A5050200659- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Neurogenesis and neuroplasticity mechanisms
- Adenosine and Purinergic Signaling
- Complement system in diseases
- Lysosomal Storage Disorders Research
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Barrier Structure and Function Studies
- Glycogen Storage Diseases and Myoclonus
University of the Basque Country
2014-2020
Achucarro Basque Center for Neuroscience
2014-2020
Euskadiko Parke Teknologikoa
2014-2016
During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal but has an active role in maintaining neurogenesis. First, found neurogenesis was disrupted male female mice chronically deficient for two pathways: purinergic receptor P2Y12, tyrosine kinases TAM family Mer kinase (MerTK)/Axl. In contrast,...
Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory and autoimmune diseases, but its role the diseased brain poorly explored. Recent findings suggest that adult hippocampal neurogenic niche, where excess newborn cells undergo apoptosis physiological conditions, phagocytosis efficiently executed by surveillant, ramified microglia. To test whether microglia are efficient phagocytes as well, we confronted them with series apoptotic challenges discovered...
Abstract Apoptosis is a ubiquitous process occurring in the brain under both physiological and pathological conditions. The central nervous system (CNS) requires an active efficient clean‐up to prevent spillover of intracellular contents into surrounding parenchyma suppress initiation inflammatory immune responses. Microglia, resident professional phagocytes brain, are cells charge removal these dead by named phagocytosis. Therefore, microglial phagocytosis vital mechanism maintain tissue...
Abstract Objective Microglial phagocytosis of apoptotic cells is an essential component the brain regenerative response during neurodegeneration. Whereas it very efficient in physiological conditions, impaired mouse and human mesial temporal lobe epilepsy, now we extend our studies to a model progressive myoclonus epilepsy type 1 mice lacking cystatin B (CSTB). Methods We used confocal imaging stereology‐based quantification apoptosis hippocampus Cstb knockout (KO) mice, vitro siRNAs acutely...
SUMMARY During adult hippocampal neurogenesis, the majority of newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent spillover their intracellular contents. Here, we propose that phagocytosis is not merely a passive process corpse removal but has an active role in maintaining neurogenesis. First, found neurogenesis was disrupted mice chronically deficient for two microglial pathways (P2Y12 MerTK/Axl), transiently increased which MerTK expression...
ABSTRACT Microglial phagocytosis of apoptotic cells is an essential component the brain regenerative response in neurodegenerative diseases. Phagocytosis very efficient physiological conditions, as well during challenge induced by excitotoxicity or inflammation, but impaired mouse and human mesial temporal lobe epilepsy (MTLE). Here we extend our studies to a genetic model progressive myoclonus type 1 (EPM1) mice lacking cystatin B (CSTB), inhibitor cysteine proteases involved lysosomal...