Trametenolic acid B (TAB) was a lanostane-type triterpenoid isolated from the trametes lactinea (Berk.) Pat. We have previously reported that extract Pat and TAB could efficiently improve learning memory ability of cerebral ischemia injury rats suppress mitochondrial-mediated apoptosis in hydrogen peroxide damaged SH-SY5Y cells. However, potential mechanisms not been fully understood yet. The current study to further investigate protective effect on oxygen glucose deprivation/reoxygenation...

Total flavonoids of Epimedium (TFE) is the main active composition that has been used to treat male reproductive problems. The present aim was investigate protective effects TFE on mice system against cyclophosphamide (CP)‐induced oxidative injury. animals were treated with CP make testicular injury model and observed. In CP‐treated group, epididymal weights, sperm count motility significantly decreased relative control group ( P < 0.05 0.01, respectively). Compared (200 400 mg/kg)...

Abstract Objective Inflammation is widely acknowledged to increase morbidity and mortality in myocardial infarction (MI), the ideal therapeutic methods should be aimed at inflammation reaction triggers. The aim was evaluate protective effect of saponins extracted from Panax japonicus (SPJ) on MI, based these results investigate possible involvement mechanism nuclear factor-kappa B (NF-κB), sirtuin1 (SIRT1) mitogen-activated protein kinases (MAPKs) signalling pathways. Methods Sprague-Dawley...

Trametenolic acid B (TAB), the bioactive component in Trametes lactinea (Berk.) Pat, was reported to possess cytotoxic activities and thrombin inhibiting effects. This study performed investigate effects of TAB on H(+)/K(+)-ATPase gastric cancer. The inhibitory activity determined by parietal cells. Compared normal control group, (10, 20, 40 80 μg/mL) inhibited 15.97, 16.96, 24.86 16.25%, respectively. In study, 36 Kunming mice were randomly divided into six groups: control, model, TAB-L...

Introduction: Nanomedicine has shown a great potential in perinatal medicine because of its characteristics sustained, controlled release and targeting ability; on the other hand, it may also lead to unexpected toxicities such as embryotoxicity even malformation after crossing placental barrier, but data concerning transplacental transport are scarce. Pullulan acetate (PA) nanoparticles (NPs) promising nanocarrier derived from natural polysaccharide; however, their ability mechanism unknown....

The present study was to the hepatoprotective effects of phloridzin (PHL) on hepatic fibrosis induced by carbon tetrachloride (CCl4) in rats, basis this investigation, possible mechanism PHL elucidated. Male Sprague Dawley (SD) rats were randomly divided into six groups: control, model, PHL-L, PHL-M, PHL-H and colchine. All except control group intraperitoneally injected with CCl4, olive oil, twice a week for eight weeks. At same time, orally given homologue drugs once day, respectively....

Direct N-glycosylation between glycals and amides/amines was achieved with exclusive stereoselectivity in moderate to high yields. Various amides, amines, 3,4-O-carbonate-glycals were tolerated, unique β-N-glycosides obtained. The strategy based on palladium-catalyzed decarboxylative allylation, the 1,4-cis-selectivity proposed because of hydrogen bonding effect. Notably, all synthesized products subjected preliminary bioactivity studies, revealing that three compounds cytotoxic tumor cells...

Reactive oxygen species can induce cell apoptosis, and oxidative stress has been implicated in a variety of neurodegenerative disorders. Tomatine, which is naturally occurring steroidal glycoalkaloid isolated from Solanum cathayanum, shown potent anti-oxidant properties.In this study, we used the SH-SY5Y line as an vitro model investigated protective effect tomatine against hydrogen peroxide (H2 O2 )-induced neurotoxicity cells.Tomatine might inhibit release cellular lactate dehydrogenase,...

The present study was conducted to investigate whether hydroxysafflor yellow A (HSYA) has a protective effect on acute and chronic heart failure (AHF/CHF) induced by ligation of the left anterior descending coronary artery for 3 h 8 weeks, respectively. rats were divided into following groups: sham operation, (CAL), CAL+HSYA (100 mg kg(-1) gavage) CAL+diltiazem (20 gavage). In AHF model, function, as determined haemodynamic studies echocardiography, improved significantly pretreatment with...

Trametenolic acid B (TAB) is the main active composition of Trametes lactinea (Berk.) Pat which possesses antitumor activities. There was no report its effect through regulating P-glycoprotein (P-gp) so far, due toP-gp over expression one most important mechanisms contributing to multiple drug resistance phenotype. The present aim investigate effects TAB on P-gp in multidrug-resistant cells;Paclitaxel-resistant cell line MDA-MB-231/Taxol established by stepwise exposure for 10...

Abstract Objectives Our previous studies indicated that the triterpenes from fruits of Chaenomeles speciosa (Sweet) Nakai (TCS) owned effectively therapeutic effects on gastric ulcer patients and animals, but its mechanisms have not been fully understood. The current study was to further investigate protective effect indomethacin (IND)-damaged RGM-1 cells rats, as well involved. Methods gastroprotection TCS evaluated with IND-induced lesions model in rats. In vitro, proliferation, migration,...

We aimed to investigate the effects of Liuwei Dihuang decoction (LW) on endothelin-1-reactive oxidative species (ET-ROS) system and matrix metalloproteinases (MMPs) in early diabetic nephropathy induced by streptozotocin (STZ) rats. Rats were divided into six groups as follows: control group, untreated model treated with LW (5, 10 15 g kg(-1), p.o.) aminoguanidine-treated group (100 mg orally). The treatment was performed for 4 weeks, beginning fifth week after one intraperitoneal injection...

Reineckia carnea has been used to treat several diseases in folk remedies. RCE-4 isolated from plants of the family Liliaceae, but its biological activity not yet reported. In present study, we found that exhibited potent cytotoxicity tested human cancer cell lines, and CaSki line was most sensitive with an IC50 3.37 µM. Thus, presented apoptosis-inducing effect on cervical cells investigated relevant mechanisms. Based observations using transmission electron microscopy, RCE-4-treated...

Background. Cinobufagin has been widely used in the treatment of carcinoma and plays an important role relief cancer pain. But involved mechanism remains unknown. Aim. To investigate changes thermal mechanical hyperalgesia paw pain mice action cinobufagin using a model. Methods. 60 female were randomly divided into 5 groups: control group, model +NAL-M morphine group; except ones inoculated with H22 hepatoma cells right hind paw. From 9th day after inoculation, administrated drug once daily...

Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in plant-associated fungus Xylaria sp., effect of culture conditions on metabolite production was investigated. A shift five known cytochalasin-type analogues 1–5 six new α-pyrone derivatives, xylapyrones A–F (compounds 6–11), from solid liquid medium observed. These were identified by analysis 1D and 2D NMR HRMS data. Compounds 1–3 showed moderate cytotoxicity against HepG2 Caski cancer cell...

Abstract Acute heart failure (AHF) critically affects morbidity and mortality in patients suffering from septic shock. It is hypothesized that AHF linked to down-regulation of FKBP12.6 (calstabin 2) SERCA2a (sarco/endoplasmic reticulum Ca2+ ATPase 2a), which may be mediated by an activated endothelin (ET) system the myocardium. The aim study was test whether attenuation can achieved a novel dual receptor antagonist, CPU0213, association with up-regulation rats. shock produced faeces leak...

Our prophase studies have manifested that the sweet triterpenoid glycoside from leaves of Cyclocarya paliurus (CPST) effectively improved disorders glucolipid metabolism in vitro and patients. The current purpose was to further detect its mechanisms involved. results demonstrated CPST could ameliorate high-fat diet (HFD)-induced insulin resistance (IR), which linked reducing HFD-induced mice's body weight, serum glucose (GLUO), triglyceride (TG), total cholesterol (T-CHO) low-density...