angiographic images were diameter main artery: axillary artery, brachial external thoracic subscapular (at...

Rescue treatment for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage can include induced hypertension (iHTN) and, in refractory cases, endovascular approaches, of which selective, continuous intraarterial nimodipine (IAN) is one variant. The combination iHTN and IAN dramatically increase vasopressor demand. In case unsustainable doses, often prioritized over IAN. However, evidence this regard largely lacking. We investigated the effects a classical (iHTN+IAN) modified (IANonly)...

Chronic subdural hematoma (cSDH) is becoming more prevalent due to population aging and the increasing use of antithrombotic drugs. Postoperative seizure in cSDH have a negative effect on outcome, there currently no consensus regarding prophylactic anti-epileptic drug (AED) treatment. The objective this study was evaluate predisposing triggering factors associated with postoperative epileptic patients cSDH.All patients, who were surgically treated for single tertiary care center between 2015...

(1) Background: Bacterial contamination has been shown to occur during angiographies, although data on its frequency and relevance are sparse. Our aim was evaluate the incidence of bacterial syringes used under sterile conditions neuroangiographies. We sought differentiate between outside inside detect frequency, extent germ spectrum contamination. (2) Methods: prospectively collected 600 samples from 100 Per angiography, fluid three routinely as well themselves were analyzed. analyzed...

The glycoprotein IIb/IIIa antagonist tirofiban has been shown to prevent thromboembolic events during endovascular procedures, but the benefits and risks of its prophylactic early intraprocedural administration for stand-alone coil embolization acutely ruptured aneurysms are still unclear. We conducted a retrospective single-center analysis patients treated aneurysmal subarachnoid hemorrhage with embolization. Two study cohorts were compared according primary antithrombotic medication...

This study investigated supra- and infratentorial structural gray white matter (GM, WM) alterations in patients with degenerative cervical myelopathy (DCM) as an indicator of secondary harm due to chronic cord compression micro trauma. With MRI-based anatomical assessment subsequent voxel-based morphometry analyses, pre- postoperative volume the primary motor cortex (MI), somatosensory (SI), supplementary area (SMA), cerebellum were analyzed 43 DCM 20 controls. We assessed disease-related...

Catheter size, location and circle of Willis anatomy impact the flow conditions during interventional stroke therapy. The aim study was to systematically investigate influence these factors on control in middle cerebral artery by means a computational model based 100 patients with who received endovascular treatment.The dimensions cervical intracranial arteries mechanical thrombectomy for acute ischemic were measured three-dimensional created data. Flow variations catheter configurations...

Knowledge of platelet function in pigs and the effectiveness antiplatelet therapy is important to ensure proper transferability from animal studies humans. Our aim was (1) characterize baseline Aachen minipigs using bedside Multiplate analyzer, (2) compare with Göttingen minipigs, (3) inhibition within first 5 minutes after intravenous administration acetylsalicylic acid (ASA). We characterized hematological parameters 9 minipigs. Historical data 8 unmedicated were used for comparison...

Minipigs are used as in vivo endovascular models, particularly stroke and aneurysm research. However, detailed knowledge of the diameters forelimb arteries that commonly surrogates for human brain–supplying lacking. This study aimed to determine neck Aachen minipigs compare those cerebral order assess validity minipig a intracranial model. We measured external carotid artery eight different branches subclavian 12 using angiographic imaging. Analysed comprised artery, axillary brachial...

Background and Purpose The ThrombX Retriever is a novel mechanical thrombectomy device that adjusts the distance between two mesh segments to axially hold thrombus. A post-market study assessed safety performance in acute ischemic stroke patients with large artery occlusion. Methods single-arm prospective multi-center enrolled at 5 European Centers. Patients had symptomatic large-artery occlusion of intracranial Internal Carotid or Middle Cerebral Artery, M1 segment. primary outcome measure...

<h3>BACKGROUND AND PURPOSE:</h3> Radiographic shunt series are still the imaging technique of choice for radiologic evaluation VP-shunt complications. associated with high radiation exposure and have a low diagnostic performance. Our aim was to investigate performance whole-body ultra-low-dose CT detecting mechanical ventriculoperitoneal <h3>MATERIALS METHODS:</h3> This retrospective study included 186 patients (mean age, 54.8 years) who underwent (100 kV[peak]; reference, 10 mAs). Two...

Background/Objectives: Chronic subdural hematoma (cSDH) is a common disease of growing significance due to the increasing use antithrombotic drugs and population aging. There exists conflicting observational evidence that previous treatment with angiotensin-converting enzyme (ACE) inhibitors reduces rate cSDH recurrence. This study assesses hypothesis ACE may affect recurrence rates by altering membrane formation. Methods: All patients chronic who were operated upon in single university...

ABSTRACT BACKGROUND AND PURPOSE Neuroimaging of intracranial vessels with implanted stents (ICS) and flowdiverters (FD) is limited by artifacts. Photon-Counting-Detector-Computed Tomography (PCD-CT) characterized a higher resolution. The purpose this study was to assess the image quality ultra-high-resolution (UHR) PCD-CT-Angiography (PCD-CTA) spectral reconstructions define best imaging parameters for evaluation vessel visibility in ICS FD. MATERIALS METHODS Retrospective analysis...

Interventional stroke therapy has become standard treatment for patients with acute ischemic strokes. Complete reperfusion (eTICI 3) portrays the best possible technical outcome. The purpose of this study was to determine predictors an unfavorable neurological long-term outcome (mRS 3-6) despite achieving success.

Bacterial contamination of angiographic materials and fluids has been shown to occur during human procedures. Angiographic examinations experiments must be performed under sterile conditions avoid complications due possible subsequent infections. However, data regarding the frequency clinical consequences are limited. Our aim was investigate incidence bacterial experimental angiographies. We tested fluids, syringes endovascular from supply tables for contamination, collecting 252 samples 18...

Background and purpose: During epidemics with an increased prevalence of pulmonary infections, extending stroke CTA examinations acute workup to the whole chest may allow for identification findings that would have been missed on standard examinations. Materials Methods: Our analysis comprised 216 patients suspicion who received extended full-chest cerebrovascular from January 27th 2020 - date first confirmed Covid-19 case in Germany until April 30th 2020. Results: Consolidations...