A5025847114- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- HIV/AIDS drug development and treatment
- Quinazolinone synthesis and applications
- HIV/AIDS Research and Interventions
- Synthesis and Characterization of Heterocyclic Compounds
- Signaling Pathways in Disease
- Antibiotic Use and Resistance
- Recommender Systems and Techniques
- Pharmacological Effects of Natural Compounds
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Biometric Identification and Security
- Data Mining Algorithms and Applications
- Genetic and Environmental Crop Studies
- Reproductive Health and Technologies
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Agricultural pest management studies
- Genetics and Plant Breeding
- RNA Interference and Gene Delivery
- Pharmaceutical Quality and Counterfeiting
- Customer churn and segmentation
Symbiosis International University
2022-2024
Meharry Medical College
2023-2024
University of Pittsburgh
2019-2023
Indraprastha Institute of Information Technology Delhi
2023
Indian Institute of Technology Delhi
2023
Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalaya
2022
Jawaharlal Nehru Medical College
2019
Central Drug Research Institute
2010-2017
Academy of Scientific and Innovative Research
2014
ABSTRACT Cyclophilin A (CypA) binds to the HIV-1 capsid facilitate reverse transcription and nuclear entry counter antiviral activity of TRIM5α. Interestingly, recent studies suggest that enters nucleus an infected cell uncoats prior integration. We have previously reported protein regulates Therefore, we probed whether CypA-capsid interaction also this post-nuclear step. First, challenged CypA-expressing (CypA +/+ ) CypA-depleted -/- cells with quantified levels provirus. CypA-depletion...
Through the promotion of phagolysosome formation, autophagy has emerged as a crucial mechanism to eradicate intracellular Mycobacterium tuberculosis (Mtb). A cell-autonomous host defense called lysosome biogenesis and transports cytoplasmic cargos bacterial phagosomes lysosomes for destruction during infection. Similar occurrences occurred in stressful or starvation circumstances led autophagy, which is harmful cell. It interesting note that under both hunger infection states, transcription...
A series of dispiro-cycloalkanones were synthesized using the "Corey Chaykovsky" reaction α,α′-(E,E)-bis(benzylidene)-cycloalkanones/methanone in good yields. The compounds evaluated for their vitro antituberculosis activity against M. tuberculosis H37Rv and screened silico. Some selected mycobacterial NAD+-dependent DNA ligase inhibitory activity. Two showed antitubercular along with correlation to silico results.
Preclinical evaluation of drug-like molecules requires their oral administration to experimental animals using suitable vehicles. We studied the effect dosing with corn oil, carboxymethyl cellulose, dimethyl sulfoxide, and polysorbate-80 on progression Mycobacterium tuberculosis infection in mice. Infection was monitored by physical (survival time body weight) bacteriological (viable counts lungs) parameters. Compared water, oil significantly improved both sets parameters, whereas other...
The Personalized Job Recommender System is a subset of the custom recommendation system that provides solution to problem information overload and widely applied in numerous domains solve plethora problems, such as unemployment employment churn we have seen emerging at higher rates COVID era. Furthermore, different jobs require divergent skill sets from their candidates get hired. In this paper, analyze similarity techniques for Recommendation Systems based on research done field...
The V179I substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is selected humans or mouse models treated with certain nonnucleoside inhibitors (NNRTIs). While it often observed together other NNRTI resistance mutations, does not confer drug resistance. To understand how arises during treatment, we characterized HIV-1 molecular clones without the mutations Y181C Y181V. alone did to any NNRTIs tested, when present Y181C/V enhanced some by 3- 8-fold. In...
Integrating biometrics with Internet of Things (IoT) technology offers a potential method to strengthen smart transportation system security and verification processes. In this research, we investigate the possibility using convolutional neural network (CNN) enabled by IoT for more secure authentication identification people services. With help sensors devices spread across networks, it is possible gather biometric data in real time, allowing constant tracking analysis. The foundation CNN...
Innovative antibiotic resistance mitigation measures are needed to protect world health. This research examines how cloud-powered healthcare systems might improve management using predictive analytics. A strong prediction model for trends is created cloud-stored patient data and the Random Forest algorithm. The analyzes relevant aspects varied clinical demographic information. study uses a cloud-based infrastructure scale access information consumption trends. Forest's ensemble learning...
Abstract Cyclophilin A (CypA) promotes HIV-1 infection by facilitating reverse transcription, nuclear entry and countering the antiviral activity of TRIM5α. These multifunctional roles CypA are driven its binding to viral capsid. Interestingly, recent studies suggest that capsid lattice enters nucleus an infected cell uncoats just before integration. Therefore, we tested whether CypA-capsid interaction regulates post-nuclear steps infection, particularly First, challenged CypA-expressing...
Background: In pregnancy amniotic fluid surrounds the foetus and plays an important role in development of fetus. From very beginning formation extracoelomic cavity can be detected. To evaluate predictive value index (AFI) (<5) for adverse perinatal outcome terms cesarean section fetal distress, birth weight, meconium staining, Apgar scores, NICU admission at birth.Methods: This was a prospective study 100 antenatal women visited RMC, Ajmer, Rajasthan, India during year 2018 with...
Two mutations, G112D and M230I, were selected in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) by a novel nonnucleoside inhibitor (NNRTI). is located near HIV-1 polymerase active site; M230I hydrophobic region where NNRTIs bind. Thus, could directly interfere with NNRTI binding but not. Biochemical virological assays performed to analyze effects these mutations individually combination. alone caused reduction susceptibility NNRTIs, while did The G112D/M230I...
Background: Preclinical therapeutic efficacy of new anti-TB molecules is normally assessed by examining reduction in the bacterial load different organs mice infected with M. tuberculosis. However, since infection peripheral blood can mirror overall bacillary body, assessment bacteremia may reflect treatment outcome a more reliable manner while obviating need to examine organs. Keywords: tuberculosis, bacteremia, BALB/c mouse, drug efficacy, anti-tubercular drugs, bacteremia.
Privacy is an essential component of human existence, and now a fundamental right every individual. It realised that this to maintain one's secrecy solitude according whims requires definitive meaning strict practical application ensure citizens autonomy. The necessity for privacy regulations civil rights individual, regardless sexual choice, sparked the debate in twenty-first century. However, because not absolute right, invasion must be justified by law founded on legality, need,...
The experimentation was carried out for twenty-one diverse genotypes of pigeon pea eight quantitatively inherited traits. were grouped into six clusters following P.C. Mahalanobis D2 statistical techniques. cluster I consisted highest (16) and remaining five-clusters are solitary clusters. maximum intra-cluster distance observed I. greater inter-cluster recorded II VI while the lower values found III. contribution towards genetic diversity seed yield followed by 100-seed weight, secondary...