A5005654121- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Atomic and Subatomic Physics Research
- Cardiovascular Disease and Adiposity
- Nanoparticle-Based Drug Delivery
- Acute Ischemic Stroke Management
- Advanced NMR Techniques and Applications
- Coronary Interventions and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Quantum, superfluid, helium dynamics
- Medical Imaging Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- MRI in cancer diagnosis
- Cardiovascular Health and Disease Prevention
- Atherosclerosis and Cardiovascular Diseases
- Advanced Neuroimaging Techniques and Applications
- Hemoglobinopathies and Related Disorders
- Ultrasound and Hyperthermia Applications
- Iron Metabolism and Disorders
- Functional Brain Connectivity Studies
- Nuclear Physics and Applications
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
Laboratoire CarMeN
2014-2025
Université Claude Bernard Lyon 1
2015-2025
Inserm
2014-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2025
Hospices Civils de Lyon
2014-2024
Institut National des Sciences Appliquées de Lyon
2009-2023
Centre National de la Recherche Scientifique
2004-2014
Centre Nantais de Sociologie
2012-2014
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2003-2012
École Normale Supérieure de Lyon
2012
Microglial phagocytosis of apoptotic debris prevents buildup damage neighbor neurons and inflammatory responses. Whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse preclinical monkey models stroke (macaques marmosets) by transient occlusion the medial cerebral artery (tMCAo). By analyzing recently published bulk single cell RNA sequencing databases, show that was not explained transcriptional changes. In contrast, demonstrate...
Although the ability of MRI to investigate carotid plaque composition is well established, mechanism and significance gadolinium (Gd) enhancement remain unknown. We evaluated clinical histological Gd in patients undergoing endarterectomy for stenosis. Sixty-nine scheduled a prospectively underwent 3-T MRI. Carotid was assessed on T1-weighted images performed before 5 minutes after injection. Enhancement recorded according its localization. Histological analysis entire area with matched...
As novel engineered nanoparticles such as carbon nanotubes (CNTs) are extensively used in nanotechnology due to their superior properties, it becomes critical fully understand biodistribution and effect when accidently inhaled. A noninvasive follow-up study would be beneficial evaluate the of nanotube deposition after exposure directly vivo. Combined helium-3 proton magnetic resonance (MRI) were a rat model biological impact raw single-wall CNTs (raw-SWCNTs) superpurified SWCNTs (SP-SWCNTs)....
To evaluate the use of a recently developed fast-clearing ultrasmall superparamagnetic iron oxide (USPIO) for detection vascular inflammation in atherosclerotic plaque.The study protocol was approved by animal experimentation ethics committee. A introduced USPIO, P904, and reference-standard ferumoxtran-10, were tested rabbit model induced aortic atherosclerosis. In vivo magnetic resonance (MR) angiography T2*-weighted plaque MR imaging performed at baseline after administration P904...
Background: Single-walled carbon nanotubes (SWCNT) hold promise for applications as contrast agents and target delivery carriers in the field of nanomedicine. When administered vivo, their biodistribution pharmacological profile needs to be fully characterized. The tissue distribution potential impact on metabolism depend shape, coating, metallic impurities. Because standard radiolabeled or fluorescently-labeled pharmaceuticals are not well suited long-term vivo follow-up nanotubes,...
Abstract Context The effects of energy-balanced bed rest on metabolic flexibility have not been thoroughly examined. Objective We investigated the 21 days rest, with and without whey protein supplementation, while maintaining energy balance. hypothesized that supplementation mitigates inflexibility by preventing muscle atrophy. Design Setting Randomized crossover longitudinal study conducted at German Aerospace Center, Cologne, Germany. Participants Interventions Ten healthy men were...
The choroid plexuses (ChPs) perform indispensable functions for the development, maintenance and functioning of brain. Although they have gained considerable interest in last years, their involvement brain disorders is still largely unknown, notably because deep location inside hampers non-invasive investigations. In-vivo iImaging tools become instrumental to diagnosis pathophysiological study neurological neuropsychiatric diseases. This review summarizes knowledge that has been gathered...
Microvascular dysfunction and no-reflow are considered a major cause of secondary damage despite revascularization in acute ischemic stroke (AIS), ultimately affecting patient outcomes. We used quantitative PET-MRI imaging to characterize early microvascular damages preclinical non-human primate model mimicking endovascular mechanical thrombectomy (EVT). During occlusion, PET perfusion MRI diffusion were measure lesion core volumes respectively. Following revascularization, multiparametric...
The method concerning in vivo proton HR-MAS NMR metabolic profiling of the freshwater cladoceran Daphnia magna is presented. Viability tests D. under different spinning rates were performed. All surviving daphnids after analysis have developed eggs and embryos like control animals. Better survival rate at slowest rotation speed observed. maximum length during which integrity daphnid maintained was assessed. recorded spectra daphnia attributed to lipids from triglycerol category. Saturated...
The aim of this study was to analyze the effects exercise training on oxidative stress in sickle cell trait carriers. Plasma levels [advanced oxidation protein products (AOPP), carbonyl, malondialdehyde (MDA), and nitrotyrosine], antioxidant markers [catalase, glutathione peroxidase (GPX), superoxide dismutase (SOD)], nitrite nitrate (NOx) were assessed at baseline, immediately following a maximal test (T(ex)), during recovery (T(1h), T(2h), T(24h)) trained (T: 8 h/wk minimum) untrained (U:...
Abstract In this article, we report the safety evaluation of gadolinium-based nanoparticles in nonhuman primates (NHP) context magnetic resonance imaging (MRI) studies atherosclerosis bearing animals and healthy controls. NHP, pharmacokinetics toxicity profiles demonstrated absence dose, time, sex-effects, as well a suitable tolerance intravenous administration nanoparticles. We investigated their properties for arterial plaque standard diet or high cholesterol compared characteristics with...
Inflammation within atherosclerotic lesions increases the risk for plaque rupture and thrombosis. A functional approach to analysis is intravenous administration of ultrasmall superparamagnetic particles iron oxide (USPIO) that enables visualization macrophages residing in plaques. In this study, we sought characterize age-related inflammatory status associated with atherosclerosis lesion progression ApoE mice using USPIO-enhanced magnetic resonance imaging (MRI).A total 24 were divided 4...
Objectives The aim of this study was to assess and delineate chronic myocardial infarction (CMI) using precontrast postcontrast T1 mapping techniques including quantification extracellular volume fractions (ECVs). Materials Methods A total 26 patients with CMI were examined at 1.5 T applying a modified Look-Locker Inversion Recovery sequence before 10 minutes after contrast 3 short-axis slice positions. An inversion recovery gradient recalled echo (standard reference) used for imaging late...
Atherosclerotic plaque development in the arterial wall is result of complex interaction between wall's endothelial layer and blood hemodynamics. However, hemodynamic parameters inflammation evolution not yet fully understood. The aim present study was to investigate relation shear stress (WSS) vessel during atherosclerotic a minipig model carotid stenosis.A surgical procedure performed create left common artery stenosis by placement perivascular cuff minipigs under atherogenic diet. Animals...
Pollutants are suspected to contribute the etiology of obesity and related metabolic disorders. Apart from occupational exposure which concerns a subset chemicals, humans mostly exposed large variety all life-long at low doses. Food ingestion is major route it suggested that pollutants have worsened impact when combined with high-fat diet. In experimental studies described herein, we aimed add further evidence on food using recently set up model in mice fed high-fat/high-sucrose diet (HFSD)...
Abstract Choroid plexus (ChPs) are involved in the early inflammatory response that occurs many brain disorders. However, activation of immune cells within ChPs to neuroinflammation is still largely unexplored in-vivo . There therefore a crucial need for developing imaging tool would allow non-invasive monitoring ChP involvement these diseases. Magnetic resonance (MRI) coupled with superparamagnetic particles iron oxide (SPIO) minimally invasive technique allowing track phagocytic Our aim...
Stroke is a devastating disease. Endovascular mechanical thrombectomy dramatically changing the management of acute ischemic stroke, raising new challenges regarding brain outcome and opening up avenues for protection. In this context, relevant experiment models are required testing therapies addressing important questions about infarct progression despite successful recanalization, reversibility lesions, blood-brain barrier disruption reperfusion damage. Here, we developed minimally...