A5038221893- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Neurogenesis and neuroplasticity mechanisms
- Fatty Acid Research and Health
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
Achucarro Basque Center for Neuroscience
2014-2023
University of the Basque Country
2014-2023
Ikerbasque
2017-2020
Euskadiko Parke Teknologikoa
2014-2016
During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal but has an active role in maintaining neurogenesis. First, found neurogenesis was disrupted male female mice chronically deficient for two pathways: purinergic receptor P2Y12, tyrosine kinases TAM family Mer kinase (MerTK)/Axl. In contrast,...
Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory and autoimmune diseases, but its role the diseased brain poorly explored. Recent findings suggest that adult hippocampal neurogenic niche, where excess newborn cells undergo apoptosis physiological conditions, phagocytosis efficiently executed by surveillant, ramified microglia. To test whether microglia are efficient phagocytes as well, we confronted them with series apoptotic challenges discovered...
Microglial phagocytosis of apoptotic debris prevents buildup damage neighbor neurons and inflammatory responses. Whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse preclinical monkey models stroke (macaques marmosets) by transient occlusion the medial cerebral artery (tMCAo). By analyzing recently published bulk single cell RNA sequencing databases, show that was not explained transcriptional changes. In contrast, demonstrate...
Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of brain. Westernization dietary habits in both developed and developing countries is accompanied by a progressive reduction intake n-3 PUFAs. Low maternal PUFAs has been linked to neurodevelopmental diseases Humans. However, deficiency-mediated mechanisms affecting development central nervous system poorly understood. Active microglial engulfment synapses regulates brain development. Impaired synaptic pruning...
Adult hippocampal neuroprogenitors give rise to both neurons and astrocytes. As are lost with increased age, neurogenesis concomitantly decreases. However, the dynamics of neuron astrocyte generation throughout adulthood has not been systematically examined. Here, we analyzed niche longitudinally (from 2 h 30d cell life) transversally 1 m 12 age) generated a Marsaglia polar random simulation model predict newborn dynamics. The sharp decrease in production was largely predicted by number...
Abstract Apoptosis is a ubiquitous process occurring in the brain under both physiological and pathological conditions. The central nervous system (CNS) requires an active efficient clean‐up to prevent spillover of intracellular contents into surrounding parenchyma suppress initiation inflammatory immune responses. Microglia, resident professional phagocytes brain, are cells charge removal these dead by named phagocytosis. Therefore, microglial phagocytosis vital mechanism maintain tissue...
SUMMARY During adult hippocampal neurogenesis, the majority of newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent spillover their intracellular contents. Here, we propose that phagocytosis is not merely a passive process corpse removal but has an active role in maintaining neurogenesis. First, found neurogenesis was disrupted mice chronically deficient for two microglial pathways (P2Y12 MerTK/Axl), transiently increased which MerTK expression...
SUMMARY Omega-3 fatty acids (n-3 polyunsaturated acids; n-3 PUFAs) are essential for the functional maturation of brain. Westernization dietary habits in both developed and developing countries is accompanied by a progressive reduction intake PUFAs. Low maternal PUFAs has been linked to neurodevelopmental diseases epidemiological studies, but mechanisms which PUFA imbalance affects CNS development poorly understood. Active microglial engulfment synaptic elements an important process normal...
ABSTRACT Microglial phagocytosis is rapidly emerging as a therapeutic target in neurodegenerative and neurological disorders. An efficient removal of cellular debris necessary to prevent buildup damage neighbor neurons the development an inflammatory response. As brain professional phagocytes, microglia are equipped with array mechanisms that enable them recognize degrade several types cargo, including undergoing apoptotic cell death. While very competent phagocytes cells under physiological...