A5026467248- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Peptidase Inhibition and Analysis
- Viral Infectious Diseases and Gene Expression in Insects
- Quinazolinone synthesis and applications
- CAR-T cell therapy research
- Biosimilars and Bioanalytical Methods
- RNA Interference and Gene Delivery
- Genetic Neurodegenerative Diseases
- Genetic factors in colorectal cancer
- Lymphatic System and Diseases
- CRISPR and Genetic Engineering
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Neonatal Respiratory Health Research
- Cancer Risks and Factors
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Mycotoxins in Agriculture and Food
- Colorectal Cancer Treatments and Studies
- Biomarkers in Disease Mechanisms
- Neuroscience and Neuropharmacology Research
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2024
MRC Human Immunology Unit
2023
MRC Weatherall Institute of Molecular Medicine
2023
University of Oxford
2023
Centre d'Exploration et de Recherche Médicale par Emission de Positons
2002
Blood and lymphatic vessels form a versatile transport network provide inductive signals to regulate tissue-specific functions. in bone osteogenesis hematopoiesis, but current dogma suggests that lacks vessels. Here, by combining high-resolution light-sheet imaging cell-specific mouse genetics, we demonstrate presence of human bones. We find expand during genotoxic stress. VEGF-C/VEGFR-3 signaling stress-induced IL6 drive lymphangiogenesis During lymphangiogenesis, secretion CXCL12 from...
Abstract Purpose: TIGIT blockade in our ex vivo model of bone marrow (BM) reduced the number malignant plasma cells (PC) only half patients with multiple myeloma. Here, we wanted to investigate whether increased expression ligands may inhibit T-cell immune response promoting resistance blockade. Experimental Design: We first characterized and phenotype BM macrophages different stages disease by multiparameter flow cytometry. assessed effect on PC survival performing experiments analyzed...
<div>AbstractPurpose:<p>TIGIT blockade in our <i>ex vivo</i> model of bone marrow (BM) reduced the number malignant plasma cells (PC) only half patients with multiple myeloma. Here, we wanted to investigate whether increased expression TIGIT ligands may inhibit T-cell immune response promoting resistance blockade.</p>Experimental Design:<p>We first characterized and phenotype BM macrophages different stages disease by multiparameter flow cytometry. We...
<p>Supplementary Figure S1: Gating strategy</p>
<p>Supplementary Figure S2: Expression of TIGIT axis on CD14+ and PCs</p>
<p>Supplementary Figure S3: Transcriptomic analysis CD8 T cells on PVR or nectin2</p>
<p>Supplementary Figure S3: Transcriptomic analysis CD8 T cells on PVR or nectin2</p>
<div>AbstractPurpose:<p>TIGIT blockade in our <i>ex vivo</i> model of bone marrow (BM) reduced the number malignant plasma cells (PC) only half patients with multiple myeloma. Here, we wanted to investigate whether increased expression TIGIT ligands may inhibit T-cell immune response promoting resistance blockade.</p>Experimental Design:<p>We first characterized and phenotype BM macrophages different stages disease by multiparameter flow cytometry. We...
<p>Supplementary Figure S1: Gating strategy</p>
<p>Supplementary Figure S2: Expression of TIGIT axis on CD14+ and PCs</p>
Chimeric antigen receptor-T (CAR-T) cells directed against B-cell maturation (BCMA) are an effective treatment for multiple myeloma (MM), but short persistence and frequent relapses challenges this immunotherapy. This lack of durability has been attributed to the premature terminal differentiation CAR-T which prevents formation long-lived memory that maintain anti-tumour responses. To improve long-term efficacy, we used CRISPR/Cas9-mediated gene editing ablate expression transcription factor...