A5029121040- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Cerebrovascular and Carotid Artery Diseases
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Medical Imaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Photoacoustic and Ultrasonic Imaging
- MRI in cancer diagnosis
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Nanoparticle-Based Drug Delivery
- Renal and Vascular Pathologies
- Seismic Imaging and Inversion Techniques
- Central Venous Catheters and Hemodialysis
- Numerical methods in inverse problems
- Cardiovascular Function and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Dental Radiography and Imaging
- Elasticity and Material Modeling
- Acute Ischemic Stroke Management
Université Claude Bernard Lyon 1
2016-2025
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2016-2025
Centre National de la Recherche Scientifique
2014-2024
Inserm
2015-2024
Laboratoire d’Imagerie Biomédicale
2020-2024
Institut National des Sciences Appliquées de Lyon
2014-2024
Hospices Civils de Lyon
2014-2021
Institut National des Sciences Appliquées Rouen Normandie
2021
Hôpital Louis Pradel
2014-2019
Canadian Nautical Research Society
2016-2017
Abstract Purpose: To compare quantitative parameters for assessing the degree of eccentric systolic blood flow in ascending thoracic aorta (AsAo). Materials and Methods: Forty‐one patients were studied with three‐dimensional (3D), cine phase‐contract MRI (4D Flow). Analysis was performed at peak systole a cross‐sectional plane AsAo just distal to sinotubular junction. graded as normal, mildly, or markedly based on qualitative visual assessment. For analysis, jet angle normalized displacement...
A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this not yet demonstrated with such system. We investigated feasibility using to distinguish gold nanoparticles (AuNP) and an iodinated agent. The agents calcium phosphate were imaged in phantoms. Conventional CT, K-edge, iodine...
A new spectral photon-counting CT prototype has the potential for non-invasive quantitative determination of gold nanoparticle biodistribution <italic>in vivo</italic> over time.
Background Macrophage burden is a major factor in the risk of atherosclerotic plaque rupture, and its evaluation remains challenging with molecular noninvasive imaging approaches. Photon-counting CT (PCCT) k-edge aims to allow for specific detection macrophages using gold nanoparticles. Purpose To perform combination nanoparticles detect quantify macrophage within aortas rabbits. Materials Methods Atherosclerotic control New Zealand white rabbits were imaged before at several time points up...
To evaluate the use of a recently developed fast-clearing ultrasmall superparamagnetic iron oxide (USPIO) for detection vascular inflammation in atherosclerotic plaque.The study protocol was approved by animal experimentation ethics committee. A introduced USPIO, P904, and reference-standard ferumoxtran-10, were tested rabbit model induced aortic atherosclerosis. In vivo magnetic resonance (MR) angiography T2*-weighted plaque MR imaging performed at baseline after administration P904...
Purpose To determine the reproducibility of MRI aortic hemodynamic markers and to assess their relationship growth in a cohort patients with bicuspid valves (BAV). Materials Methods Twenty‐five previously studied four‐dimensional (4D) Flow imaging who had at least two separate cross‐sectional studies for were included: tricuspid valve (TAV) controls without valvular disease (n = 12) BAV 13). data from ascending aorta was used calculation peak velocity, normalized flow displacement, maximum...
Objectives In-stent restenosis (ISR) is one of the main long-term complications after coronary stent placement, and ability to evaluate ISR noninvasively using computed tomography (CT) angiography remains challenging. For this application, spectral photon-counting CT (SPCCT) has potential increase image quality reduce artifacts due its advanced detector technology. Our study aimed verify technical clinical a novel SPCCT prototype an phantom setup. Materials Methods Soft plaque-like (45 HU;...
To evaluate the feasibility of multicolour quantitative imaging with spectral photon-counting computed tomography (SPCCT) different mixed contrast agents.Phantoms containing eleven tubes mixtures varying proportions two agents (i.e. selected from gadolinium, iodine or gold nanoparticles) were prepared so that attenuation each tube was about 280 HU. Scans acquired at 120 kVp and 100 mAs using a five-bin preclinical SPCCT prototype, generating conventional, water, iodine, gadolinium images....
Abstract Diagnostic imaging of hepatocellular carcinoma (HCC) requires a liver CT or MRI multiphase acquisition protocol. Patients would benefit from high-resolution method capable performing multi-phase in single without an increase radiation dose. Spectral Photon-Counting Computed Tomography (SPCCT) has recently emerged as novel and promising modality the field diagnostic radiology. SPCCT is able to distinguish between two contrast agents referred multicolor because, when measuring three...
Abstract Correct visualization of the vascular lumen is impaired in standard computed tomography (CT) because blooming artifacts, increase apparent size, induced by metallic stents and calcifications. Recently, due to introduction photon-counting detectors X-ray imaging field, a new prototype spectral CT (SPCCT) based on modified clinical system has been tested feasibility study for improving delineation coronary stent architecture. Coronary different metal composition were deployed inside...
The purpose of this study was to investigate the feasibility identifying and characterizing three most common types endoleaks within a thoracic aorta aneurysm model using bicolor K-edge imaging with spectral photon-counting computing tomography (SPCCT) system in combination biphasic contrast agent injection.Three (type 1, 2 3) were created dynamic anthropomorphic phantom. Protocol consisted an injection iodinated material followed 80 seconds after gadolinium-based (GBCA). phantom scanned...
To evaluate the capabilities of photon counting spectral CT to differentiate components coronary atherosclerotic plaque based on differences in attenuation and iodine-based contrast agent concentration.10 calcified 13 lipid-rich non-calcified histologically demonstrated atheromatous plaques from post-mortem human arteries were scanned with a scanner. Individual photons counted classified one six energy bins 25 70 keV. Based maximum likelihood approach, maps photoelectric absorption (PA),...
Do mathematical symbols evoke spatial representations? Although behavioral studies have long demonstrated interactions between space and the processing of Arabic digits, how to interpret these results remains controversial. Here, we tested whether activity in regions supporting contributes conveying fundamental arithmetic concepts-such as operation signs-even absence associated digits. Using functional magnetic resonance imaging, show that merely perceiving a "+" sign triggers brain support...
The aim of this study is to compare the image quality in vivo coronary stents between an energy integrating detectors dual-layer computed tomography (EID-DLCT) and a clinical prototype spectral photon counting (SPCCT).In January June 2021, consecutive patients with were prospectively enrolled undergo (CT) EID-DLCT (IQon, Philips) SPCCT (Philips). was approved by local ethical committee signed informed consent. A retrospectively electrocardiogram-gated acquisition performed optimized matching...
In the field of cardiovascular imaging, 4D flow MRI provides non-invasive assessment blood flow. Dual velocity encoding (dual-VENC) strategies have emerged to obtain quantitative information on both low and high velocities simultaneously. However, these often encounter difficulties in coping with large ranges. This work presents a dual-VENC sequence that utilizes coprime rule define VENC ratio. A reconstruction algorithm were developed validated vitro at two different strengths, using...
To determine the feasibility of using ferumoxytol-enhanced magnetic resonance (MR) angiography to depict vasculature hemodialysis fistulas and improve image quality compared with nonenhanced time-of-flight (TOF) MR angiography.The study was institutional review board approved in compliance HIPAA regulations. All participants provided written informed consent. TOF first-pass were performed 10 patients upper extremity autogenous fistulas. Ferumoxytol administered as a bolus solution containing...
Altered systolic blood flow in the ascending aorta has been correlated with increased aortic growth patients bicuspid valves (BAVs). We used conventional, 2-dimensional (2D) phase contrast magnetic resonance imaging (PC-MRI) to assess relationship between altered and future BAV.Aortic MRI data were reviewed for 17 adult BAV right-left leaflet fusion undergoing surveillance who had 2D PC-MRI through their aortas on an initial study, follow-up studies more than 1 year later, maximum diameter...
Abstract Computed tomography (CT) is a widely used imaging modality. Among the recent technical improvements to increase range of detection for optimized diagnostic, new devices such as dual energy CT allow elemental discrimination but still remain limited two energies. Spectral photon-counting (SPCCT) an emerging X-ray technology with completely multiple and high spatial resolution (200 μm). This unique technique allows quantification given element thanks element-specific in absorption...