A5101544245- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Microbial Metabolic Engineering and Bioproduction
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Molecular Sensors and Ion Detection
- Viral Infectious Diseases and Gene Expression in Insects
- Entomopathogenic Microorganisms in Pest Control
- Drug Solubulity and Delivery Systems
- Protein Hydrolysis and Bioactive Peptides
- Algal biology and biofuel production
- Insect Resistance and Genetics
- Pharmacological Effects of Natural Compounds
- Amino Acid Enzymes and Metabolism
- Streptococcal Infections and Treatments
- Proteins in Food Systems
- Herpesvirus Infections and Treatments
- Viral Infections and Immunology Research
- Sulfur Compounds in Biology
- Oral microbiology and periodontitis research
- Influenza Virus Research Studies
- Luminescence and Fluorescent Materials
- Polyamine Metabolism and Applications
- Plant biochemistry and biosynthesis
- Biofuel production and bioconversion
Nanjing Normal University
2025
Chinese Academy of Sciences
2009-2025
Chinese Academy of Agricultural Sciences
2016-2025
Shanghai Veterinary Research Institute
2015-2025
Shanghai Institute of Materia Medica
2025
University of Chinese Academy of Sciences
2019-2025
Xinyang Normal University
2024
Yangzhou University
2022-2024
Northeast Agricultural University
2022-2024
Max Planck Institute of Molecular Plant Physiology
2021-2024
Microalgae are highly efficient cellular factories that capture CO2 and also alternative feedstock for biofuel production. Carbohydrates, proteins, lipids major biochemical components in microalgae. Carbohydrates or starch microalgae possible substrates yeast fermentation The carbon partitioning could be regulated through environmental stresses, such as high concentration of CO2, light intensity, nitrogen starvation conditions. It is essential to obtain carbohydrate-rich via an optimal...
In the thick of it: A carbazole-based cyanine derivative has been used as a ratiometric fluorescent sensor to detect mitochondrial viscosities over range 1–950 cP within live cells and living tissues by using two-photon microscopy. Its success is based on fast- low-barrier rotation around its methine bond (see figure) huge increase fluorescence quantum yield (QY) from loss mobility in viscous media.
In the present study, a novel pentapeptide LPLLR (Leu-Pro-Leu-Leu-Arg) was purified and identified from walnut protein hydrolysates (3–10 kDa) by SEC, RP-HPLC, LC-MS/MS. Its inhibitory actions against α-glucosidase α-amylase were evaluated. Then its beneficial effects on glucose metabolism underlying molecular mechanism determined in high glucose-induced insulin resistant (IR) hepatic HepG2 cells. Results demonstrated that could inhibit both α-amylase, inhibition rate reached maximum of...
Licorice (Glycyrrhiza glabra) is extensively used owing to the superior pharmacological effects. However, its maximum application potential has not been fully exploited due limitation of currently available extraction solvent and methods. In this study, an eco-friendly deep eutectic (NADESs) based ultrasound-assisted (DES-UAE) method was applied prepare licorice extracts. The DES-UAE using choline chloride lactic acid as optimized modeled by response surface methodology maximize yields...
ABSTRACT Streptococcus suis ( S. ) has been increasingly recognized as a porcine zoonotic pathogen that threatens the health of both pigs and humans. Multidrug-resistant is becoming prevalent, novel strategies to treat bacterial infections caused by these organisms are desperately needed. In present study, an untargeted metabolomics analysis showed significant decrease in methionine content biosynthetic pathway were significantly affected Kyoto Encyclopedia Genes Genomes enrichment...
A new dye, PTZ-Cy2, based on a hybrid cyanine–phenothiazine platform, is described. Oxidation by highly reactive oxygen species (hROS) involves attack at the thiazine sulfur atom and destruction of π conjugation cyanine moiety. Dual fluorescence emissions are enhanced dramatically λem 470 nm 595 nm, PTZ-Cy2 thus serves both as an absorbance ratiometric fluorescent "off–on" sensor for detecting hROS. Moreover shows selectivity hROS over other oxidants, gives sensitive response to such...
Oxidative stress is an important factor in the pathogenesis of insulin resistance (IR) type 2 diabetes mellitus (T2DM). Bioactive peptides from nuts have been shown to alleviate oxidative and IR. However, specific mechanisms underlying their activity remain unclear. This study investigated protective effects three novel derived Juglans mandshurica Maxim., LVRL, LRYL, VLLALVLLR, against high glucose-induced IR HepG2 cells. The possible these were also elucidated. walnut-derived improved...
A selenium-contained fluorescent 'turn-on' probe D-HMSe was developed for monitoring hydrogen peroxide. The is highly selective to peroxide over other reactive oxygen species (ROS). An aggregation-induced enhancement (AIE) phenomenon involved in the sensing process.
Biosynthesis of sabinene, a bicyclic monoterpene, has been accomplished in engineered microorganisms by introducing heterologous pathways and using renewable sugar as carbon source. However, the efficiency titers this method are limited low host tolerance to sabinene (in both eukaryotes prokaryotes).In study, Escherichia coli BL21(DE3) was selected strain for adaptive laboratory evolution. The evolved serial passaging medium supplemented with gradually increasing concentration XYF(DE3),...
Background: Paidu powder (PDP) is a formula that used in traditional Chinese medicine (TCM) practices and has been demonstrated to be effective lower blood uric acid (UA) level. Methods: Network pharmacology was employed probe the mechanistic basis for beneficial effects of PDP. Then, PDP subjected Aspergillus oryza AS3.042 fermentation, primary bioactive compounds resultant samples were analyzed via HPLC. A clinical study then performed test therapeutic unfermented fermented on HUA....
Porcine epidemic diarrhea, as a porcine diarrhea virus (PEDV)-induced infectious intestinal condition typified by emesis, dehydration, and anorexia, leads to death rates high 100% among suckling piglets. Given the existing commercial vaccines, it is essential study host-virus interactions formulate efficient anti-viral regimes. This concerned host factor POLM (a DNA polymerase family member) that exerts an effect against PEDV proliferation. Our results indicated expression was increased...
Lily flowers are widely used in China for lung nourishment; however, their active ingredients remain unknown. To address this question, we isolated a novel polysaccharide (L005-B) from the of Lilium lancifolium. Its backbone is comprised Glcp, Galp, and 1,2-linked α-Rhap. The branch composed Xyl T-α-Glcp residues substituted at C-4 position Rhap, along with portions Araf, GlcpA glucose or C-3 galactose. Bioactivity study showed that L005-B alleviated fibrosis-associated protein (fibronectin,...