A5101601540- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Cyclopropane Reaction Mechanisms
- Iron Metabolism and Disorders
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Hemoglobinopathies and Related Disorders
- Nanoplatforms for cancer theranostics
- Organophosphorus compounds synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Acute Ischemic Stroke Management
- Cancer-related gene regulation
- Blood properties and coagulation
- Esophageal and GI Pathology
- Spatial Cognition and Navigation
- Quantum Dots Synthesis And Properties
Division of Chemistry
2025
Material (Belgium)
2025
Xi'an Jiaotong University
2021-2025
University of Jinan
2024
Xiamen University
2007-2021
China XD Group (China)
2021
Centre for Sustainable Energy
2021
Tianjin University
2018-2019
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2018-2019
Children’s Hospital of Fudan University Xiamen Branch
2019
The development of bromodomain and extraterminal domain (BET) inhibitors their examination in clinical studies, particularly oncology settings, has garnered substantial recent interest. An effort to generate novel BET with excellent potency drug metabolism pharmacokinetics (DMPK) properties was initiated based upon elaboration a simple pyridone core. Efforts develop bidentate interaction critical asparagine residue resulted the incorporation pyrrolopyridone core, which improved by 9–19-fold....
Mesoporous silica nanocarriers (MSNs) are appealing in terms of their large cavity surface area and high loading capacity, but they have been suffering from premature cargo release. Herein, we report a gated smart MSN that is sensitive to low oxygen concentration (i.e., hypoxia) via taking advantage the superior electron-accepting ability azobenzene moiety. The polymer was employed as responsive gate-keeper deposited on surface, followed by coating with amphiphilic Pluronic F68 for steric...
Resent studies have identified Pygopus as a core component of the β-catenin/T-cell factor (TCF)/lymphoid-enhancing 1 (LEF) transcriptional activation complex required for expression canonical Wg/Wnt target genes in Drosophila. However, biochemical involvement mammalian proteins β-catenin/TCF/LEF gene remains controversial. In this study, we perform series molecular/biochemical experiments to demonstrate that Pygo2 associates with histone-modifying enzymatic complexes, specifically MLL2...
A class of prearomatic carboxylic acid p-quinol ester radical precursors has been developed successfully, which could undergo homolytic cleavage the para C-O bond esters via pyridine-boryl radical-induced aromatization in presence pyridines and diboron reagents, affording corresponding alkyl decarboxylation from carboxyl situ. In addition, were further applied substitution with phenylsulfonyl compounds self-coulpings. This method not only provides a new approach to generation intermediate...
A Ru(II)-catalyzed cis carbohalogenation and carbooxygenation cyclization of internal alkyne-tethered cyclohexadienones has been developed, which provided a novel approach to synthesize tetrasubstituted alkenes via aromatization cross-couplings.
A rhodium-catalyzed diastereoselective formal [5 + 2] annulation of indoles with cyclohexadienone-containing 1,6-enynes has been established via indole 2,3-difunctionalization. The reaction, probably proceeding through tandem C2–H alkenylation and intramolecular Friedel–Crafts alkylation relay, provides rapid construction indole-fused oxepines in good to excellent yields a broad substrate scope. This method also features concomitant cis-hydrobenzo[b] oxepine scaffolds, core unit found...
Singlet oxygen can trigger the oxidation of nitroimidazole-bearing micelles for on-demand cargo release.
An efficient regioselective and stereoselective cascade annulation of indoles with alkynediones has been developed for construction free (NH) tetrahydrocarbazoles continuous quaternary carbons <italic>via</italic> Cp*Rh<sup>III</sup>-catalyzed indole C2–H activation.
A highly efficient iodine anion catalyzed cross-dehydrogenative aromatization of cyclohexenones with amines has been developed under metal-free conditions, which affords aromatic in good to excellent yields a broad substrate scope. Meanwhile, this reaction provides new method for the construction C(sp2)–N bonds and also strategy slow generation oxidants or electrophiles via situ dehalogenation. Moreover, protocol rapid concise approach chiral NOBIN derivatives.
An efficient Cp*RhIII-catalyzed formal C(sp3)–H activation/spiroannulation of alkylidene Meldrum's acids with alkynes has been developed using catalytical Cu(OAc)2 and air as the oxidant. This reaction demonstrates a new straightforward approach to spirocyclopentadienes acid moieties in good excellent yields under mild conditions broad substrate scope. Notably, this protocol provides novel cyclopentadienes various substitution patterns corresponding cyclopentadienyl-type ligands from simple...
We have established an efficient ruthenium(II) and iodine anion cocatalyzed dihalogenation cascade cyclization of internal alkyne-tethered cyclohexadienones, which stereoselectively afforded numerous products with a bioactive hydrobenzofuran skeleton in high yields under mild conditions. In this transformation, the reaction pathway was determined by concentration electrophilic reagent, also provided strategy for control selectivity. Furthermore, method features use 1,2-dihaloroethane as...
To observe changes in the complete blood count (CBC) venous parameters of healthy children and establish appropriate reference intervals (RIs).Overall, 4066 were selected divided into four groups: infants, toddlers, preschool-age school-age children. Venous was analysed for 17 parameters. Outlier data each parameter eliminated RIs established based on Clinical Laboratory Standards Institute C28-A3c guideline.The certain differed among different age groups. The white cell (WBC) variation...
A highly efficient cascade cyclization of phenidones and enynones has been developed via a Ru(II)-catalyzed C-H activation initiated indole formation/Diels-Alder reaction/iminium ion sequence, which afforded hexacyclic indolines as single diastereomer in good to excellent yields with broad substrate scope under mild conditions. The reaction features the simultaneous generation five new chemical bonds four rings one pot, providing rapid concise approach toward polycyclic indoline alkaloids...
An efficient copper-catalyzed method for the synthesis of quinolinones, pyridinones, and heteroannulated pyridinones via cascade reactions substituted 2-iodo-, 2-bromo-, 2-chlorobenzocarbonyls with 2-arylacetamides is reported. The protocol works well reaction most 2-bromo- 2-arylacetamides.
In this paper, an electrochemiluminescence (ECL) encoding method was developed for the first time, based on a dual-dye system including Ru(bpy)32+ as ECL emitter and fluorescein isothiocyanate (FITC) coding dye.
Abstract Polymeric microcapsules have begun to attract significant interest in biomedical fields. As the interactions between cells and materials are influenced by both cell type elasticity, silk‐based synthesized with desirable mechanical features using layer‐by‐layer assembly then uptake of these BeWo b30 placental is investigated. Cellular enhanced increasing elastic modulus microcapsules. More importantly, distinct microvilli behaves a diverse manner when exposed different features,...
Abstract The scope is investigated providing a straightforward preparation of quinolinone, pyridinones, and heteroannnulated analogues in moderate to good yields.
Objective . Diagnostic colonoscopy is important for diagnosing colorectal diseases, including inflammatory bowel disease and tumours. Perforation during diagnostic colonoscopy, a rare but serious complication, considerable factor before performing the procedure. Immediate endoluminal closure of perforation could prevent adverse consequences associated with general anaesthesia surgery. This study aimed at assessing potential effectiveness safety endoscopic band ligation (EBL) in closing colon...
A highly efficient Ru(II)-catalyzed regio- and stereospecific hydro-oxycarbonylation of unsymmetrical internal alkynes bearing a difunctional 2-pyridyloxy directing group with carboxylic acids has been developed, which provides allylic (Z)-enol esters in good to excellent yields broad substrate scope under mild conditions. The can be diversely derivatized, particularly undergoing substitution various nucleophiles afford β-functionalized without groups.
Abstract The BET family of proteins consists BRD2, BRD3, BRD4 and BRDT, with each these containing two distinct bromodomains (BDI BDII). ABBV-075, like other first generation bromodomain inhibitors currently under clinical development, binds to the 8 similar affinity inhibits proliferation cancer cells that represent a wide range tumor types. We hypothesized selectively targeting specific subsets might abolish this broad spectrum profile such only types are highly addicted subtype...
This thesis researches how the interactive design rebranding tourism brands. It proposes use of augmented reality cascading technology and multi-dimensional information display to sort out human information, geographic ecological cultural traditions other for tourist destinations, finally Professional development displays this in a visual design. study mainly discusses from three aspects: 1. Augmented enables experience realize transformation surface three-dimensional; 2. enhances...