A5004737222- Spaceflight effects on biology
- High Altitude and Hypoxia
- Human Health and Disease
- Exercise and Physiological Responses
- Medical and Biological Ozone Research
- Pediatric health and respiratory diseases
- Space Exploration and Technology
- Immune Response and Inflammation
- Stress Responses and Cortisol
- Climate Change and Health Impacts
- Thermoregulation and physiological responses
- Gut microbiota and health
- Bone health and osteoporosis research
- Neonatal Respiratory Health Research
- Bone Metabolism and Diseases
- Hydrogen's biological and therapeutic effects
- Digestive system and related health
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Genetics, Aging, and Longevity in Model Organisms
- Immune responses and vaccinations
- Respiratory Support and Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mitochondrial Function and Pathology
- Cardiovascular and Diving-Related Complications
Institute of Biomedical Problems
2016-2025
Federal Medical-Biological Agency
2022
Sechenov University
2022
Russian Academy of Sciences
2012-2020
Space flight exerts a specific conglomerate of stressors on humans that can modulate the immune system. The mechanism remains to be elucidated and consequences for cosmonauts in long term are unclear. Most current research stems from short-term spaceflights as well pre- post-flight analyses due operational limitations. Immune function 12 participating long-duration (>140days) spaceflight mission was monitored pre-, post-, two time-points in-flight. While classical markers stress such...
Abstract Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types human body. Here, we propose that a parallel Space could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit permit advent of precision spaceflight healthcare. Alongside scientific potential, consider...
OPINION article Front. Immunol., 11 October 2019Sec. Nutritional Immunology Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.02407
Further development of manned space exploration requires appropriate scientific and modern methodological approaches assessing the health risks participants in missions to an orbital station with high inclination orbit interplanetary missions. The "Environmental Scanning" as well available Internet sources (PubMed EMBASE; 198 relevant publications) personal messages, followed by expert discussion within framework interdisciplinary working group were used assess contemporary spaceflight risk...
The complex of spaceflight factors has a significant impact on the immunity functional activity. This influence is probably caused by such as isolation, monotony, physical inactivity, sensory deprivation, and increased psycho-emotional tension. Long-term wintering at polar stations can be ground-based model that most similar to space flight conditions. research focused examining reactivation latent human pathogens among 11 participants 64th Russian Antarctic expedition Vostok station....
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Abstract Environmental factors have long been known to influence immune responses. In particular, clinical studies about the association between migration and increased risk of atopy/asthma provided important information on role associated large sets environmental exposures in development allergic diseases. However, investigations effects responses are mostly limited candidate exposures, such as air pollution. The influences still largely unknown. A simulated 520-d Mars mission an...
The system of signaling pattern recognition receptors was studied in 8 cosmonauts aged 35 to 56 years before and after (R+) long-duration missions the International space station. Peripheral blood samples were analyzed for content monocytes granulocytes that express Toll- like (TLR) localized as on cell surface (TLR1, TLR2, TLR4, TLR5, TLR6), so inside cells (TLR3, TLR8, TLR9). In parallel, serum concentrations TLR2 (HSP60) TLR4 ligands (HSP70, HMGB1) measured. results investigations showed...
Space flight factors are known to cause a malfunction in the human immune system and lead damage blood vessels. The hemostatic function of endothelium during space missions its interaction with immunity has not been determined so far. In this work, we investigated markers endothelial activation (plasma concentrations soluble thrombomodulin fraction (sTM), von Willebrand factor (vWF), highly sensitive C-reactive protein (hs-CRP)), as well level D-dimer compared them immunological parameters...
Medical support is one of the essential safety conditions for isolation or confinement experiments, as it enables timely arrangement actions to preserve health crew members and volunteers. Such analog experiments allow testing prospective medical technologies methods in long-term space missions on-planet stations. In current paper, we report results control within system two model SIRIUS series, lasting 4 8 months, respectively. The indicate prevalence headache complaints, skin inflammatory...
The next steps of deep space exploration are manned missions to Moon and Mars. For safe for crew members, it is important understand the impact flight on immune system. We studied effects 21 days dry immersion (DI) exposure transcriptomes T cells isolated from blood samples eight healthy volunteers. Samples were collected 7 before DI, at day 7, 14, during after DI. RNA sequencing CD3+ revealed transcriptional alterations across all time points, with most changes occurring 14 DI exposure. At...
During space missions cosmonauts are exposed to a myriad of distinct stressors such as radiation, overloads, weightlessness, isolation in artificial environmental conditions, which causes changes immune system. flights it is very difficult determine the particular factor associated with observed immunological responses. This makes ground-based experiments examining effect each flight along value. Determining mechanisms causing alterations cosmonauts' immunity can lead potential targets for...