A5035921217- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Radiopharmaceutical Chemistry and Applications
- Olfactory and Sensory Function Studies
- Assembly Line Balancing Optimization
- Tryptophan and brain disorders
- Advanced Manufacturing and Logistics Optimization
- Alzheimer's disease research and treatments
- Scheduling and Optimization Algorithms
- Medical Image Segmentation Techniques
- Advanced Chemical Sensor Technologies
- Pickering emulsions and particle stabilization
- Luminescence and Fluorescent Materials
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Nanoparticle-Based Drug Delivery
- Multiple Sclerosis Research Studies
- Diet and metabolism studies
Centre d'Exploration et de Recherche Médicale par Emission de Positons
2015-2024
Université Claude Bernard Lyon 1
2023
Centre Hospitalier Le Vinatier
2023
Centre de Recherche en Neurosciences de Lyon
2023
Imagerie par Résonance Magnétique Médicale et Multi-Modalités
2012-2021
Hospices Civils de Lyon
2018
Accumulation of α-synuclein (α-syn) is a neuropathological hallmark synucleinopathies. To date, no selective α-syn positron emission tomography (PET) radiotracer has been identified. Our objective was to develop the first original, selective, and specific PET radiotracer. Chemical design inspired from three structural families that demonstrated interesting binding characteristics used as starting point. Bioinformatics modeling fibrils then employed select best molecular candidates before...
Introduction Preclinical in vivo imaging requires precise and reproducible delineation of brain structures. Manual segmentation is time consuming operator dependent. Automated as usually performed via single atlas registration fails to account for anatomo-physiological variability. We present, evaluate, make available a multi-atlas approach automatically segmenting rat MRI extracting PET activies. Methods High-resolution 7T 2DT2 MR images 12 Sprague-Dawley brains were manually segmented into...
We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent static [18F]FDG PET/CT MRI, resulting in PET, T1 MPRAGE FLAIR CT images. Two were excluded after visual quality control. describe the acquisition parameters, image processing pipeline provide participants' individual demographics (mean age 38 ± 11.5 years, range 23-65, 20 women). Volumetric analysis MRIs showed results line with literature. A...
Efficiency of drug administration is related to the inhibition adverse effects, and can be improved by targeting through lipid nanocarriers encapsulation. Targeting technology generally goes along with nanocarrier functionalization that surface modification and/or ligand grafting. The great advantage nanoemulsions their loading capability possibilities encapsulate several entities in a single droplet, however, decoration droplets strongly anchored reactive functions challenging. This study...
Inflammation may play a role in the development of epilepsy after brain insults. [ 11 C]-( R)-PK11195 binds to TSPO, expressed by activated microglia. We quantified binding during epileptogenesis pilocarpine-induced status epilepticus (SE), model temporal lobe epilepsy. Nine male rats were studied thrice (D0-1, D0 + 6, 35, = SE induction). In same session, 7T T2-weighted images and DTI for mean diffusivity (MD) fractional anisotropy (FA) maps acquired, followed dynamic PET/CT. On femoral...
Abstract Using different tracers in positron emission tomography (PET) imaging can bring complementary information on tumor heterogeneities. Ideally, PET images of should be acquired simultaneously to avoid the bias induced by movement and physiological changes between sequential acquisitions. Previous studies have demonstrated feasibility recovering separated signals or parameters two more injected (quasi-)simultaneously a single acquisition. In this study, generic framework context...
Serotonin 5-HT1A receptors constitute an attractive therapeutic target for various psychiatric or neurodegenerative disorders. These are expressed in multiple brain regions on different neuronal populations and can be coupled with distinct G-protein subtypes; such functional diversity complicates the use of ligands several pathologies where it would desirable to stimulate a precise region. Therefore, using "biased agonists" able specifically certain subpopulations enable achievement better...
The leading treatment for motor signs of Parkinson's disease is L-DOPA, but, upon extended use, it can lead to levodopa-induced dyskinesia (LID). Serotonergic neurons are involved in LID etiology and previous pre-clinical studies have shown that NLX-112, a 5-HT1A biased agonist, has robust antidyskinetic effects. Here, we investigated its effects hemiparkinsonian (HPK) rats with unilateral nigrostriatal 6-OHDA lesion.We compared HPK (i.e., sensitized the dyskinetic chronic L-DOPA) without...
Alpha-synuclein (α-syn) aggregation is a neuropathological hallmark of many neurodegenerative diseases, collectively termed synucleinopathies. There currently no pre-mortem diagnosis tool for these diseases. Although some compounds have been described as potential ligands α-syn aggregates, specific PET radiotracer aggregated available. Recently, [18F]BF227 has proposed an in the absence other candidates. We here, first time, to use this accelerated mouse model synucleinopathy presenting...
Serotonin is involved in a variety of physiological functions and brain disorders. In this context, efforts have been made to investigate the vivo fluctuations neurotransmitter using positron emission tomography (PET) imaging paradigms. Since serotonin full agonist, it binds preferentially G-protein coupled receptors. contrast, antagonist PET ligands additionally interact with uncoupled This could explain lack sensitivity current 5-HT1A radiopharmaceuticals which are mainly antagonists...
The observation that amyloid radiotracers developed for Alzheimer’s disease bind to cerebral white matter paved the road nuclear imaging of myelin in multiple sclerosis. lysolecithin (lysophosphatidylcholine (LPC)) rat model demyelination proved useful evaluating and comparing candidate target myelin. Focal following stereotaxic LPC injection is larger than lesions observed experimental autoimmune encephalitis models followed by spontaneous progressive remyelination. Moreover, contralateral...
Memory consolidation involves reorganization at both the synaptic and system levels. The latter gradual of brain regions that support memory has been mostly highlighted using hippocampal-dependent tasks. standard model posits hippocampus becomes gradually less important over time in favor neocortical regions. In contrast, this circuits amygdala-dependent tasks investigated. Moreover, question addressed primarily lesion or cellular imaging approaches thus precluding comparison recent remote...
In PET imaging, research groups have recently proposed different experimental set ups allowing multiple animals to be simultaneously imaged in a scanner order reduce the costs and increase throughput. those studies, technical feasibility was demonstrated signal degradation caused by additional mice FOV characterized, however, impact of on outcome study has not yet been studied. Here we thoroughly investigated, using Monte Carlo simulated [18F]FDG [11C]Raclopride designs for whole-body brain...
Summary Aims Alpha‐synuclein (α‐syn) aggregation is a neuropathological hallmark of neurodegenerative synucleinopathies. This in vivo study explored glucose metabolism and dopaminergic serotoninergic neurotransmission KO α‐syn, wild‐type mice an accelerated murine model synucleinopathy (M83). Methods Micro PET acquisitions were performed all animals aged 5‐6 months using five radiotracers exploring brain ([ 18 F] FDG ), dopamine 11 C]raclopride, [ C] PE 2I) serotonin MPPF , DASB ). For...
The gold-standard treatment for Parkinson's disease is L-DOPA, which in the long term often leads to levodopa-induced dyskinesia. Serotonergic neurons are partially responsible this, by converting L-DOPA into dopamine leading its uncontrolled release as a "false neurotransmitter". stimulation of 5-HT1A receptors can reduce involuntary movements but this mechanism poorly understood.This study aimed investigate functionality using positron emission tomography hemiparkinsonian rats with or...
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Abstract Background Estimates suggest that approximatively 25% of the world population will be overweight in 2025. Better understanding pathophysiology obesity help to develop future therapeutics. Serotonin subtype 6 receptors (5-HT ) have been shown critically involved appetite reduction and weight loss. However, it is not known if pathological cascade triggered by modifies density 5-HT brain. Methods Influence diet-induced (DIO) Wistar rats was explored using MRI (whole-body fat) PET ([ 18...
Ketamine, a glutamate NMDA receptor antagonist, is suggested to act very rapidly and durably on the depressive symptoms including treatment-resistant patients but its mechanisms of action remain unclear. There requirement for non-invasive biomarkers, such as imaging techniques, which hold promise in monitoring elucidating therapeutic impact.We explored glucose metabolism with [18F]FDG positron emission tomography (PET) ten male rats longitudinal study designed compare patterns immediately...
Abstract We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent [ 18 F]FDG PET/CT MRI, resulting in PET, T1 MPRAGE FLAIR CT images. Two were excluded after visual quality control. describe the acquisition parameters, image processing pipeline provide participants’ individual demographics (mean age 38 ± 11.5 years, range 23-65, 20 women). Volumetric analysis MRIs showed results line with...