A5059086452- Spaceflight effects on biology
- Renal function and acid-base balance
- Bone health and osteoporosis research
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Diet and metabolism studies
- Sodium Intake and Health
- Thermoregulation and physiological responses
- Nutritional Studies and Diet
- Medical and Biological Ozone Research
- Vitamin D Research Studies
- Effects of Vibration on Health
- Bone fractures and treatments
- Anesthesia and Neurotoxicity Research
- Climate Change and Health Impacts
- Hydrogen's biological and therapeutic effects
- Space Exploration and Technology
- Health and Well-being Studies
- High Altitude and Hypoxia
- Electrolyte and hormonal disorders
- Nitric Oxide and Endothelin Effects
- Orthopaedic implants and arthroplasty
- Body Composition Measurement Techniques
- Vitamin C and Antioxidants Research
- Parathyroid Disorders and Treatments
IU International University of Applied Sciences
2021-2023
University of Bonn
2011-2019
Wissenschaftliches Institut für Infrastruktur und Kommunikationsdienste
2019
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2003-2018
Université Sorbonne Paris Nord
2009
University of Minnesota
2009
University of Saskatchewan
2009
Newcastle University
2009
University of Reading
2009
New York University Press
2009
We examined, in immobilization, the effect of a diet high sodium chloride (NaCl) on bone markers, nitrogen balance, and acid-base status. Eight healthy male test subjects participated 14-day head-down-tilt bed rest (HDBR) study. During period they received, randomized crossover design, (7.7 meq Na + /kg body wt per day) low (0.7 NaCl diet. As expected, 24-h excretion urinary calcium was significantly greater high-NaCl-intake HDBR phase than low-NaCl-intake ( P < 0.001). High intake caused...
Abstract Context The effects of energy-balanced bed rest on metabolic flexibility have not been thoroughly examined. Objective We investigated the 21 days rest, with and without whey protein supplementation, while maintaining energy balance. hypothesized that supplementation mitigates inflexibility by preventing muscle atrophy. Design Setting Randomized crossover longitudinal study conducted at German Aerospace Center, Cologne, Germany. Participants Interventions Ten healthy men were...
The aim of the study was to analyze kinetics short-term changes in bone turnover. We studied a randomized crossover design effects 6 days bed rest on eight healthy male subjects (mean body wt: 70.1 ± 5.7 kg; mean age: 25.5 2.9 yr). metabolic ward period divided into three parts: 4 ambulatory days, either or non-bed periods, and 1 recovery day. diet identical both phases. Continuous urine collection started first day excretion resorption markers, namely C-telopeptide (CTX) N-telopeptide...
Abstract Stepwise increase in NaCl intake healthy male test subjects led to a low-grade metabolic acidosis. This was most likely the cause for increased bone resorption during high sodium chloride intake, as determined by analyzing markers. Introduction: We examined effect of dietary (NaCl) on metabolism and acid-base balance. Materials Methods: Subjects were nine men (mean age, 25.7 ± 3.1 yr; mean body weight [BW], 71.5 4.0 kg). During first period (6 days), received 0.7 mEq NaCl/kg BW per...
We report results from a study designed to explore the utility of artificial gravity (AG) as countermeasure bone loss induced by microgravity simulation. After baseline testing, 15 male subjects underwent 21 days 6 degrees head-down bed rest simulate deconditioning associated with spaceflight. Eight 1 h centrifugation (AG; G(z) at heart, 2.5 feet) each day for days, whereas seven served untreated controls (Con). Blood and urine were collected before, during, after marker determinations. Bone...
Contrasting data are published on the effects of high salt intake (between 300 and 660 mmol/d) Na balance fluid retention. In some studies levels NaCl (400, 440, 550 led to positive balances without To test relevance different baseline changes in metabolic water, Na, K, chloride acid–base balance, a 28 d clinical trial ('Salty Life 6') was carried out ward. Nine healthy male volunteers (aged 25·7 (sd 3·1) years; body mass (BM) 71·4 4·0) kg) participated present study. Four consecutive...
OPINION article Front. Immunol., 11 October 2019Sec. Nutritional Immunology Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.02407
Previously published data (J Bone Miner Res (2005); 20: 471) did not give evidence that the administration of nitric oxide precursor L-arginine increases bone formation and decreases resorption in postmenopausal women. Data this trial were reanalysed for putative effects on muscle mass muscular function. Therefore, 11 females former study group (n=15; age 54.5+/-4.1 years; daily oral 18 g hydrochloride (equivalent 14.2 L-arginine) over 6 months) 12 control 55.3+/-4.4 dextrose analysed...
Bed rest (BR) causes bone loss, even in otherwise healthy subjects. Several studies suggest that ambulatory subjects may benefit from high-protein intake to stimulate protein synthesis and maintain muscle mass. However, increasing above the recommended daily without adequate calcium potassium increase resorption. We hypothesized a regimen of (HiPROT), applied an isocaloric manner during BR, with meeting values, would prevent any effect BR on turnover. After 20-day adaptation controlled...
Aim . We hypothesized that 4 days of normal daily activity after 21 experimental bed rest (BR) will not reverse BR induced impaired glucose tolerance. Design Glucose tolerance seven male, healthy, untrained test subjects (age: 27.6 (3.3) years (mean (SD)); body mass: 78.6 (6.4) kg; height: 1.81 (0.04) m; VO 2 max: 39.5 (5.4) ml/kg mass/min) was studied. They stayed twice in the metabolic ward (crossover design), and 7 before each. Oral tests were applied before, on day BR, 5 14 BR. Results...
Abstract NO is an important regulator of bone turnover. L-Arginine, the natural precursor NO, can enhance production. However, no effect L-arginine hydrochloride supplementation was found on metabolism or BMD, mass, structure healthy postmenopausal women. Introduction: Recent studies indicate that exerts anabolic cell activity. The level human body be elevated by administering pharmacological donors. Animal and first trial showed donor administration had a positive formation negative...
Abstract Dietary countermeasures to mitigate detrimental spaceflight‐induced effects on bone health would alleviate the requirements and consequences imposed by other types of for this risk. We hypothesised that antioxidant supplementation during 60 days 6° head‐down tilt bed rest (HDBR), an analogue spaceflight, have a protective effect mineral density (BMD), content (BMC) structure parameters. An exploratory, randomised, controlled, single‐blind intervention trial was conducted in parallel...