A5078080640- Advanced X-ray and CT Imaging
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Photoacoustic and Ultrasonic Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aortic aneurysm repair treatments
- Intracranial Aneurysms: Treatment and Complications
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Coronary Artery Anomalies
- Systemic Sclerosis and Related Diseases
- MRI in cancer diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dental Radiography and Imaging
- Acute Ischemic Stroke Management
Hôpital Louis Pradel
2015-2024
Inserm
2014-2024
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2015-2024
Centre National de la Recherche Scientifique
2013-2024
Hôpital de la Croix-Rousse
2015-2024
Université Claude Bernard Lyon 1
2015-2024
Hospices Civils de Lyon
2015-2024
Institut National des Sciences Appliquées de Lyon
2007-2024
Winship Cancer Institute
2023
Laboratoire d’Imagerie Biomédicale
2018-2023
Evolution of intracranial aneurysmal disease is known to be related hemodynamic forces acting on the vessel wall. Low wall shear stress (WSS) has been reported have a negative effect endothelial cells normal physiology and may an important contributor local remodeling arterial aneurysm growth rupture.Seven patient-specific models aneurysms were constructed using MR angiography data acquired at two different time points (mean 16.4+/-7.4 months between points). Numeric simulations flow in...
Background Spatial resolution, soft-tissue contrast, and dose-efficient capabilities of photon-counting CT (PCCT) potentially allow a better quality diagnostic confidence coronary angiography (CCTA) in comparison to conventional CT. Purpose To compare the CCTA scans obtained with clinical prototype PCCT system an energy-integrating detector (EID) dual-layer (DLCT) system. Materials Methods In this prospective board-approved study informed consent, participants artery disease underwent...
In patients with chronic fibrosing interstitial lung disease (ILD), a progressive phenotype (PF-ILD) may develop, but information on the frequency and characteristics of this population outside clinical trials is lacking. We assessed outcomes PF-ILD other than idiopathic pulmonary fibrosis (IPF) in real-world, single-centre cohort. The files all consecutive adult ILD (2010–2017) were examined retrospectively for pre-defined criteria ≥10% high-resolution computed tomography during overlapping...
Abstract Evolution of intracranial aneurysms is known to be related hemodynamic forces such as wall shear stress (WSS) and maximum (MSS). Estimation these parameters can performed using numerical simulations with computational fluid dynamics (CFD), but also directly measured magnetic resonance imaging (MRI) a time‐dependent 3D phase‐contrast sequence encoding each the three components velocity vectors (7D‐MRV). To study accuracy 7D‐MRV in estimating vivo, comparison CFD, patient‐specific CFD...
Thrombus formation in intracranial aneurysms, while sometimes stabilizing lesion growth, can present additional risk of thrombo-embolism. The role hemodynamics the progression aneurysmal disease be elucidated by patient-specific computational modeling. In our previous work, fluid dynamics (CFD) models were constructed from MRI data for three patients who had fusiform basilar aneurysms that thrombus-free and then proceeded to develop intraluminal thrombus. this study, we investigated effect...
Background and Purpose— The purpose of this study was to compare recanalization reperfusion in terms their predictive value for imaging outcomes (follow-up infarct volume, growth, salvaged penumbra) clinical outcome acute ischemic stroke patients. Material Methods— Twenty-two patients admitted within 6 hours onset were retrospectively included study. These underwent a first CT protocol including CT-angiography (CTA) perfusion-CT (PCT) on admission, similar after treatment, typically around...
Purpose To investigate the feasibility of using spectral photon-counting computed tomography (CT) to differentiate between gadolinium-based and nonionic iodine-based contrast material in a colon phantom by characteristic k edge gadolinium. Materials Methods A custom-made was filled with material, gadolinium-filled capsule representing material-enhanced polyp positioned on wall. The scanned preclinical CT system obtain conventional data. By fully multibin information, decomposition performed...
Background Macrophage burden is a major factor in the risk of atherosclerotic plaque rupture, and its evaluation remains challenging with molecular noninvasive imaging approaches. Photon-counting CT (PCCT) k-edge aims to allow for specific detection macrophages using gold nanoparticles. Purpose To perform combination nanoparticles detect quantify macrophage within aortas rabbits. Materials Methods Atherosclerotic control New Zealand white rabbits were imaged before at several time points up...
Computational fluid dynamics (CFD) methods can be used to compute the velocity field in patient-specific vascular geometries for pulsatile physiological flow. Those simulations require geometric and hemodynamic boundary values. The purpose of this study is demonstrate that CFD models constructed from magnetic resonance (MR) angiography velocimetry data predict flow fields are good agreement with vivo measurements therefore provide valuable information clinicians. effect inlet rate conditions...
To evaluate the feasibility of multicolour quantitative imaging with spectral photon-counting computed tomography (SPCCT) different mixed contrast agents.Phantoms containing eleven tubes mixtures varying proportions two agents (i.e. selected from gadolinium, iodine or gold nanoparticles) were prepared so that attenuation each tube was about 280 HU. Scans acquired at 120 kVp and 100 mAs using a five-bin preclinical SPCCT prototype, generating conventional, water, iodine, gadolinium images....
Abstract Diagnostic imaging of hepatocellular carcinoma (HCC) requires a liver CT or MRI multiphase acquisition protocol. Patients would benefit from high-resolution method capable performing multi-phase in single without an increase radiation dose. Spectral Photon-Counting Computed Tomography (SPCCT) has recently emerged as novel and promising modality the field diagnostic radiology. SPCCT is able to distinguish between two contrast agents referred multicolor because, when measuring three...
Over the last decade, dual-energy CT scanners have gone from prototypes to clinically available machines, and spectral photon counting are following. They require a specific reconstruction process, consisting of two steps: material decomposition tomographic reconstruction. Image-based methods perform reconstruction, then decomposition, while projection-based first, As an alternative, 'one-step inversion' been proposed, which simultaneously. Unfortunately, one-step typically slower than their...
Abstract Correct visualization of the vascular lumen is impaired in standard computed tomography (CT) because blooming artifacts, increase apparent size, induced by metallic stents and calcifications. Recently, due to introduction photon-counting detectors X-ray imaging field, a new prototype spectral CT (SPCCT) based on modified clinical system has been tested feasibility study for improving delineation coronary stent architecture. Coronary different metal composition were deployed inside...
The aim of the current study was, first, to assess coronary artery calcium (CAC) scoring potential spectral photon-counting CT (SPCCT) in comparison with computed tomography (CT) for routine clinical protocols. Second, improved CAC detection and quantification at reduced slice thickness were assessed.Raw data was acquired reconstructed several combinations increasing strengths iterative reconstruction (IR) both systems protocols CT. Two CAC-containing cylindrical inserts, consisting...
There is a paucity of data on the epidemiology, survival estimates and healthcare resource utilisation associated costs patients with progressive fibrosing interstitial lung disease (PF-ILD) in France. An algorithm for extracting claims was developed to indirectly identify describe PF-ILD French national administrative database.The database, Système National des Données de Santé (SNDS), includes related ambulatory care, hospitalisations death 98.8% population. In this study, algorithms based...
The purpose of this study was to investigate the feasibility identifying and characterizing three most common types endoleaks within a thoracic aorta aneurysm model using bicolor K-edge imaging with spectral photon-counting computing tomography (SPCCT) system in combination biphasic contrast agent injection.Three (type 1, 2 3) were created dynamic anthropomorphic phantom. Protocol consisted an injection iodinated material followed 80 seconds after gadolinium-based (GBCA). phantom scanned...
To evaluate the quality of virtual monochromatic images (VMIs) from spectral photon-counting CT (SPCCT) and two energy-integrating detector dual-energy (EID-DECT) scanners same manufacturer, for coronary lumen.A 21-cm section Mercury v4.0 phantom was scanned using a cardiac protocol. VMIs 40 to 90 keV were reconstructed high-resolution (HR) parameters EID-DECT SPCCT (CB HRB kernels at 0.67 mm slice thickness, respectively). Ultra-high-resolution (UHR) used in addition (detailed-2 kernel,...
Purpose To estimate the annualized rate of progression vessel-wall volume in carotid arteries 160 patients by using magnetic resonance (MR) imaging and to establish fraction studies that have acceptable image quality. Materials Methods The study procedures consent forms were reviewed approved each site's institutional review board. All U.S. sites conducted all phases this compliance with HIPAA requirements. Written was obtained from participant. One hundred sixty greater than 50% narrowing...