A5109515720- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Analytical Chemistry and Sensors
- Neuroscience and Neuropharmacology Research
- Lanthanide and Transition Metal Complexes
- Neuroscience and Neural Engineering
- Bone Tumor Diagnosis and Treatments
- Nuclear Physics and Applications
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- CCD and CMOS Imaging Sensors
- Particle Detector Development and Performance
- Optical Imaging and Spectroscopy Techniques
- Chemical Reactions and Isotopes
- Oral and Maxillofacial Pathology
- Photoacoustic and Ultrasonic Imaging
- Neutrino Physics Research
- Advanced X-ray and CT Imaging
- Estrogen and related hormone effects
- Advanced Optical Sensing Technologies
- Meningioma and schwannoma management
- Radiopharmaceutical Chemistry and Applications
Université Paris Cité
1999-2024
Centre National de la Recherche Scientifique
1994-2024
Université Paris-Saclay
2000-2024
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
2023-2024
Institut National de Physique Nucléaire et de Physique des Particules
2006-2024
Université Paris-Sud
1994-2020
Délégation Paris 7
2014
Institut d'Imagerie Biomédicale
2008-2011
Institut de Physique
1992-2006
Université Paris Dauphine-PSL
2005
Although high-resolution tomographs provide a new approach that strongly simplifies the measurement of in vivo tracer biodistribution and kinetics small animals, they suffer from an important drawback: need for animal anesthesia or immobilization, which restricts neurophysiological investigations. Furthermore, quantitative experiments realized on brain sometimes only require simple radioactivity achieved few local points do not necessarily imply use tomograph, is detector high cost. These...
The development of a hand-held /spl gamma/ imaging probe for inside body localization small tumors is first interest radio-guided operative cancer surgery. In that context, we have developed sub-millimeter spatial resolution, field view, per-operative compact imager (POCI). It consists head module composed high resolution tungsten collimator and YAP:Ce crystal plate, optically coupled to an intensified position sensitive diode (HSD). We report here the essential performance characteristics...
The principle of a new tomograph (TOHR) dedicated for small volume analysis with very high resolution is presented. authors use uncorrelated multi-photon (X- or gamma rays) radioisotopes and large solid angle focusing collimator to produce tomographic images without reconstruction algorithm. With this device, detection efficiency are independent submillimeter can be achieved. A feasibility study shows that collimators made stack chemically etched plates achieve the predicted performances...
Several high-resolution tomographs dedicated to small animal imaging are presently under development. However, these devices limited by two major drawbacks: their cost is high and they require anaesthesia immobilization, thus restricting the scope of investigations. Therefore, we have developed SIC (French acronym for "Sonde IntraCerebrale") a low-cost beta microprobe measuring local radioactivity in awake, freely moving animals. Besides good sensitivity, offers advantage temporal...
In this paper, the authors validated microPET FOCUS modelling with GATE. The performances of Monte Carlo platform were presented on voxelized rat brain phantom, specially for simulation realistic [C-11]Raclopride exam a injected dose and acquisition time. These results are consequence complete installation cluster computing architecture. Finally, showed first preliminary approach to improve quantitative analysis in dopaminergic studies an implementation corrections about positron range gamma...
The growing interest of cancer surgeons in intra-operative probes has led to the development several prototypes high resolution mini gamma cameras. aim this paper is present a global characterization one that we developed and corresponding first evaluation clinical context. current prototype POCI (per-operative compact imager) 24 mm diameter intensified position sensitive diode optically coupled scintillation crystal plate novel parallel hole tungsten collimator. In order face various...
The β-microprobe is a simple and versatile technique complementary to small animal positron emission tomography (PET).It relies on local measurements of the concentration positron-labeled molecules.So far, it has been successfully used in anesthetized rats for pharmacokinetics experiments study brain energetic metabolism.However, ability provide accurate quantitative using 18 F, 11 C 15 O tracers likely suffer from contribution 511 keV gamma rays background signal positrons loci surrounding...
The investigation of neurophysiological mechanisms underlying the functional specificity brain regions requires development technologies that are well adjusted to in vivo studies small animals. An exciting challenge remains combination imaging and behavioural studies, which associates molecular processes neuronal communications their related actions. A pixelated intracerebral probe (PIXSIC) presents a novel strategy using submillimetric for beta(+) radiotracer detection based on silicon...
The formation of the Earth remains an epoch with mysterious puzzles extending to our still incomplete understanding planet's potential origin and bulk composition. Direct confirmation Earth's internal heat engine was accomplished by successful observation geoneutrinos originating from uranium (U) thorium (Th) progenies, manifestations natural radioactivity dominated potassium (40K) decay chains (238U) (232Th). This radiogenic energy output is critical planetary dynamics must be accurately...
We present a design study of PIXSIC, new β <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> radiosensitive microprobe implantable in rodent brain dedicated to vivo and autonomous measurements local time activity curves beta radiotracers small (a few mm xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) volume tissue. This project follows the initial previously developed at IMNC, which has been validated several neurobiological...
New radioimagers, the HRRI (high resolution radioimager) and Phosphorimager (phosphor screen: PS), apt to display more ample linear dose-response scale than radio-sensitive films, were tested in comparaison with quantitative autoradiography (QA). GnRH receptor saturation experiments achieved on tissue sections (rat pituitary, rat brain, human ovary) a iodinate agonist (125l-[D-Ala6, Des-Gly10]-LH-RH Ethylamide) for determination of affinity constant (Kd). In comparable results obtained 3...
Preclinical behavior neuroimaging gathers simultaneous assessment of and functional brain imaging. It is a potential key breakthrough to improve the understanding processes assess validity preclinical studies in drug development. Achieving such combination difficult, anesthesia or restraints inherent conventional nuclear imaging preclude its use for studies. In that context, we have proposed an original strategy using submillimetric probes directly measures positrons inside rat brain. This...
The authors have developed a multi-functional portable /spl gamma/-radio-imager (RITM) based on position sensitive photo-multiplier tube (PSPMT) in order to evaluate the potential of such mini gamma/-camera concept radio-pharmacology and nuclear medicine. report here an evaluation their RITM device for bone surgery. It concerns localization Osteoid Osteoma (benign tumor) performed theater block before skin incision during surgical lesion extraction. In over 13 cases studied, diagnosis...