A5010802952- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Zebrafish Biomedical Research Applications
- Advanced Optical Sensing Technologies
- Animal Nutrition and Physiology
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Neurological Disease Mechanisms and Treatments
- Genetic and phenotypic traits in livestock
- Ocular and Laser Science Research
- Advanced Thermodynamics and Statistical Mechanics
- Advanced Fiber Laser Technologies
- Quantum Information and Cryptography
- Ion channel regulation and function
- Photochromic and Fluorescence Chemistry
- Thermal Radiation and Cooling Technologies
- Advanced Thermoelectric Materials and Devices
- Adenosine and Purinergic Signaling
- Nuclear Receptors and Signaling
- Signaling Pathways in Disease
- Ruminant Nutrition and Digestive Physiology
University of Bern
2021-2024
University of Tübingen
2016-2023
Nanjing Normal University
2010
South China Normal University
2007-2008
Anxiety plays a key role in guiding behavior response to potential threats. is mediated by the activation of pyramidal neurons ventral hippocampus (vH), whose activity controlled GABAergic inhibitory interneurons. However, how different vH interneurons might contribute anxiety-related processes unclear. Here, we investigate parvalbumin (PV)-expressing while mice transition from safe more anxiogenic compartments elevated plus maze (EPM). We find that PV increase their EPM concomitant with...
Abstract Microglia, resident immune cells of the brain, react to presence pathogens/danger signals with a large repertoire functional responses including morphological changes, proliferation, chemotaxis, production/release cytokines, and phagocytosis. In vitro studies suggest that many these effector functions are Ca 2+ -dependent, but our knowledge about in vivo signalling microglia is rudimentary. This mostly due technical reasons, as largely resisted all attempts labelling indicators....
Microglia arise from the yolk sac and enter brain during early embryogenesis. Upon entry, microglia undergo in situ proliferation eventually colonize entire by third postnatal week mice. However, intricacies of their developmental expansion remain unclear. Here, we characterize proliferative dynamics embryonic development using complementary fate-mapping techniques. We demonstrate that colonization is facilitated clonal highly microglial progenitors occupy spatial niches throughout brain....
Abstract Microglia, the major immune cells of brain, are functionally heterogeneous but in vivo functional properties these rarely studied at single‐cell resolution. By using microRNA‐9 regulated viral vectors for multicolor labeling and longitudinal monitoring individual microglia, we followed their fate cortex healthy adult mice onset amyloidosis a mouse model Alzheimer's disease. In wild‐type mice, microglia were rather mobile (16% migrated least once 10–20 days) had low turnover as...
Acquiring and exploiting memories of rewarding experiences is critical for survival. The spatial environment in which a stimulus encountered regulates memory retrieval. ventral hippocampus (vH) has been implicated contextual involving stimuli such as food, social cues or drugs. Yet, the neuronal representations circuits underlying socially are poorly understood. Here, using vivo electrophysiological recordings, one-photon calcium imaging, optogenetics during reward conditioning paradigm male...
Abstract The development and survival of adult-born neurons are believed to be driven by sensory signaling. Here, in vivo analyses motility, morphology Ca 2+ signaling, as well transcriptome juxtaglomerular cells with reduced endogenous excitability (via cell-specific overexpression either Kv1.2 or Kir2.1 K + channels), revealed a pronounced impairment migration, morphogenesis, survival, functional integration these into the mouse olfactory bulb, accompanied reduction cytosolic fluctuations,...
NRAGE, also denominated as MAGE-D1 or Dlxin-1, is firstly identified a molecule interacting with NGF low affinity receptor p75NTR. It facilitates cell cycle arrest and NGF-dependent neuronal apoptosis. Here we report that NRAGE downregulated while p75NTR upregulated during the process of NGF-induced differentiation PC12 cells. Knockdown by RNA interference accelerates NGF-mediated neurite outgrowth. In addition, in NRAGE-suppressed cells, ERK activation increased this MEK-dependent....
In this paper, the theoretical analysis and simulating calculation were conducted for a basic two-stage semiconductor thermoelectric module, which contains one thermocouple in second stage several thermocouples first stage. The study focused on configuration of cooler, especially investigating influences some parameters, such as current I1 stage, area A1 every number n cooling performance module. obtained results indicate that changing can improve These be used to optimize module provide...
Objective This experiment was conducted to determine the differences in apparent ileal (AID) and total tract digestibility (ATTD) of nutrients indispensable amino acids (IAA) high-fiber diets with wheat middlings, rice bran or alfalfa meal fed Duroc×(Landrace× Yorkshire) (DLY) Duroc× (Berkshire×Jiaxing) (DBJ) growing barrows. Methods Eighteen DLY 18 DBJ barrows were randomly allotted a 2×3 factorial arrangement involving 2 crossbreeds 3 diets. The lasted 15 d 10 for adaptation, feces...
This paper critically analyses and simulates the circuit configuration of integral gated mode single photon detector which is proposed for eliminating transient spikes problem conventional detector. The relationship between values elements effect cancellation has been obtained. With particular emphasis, bias voltage avalanche photodiode output signal integrator have calculated. obtained analysis results indicate that only relates to total quantity electricity charges by choosing correct time...
Abstract Acquiring and exploiting memories of rewarding experiences is critical for survival. The spatial environment in which a stimulus encountered regulates memory retrieval. ventral hippocampus (vH) has been implicated contextual involving stimuli such as food, social cues or drugs. Yet, the representations circuits underlying socially are poorly understood. Here, using vivo electrophysiological recordings during reward conditioning paradigm mice, we showed that vH neurons discriminate...
This paper introduces the design of a single photon detector based on AT89C51 chip microcontroller for quantum key distribution at telecommunication wavelengths. An avalanche photodiode (APD) is operated in Geiger mode and stabilized temperature 228K translating signals into electrical pulses. The induced pulses are amplified converted to digital data. discriminates data, counting number photons, then displays detection efficiency LCD display. instrument can effectively support study distribution.
SUMMARY Microglia are the resident immune cells of brain and arise from yolk sac-derived macrophages during early embryogenesis. On entering brain, microglia undergo in situ proliferation eventually colonise entire by second third postnatal weeks mice. However, intricate dynamics their developmental expansion remain unclear. Here, we examine characterise proliferative embryonic development. Using complementary fate-mapping techniques, demonstrate that colonisation is facilitated clonal...
Summary The development and survival of adult-born neurons is believed to be driven by sensory signaling. By genetically manipulating excitability cells (via cell-specific overexpression either Kv1.2 or Kir2.1 K + channels), longitudinal in vivo monitoring their Ca 2+ signaling transcriptome analyses, we show that endogenous but not sensory-driven activity governs migration, morphogenesis, survival, functional integration juxtaglomerular the mouse olfactory bulb. proper these required...