A5086411832- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Treatment of Major Depression
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Tuberous Sclerosis Complex Research
- Radiopharmaceutical Chemistry and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Polyomavirus and related diseases
- Genetic and Kidney Cyst Diseases
- Radiation Detection and Scintillator Technologies
- Nicotinic Acetylcholine Receptors Study
- MRI in cancer diagnosis
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Nuclear reactor physics and engineering
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Nuclear Physics and Applications
Inserm
2008-2024
Centre National de la Recherche Scientifique
2012-2024
Université Claude Bernard Lyon 1
2010-2024
Centre d'Exploration et de Recherche Médicale par Emission de Positons
1999-2024
Hospices Civils de Lyon
2014-2024
Centre de Recherche en Neurosciences de Lyon
2005-2023
Centre Hospitalier Le Vinatier
2014-2020
Fondation Neurodis
2014
Hospital Clínic de Barcelona
2014
Imagerie par Résonance Magnétique Médicale et Multi-Modalités
2012-2013
Environmental enrichment of laboratory animals influences brain plasticity, stimulates neurogenesis, increases neurotrophic factor expression, and protects against the effects insult. However, these positive are not constantly observed, probably because standardized procedures environmental lacking. Therefore, we engineered an enriched cage (the Marlau™ cage), which offers: (1) minimally stressful social interactions; (2) increased voluntary exercise; (3) multiple entertaining activities;...
We have undertaken a test-re-test [11C]flumazenil (FMZ) PET study in 10 drug-resistant epileptic patients, including six with mesiotemporal epilepsy (MTE), and normal controls, order to investigate seizure-related short-term plasticity of benzodiazepine (BZD) receptors. All subjects underwent two FMZ-PET scans at 1 week interval. Patients benefited from concurrent video-EEG monitoring which allowed determination the duration interictal period (IP) preceding each PET. Test-re-test whole brain...
Summary Objective Interictal [18F]fluorodeoxyglucose–positron emission tomography ( FDG ‐ PET ) is used in the presurgical evaluation of patients with drug‐resistant focal epilepsy. We aimed at clarifying its relationships ictal high‐frequency oscillations iHFO s) shown to be a relevant marker seizure‐onset zone. Methods studied correlation between and epileptogenicity maps an unselected series 37 successive having been explored stereo‐electroencephalography (SEEG). Results At group level,...
We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent static [18F]FDG PET/CT MRI, resulting in PET, T1 MPRAGE FLAIR CT images. Two were excluded after visual quality control. describe the acquisition parameters, image processing pipeline provide participants' individual demographics (mean age 38 ± 11.5 years, range 23-65, 20 women). Volumetric analysis MRIs showed results line with literature. A...
Tuberous sclerosis complex (TSC) is often associated with cerebral tubers and medically intractable epilepsy. We reevaluated whether increased uptake of α-[(11) C]methyl-l-tryptophan (AMT) in tuber epileptogenicity.We included 12 patients (six male, 4-53 years old) TSC refractory seizures who were evaluated for epilepsy surgery our center, including video-electroencephalographic (EEG) monitoring, fluid-attenuated inversion recovery magnetic resonance imaging (FLAIR MRI), positron emission...
(18)F-4-(2'-methoxyphenyl)-1-[2'-(N-2-pyridinyl)-p-fluorobenzamido]-ethyl-piperazine ((18)F-MPPF) PET has proved to be a sensitive technique in the presurgical evaluation of patients with drug-resistant temporal lobe epilepsy (TLE), but significant proportion visually detected abnormalities failed by standard statistical parametric mapping (SPM) analysis. This study aimed at describing voxel-based method for computing interhemispheric asymmetric index (AI) using software and applying...
Inflammation may play a role in the development of epilepsy after brain insults. [ 11 C]-( R)-PK11195 binds to TSPO, expressed by activated microglia. We quantified binding during epileptogenesis pilocarpine-induced status epilepticus (SE), model temporal lobe epilepsy. Nine male rats were studied thrice (D0-1, D0 + 6, 35, = SE induction). In same session, 7T T2-weighted images and DTI for mean diffusivity (MD) fractional anisotropy (FA) maps acquired, followed dynamic PET/CT. On femoral...
To investigate the impact of various antipsychotic drugs on 5-HT1A serotoninergic system, we performed a [F]4-(2-methoxyphenyl)-1-[2-(N-2-pirydynyl)-p-luorobenzamido]-ethyl-piperazine PET study in 19 schizophrenic patients treated with either aripiprazole, which has partial agonist activity at receptors, or second-generation antipsychotics (SGA) (olanzapine risperidone), do not demonstrate such property. We used simplified reference tissue model to generate parametric images [F]MPPF-binding...
Dysembryoplastic neuroepithelial tumors (DNTs) represent a prevalent cause of epileptogenic brain tumors, the natural evolution which is much more benign than that most gliomas. Previous studies have suggested [(11)C]methionine positron emission tomography (MET-PET) could help to distinguish DNTs from other and hence optimize management patients. Here, we reassessed diagnostic accuracy MET-PET for differentiation between DNT neoplasms in larger population.We conducted retrospective study 77...
Abstract Objective Normal interictal [ 18 F]FDG‐PET can be predicted from the corresponding T1w MRI with Generative Adversarial Networks (GANs). A technique we call SIPCOM (Subtraction Interictal PET Co‐registered to MRI) then used compare epilepsy patients' and clinical PET. We assessed ability of identify Resection Zone (RZ) in patients drug‐resistant (DRE) reference visual statistical parametric mapping (SPM) analysis. Methods Patients complete presurgical work‐up subsequent SEEG...
We have observed a falsely lateralizing mesial temporal [11C]-flumazenil binding asymmetry in three patients who had lobe epilepsy (TLE) with normal hippocampal volumes. This abnormality was not detected 3 months later two of the underwent second PET study. conclude that transient and changes flumazenil might occur TLE no sclerosis.
Whether the intrinsic epileptogenicity of hypothalamic hamartomas (HH) is responsible for entire clinical spectrum epileptic, neuropsychological and behavioural disorders associated with HH, remains an open issue, in as much morphologically similar HH can be dramatically different seizure types cognitive outcomes. The aim this study was to investigate brain glucose metabolism patients epileptogenic attempt identify signs focal cortical subcortical dysfunction which might correlate other...
A third of patients with intractable temporal lobe epilepsy and hippocampal sclerosis (HS) are not seizure free (NSF) after surgery. Increased periventricular [11C]flumazenil (FMZ) binding, reflecting heterotopic neuron concentration, has been described as one predictor NSF outcome at the group level. We aimed to replicate this finding in an independent larger cohort investigated whether can be predicted individuals. Preoperative [11C]FMZ summed radioactivity images were available for 16 HS...
Previous Positron Emission Tomography (PET) studies of 5-HT1A receptors have shown an influence several genetic factors, including the triallelic serotonin transporter gene-linked polymorphic region on binding potential (BPND) these receptors. The aim our study was to investigate relationship between a promoter polymorphism and another selective receptor antagonist, [18F]MPPF, in healthy subjects. Thirty-five volunteers, 23 women, underwent [18F]MPPF scan were genotyped for both C(-1019)G...
Ketamine, a glutamate NMDA receptor antagonist, is suggested to act very rapidly and durably on the depressive symptoms including treatment-resistant patients but its mechanisms of action remain unclear. There requirement for non-invasive biomarkers, such as imaging techniques, which hold promise in monitoring elucidating therapeutic impact.We explored glucose metabolism with [18F]FDG positron emission tomography (PET) ten male rats longitudinal study designed compare patterns immediately...
Abstract We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent [ 18 F]FDG PET/CT MRI, resulting in PET, T1 MPRAGE FLAIR CT images. Two were excluded after visual quality control. describe the acquisition parameters, image processing pipeline provide participants’ individual demographics (mean age 38 ± 11.5 years, range 23-65, 20 women). Volumetric analysis MRIs showed results line with...