A5100666804- Nanoparticle-Based Drug Delivery
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Reconstructive Facial Surgery Techniques
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Silk-based biomaterials and applications
- Nasal Surgery and Airway Studies
- Polymer Surface Interaction Studies
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Ear Surgery and Otitis Media
- Cancer-related Molecular Pathways
- Allergic Rhinitis and Sensitization
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Circular RNAs in diseases
- Diabetic Foot Ulcer Assessment and Management
- Gold and Silver Nanoparticles Synthesis and Applications
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
Beijing Obstetrics and Gynecology Hospital
2014-2025
Capital Medical University
2014-2025
Tongji Hospital
2007-2025
Huazhong University of Science and Technology
2007-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
University of Florida
2023
People's Hospital of Xinjiang Uygur Autonomous Region
2022
First People’s Hospital of Zunyi
2020-2022
Zunyi Medical University
2020-2022
The soybean phytoestrogen, genistein (Gen), has anabolic effects on bone through mechanisms that remain to be elucidated. We examined the role of nitric oxide (NO) and its downstream effector guanylyl cyclase (GC) in mediating Gen proliferation osteoblastic maturation primary mouse marrow-derived mesenchymal stem cells (BMSCs). (10(-8) approximately 10(-6) M) resulted a dose-dependent increase cell as measured by increased [3H]thymidine incorporation, stimulated assessed culture...
Fracture is one of the most pervasive injuries in musculoskeletal system, and there a complex interaction between macrophages adipose tissue-derived stem cells (ADSCs) fracture healing. However, two-dimensional (2D) coculture ADSCs can not accurately mimic vivo cell microenvironment. To establish both 2D 3D osteogenic models to investigate ADSCs. After obtaining from surgery inducing differentiation THP1 line, we established models. assess level differentiation, used alizarin red staining...
Introduction: Nanomedicine has shown a great potential in perinatal medicine because of its characteristics sustained, controlled release and targeting ability; on the other hand, it may also lead to unexpected toxicities such as embryotoxicity even malformation after crossing placental barrier, but data concerning transplacental transport are scarce. Pullulan acetate (PA) nanoparticles (NPs) promising nanocarrier derived from natural polysaccharide; however, their ability mechanism unknown....
Effect of inhibitors endocytosis and NF-kB signal pathway on folate-conjugated nanoparticle by rat Kupffer cells Hongbo Tang,1 Hongli Chen,2 Yajing Jia,2 Xiaoyan Liu,1 Zhaohong Han,1 Aihua Wang,1 Qi Xinlei Li,1 Xin Feng1 1Department Pharmacy, Beijing Obstetrics Gynecology Hospital, Capital Medical University, Beijing, 2School Life Sciences Technology, Xinxiang Xinxiang, Henan, People's Republic China Abstract: The regular accumulation nanoparticles in the liver makes them hepatotoxic...
Based on our previous work the PLGA nanoparticles modified with biotinylated chitosan (Bio-CS-PLGA NPs), we further studied stability, toxicity, pharmacokinetics, and in vivo efficacy. The safety of NPs was through single-dose toxicity test mice, result showed that were well tolerated at dose 300 mg/kg. Compared free EPB group, group exhibited higher plasma drug concentration, longer half-life time. EPB-loaded significantly inhibited tumor growth compared to EPB. All results suggested...
The effects of immune cells, in particular macrophages, on the behaviour mesenchymal stromal cells (MSCs) have recently gained much attention for MSCs-based tissue-engineered constructs. This study aimed to evaluate effect monocytes/macrophages osteogenic differentiation adipose-derived (ADMSCs) three-dimensional (3D) cocultures. For this, we cocultured THP-1 monocytes, M1 or M2 macrophages with ADMSCs 3D poly(lactic-co-glycolic) acid (PLGA)/polycaprolactone (PCL) scaffolds using medium up...
Background This study aims to develop a diabetic retinopathy (DR) hazard nomogram for Chinese population of patients with type 2 diabetes mellitus (T2DM). Methods We constructed model by including data from 213 T2DM between January 2019 and May 2021 in the Affiliated Hospital Zunyi Medical University. used basic statistics biochemical indicator tests assess risk DR T2DM. The patient were evaluate using R software least absolute shrinkage selection operator (LASSO) predictive model. Using...
Background Microtia is a congenital abnormality varying from slightly structural abnormalities to the complete absence of external ear. However, there no gold standard for assessing severity microtia. Objectives The purpose this study was develop and test models artificial intelligence assess microtia using clinical photographs. Methods A total 800 ear images were included, randomly divided into training, validation, set. Nine convolutional neural networks (CNNs) trained classifying...
We explored the role of insulin-like growth factor 1 (igf-1) in development lung cancer.We used immunohistochemistry to measure expression igf-1 and receptor (igf-1r) specimens tissue perioperative circulation from 80 patients with primary non-small-cell cancer (nsclc) 45 benign pulmonary lesions (bpls). Correlations those measurements clinicopathologic characteristics clinical follow-up were analyzed. Circulating was measured before after surgery all patients.Compared bpl specimens, nsclc...
Single-component porous silk microcapsules were synthesized by the one-step desolvation method using PLGA spheres as sacrificial templates. Subsequently, AuNRs–T5 utilized to synthesize silk-based hybrid capsules, which not only capped pores of shell but also enhanced Raman scattering.
Conventional cell-based bone regeneration suffers from the major disadvantage of limited cell supply, time-consuming in vitro expansion cultures, and patient-friendliness related to isolation multiple visits clinic. Here, we utilized an alternative concept using "easy access cells" that can be obtained intraoperative manner prepare constructs. We used stromal vascular fraction (SVF) human adipose tissue monocytes for preparation constructs grafted with expanded mesenchymal stem cells...
Background: Sudden sensorineural hearing loss (SSNHL) may occur during pregnancy with a rare prevalence, and little is known about it.Aims: To retrospectively analyze cases of SSNHL investigate their clinical characteristics, management outcome.Material methods: Records 30 patients were reviewed, including age, localization, duration from onset to treatment, gestation period, accompanying symptoms, initial threshold, final audiogram, treatment outcome.Results: Twenty-four (80.0%) suffered in...
It is recognized that the stability and journey in body of nanoparticles are important issues for drug formulations. In this study, we prepared folate-conjugated pullulan acetate (FPANs) epirubicin loaded FPANs (FPA/EPI) using dialysis method. The storage FPA/EPI at 4 degrees C could be up to 3 months. Using folate receptor overexpressed Hela cells, dose dependent cellular uptake receptor-mediated endocytosis were confirmed. From vivo pharmacokinetics test, compared free EPI, half-life time...