A5079058329- Sepsis Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Receptor Mechanisms and Signaling
- Lipoproteins and Cardiovascular Health
- Advanced Biosensing Techniques and Applications
- Plant Molecular Biology Research
- Chemokine receptors and signaling
- Nosocomial Infections in ICU
- Mass Spectrometry Techniques and Applications
- Global Maternal and Child Health
- Plant Reproductive Biology
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin K Research Studies
- Polysaccharides and Plant Cell Walls
- Neuropeptides and Animal Physiology
- Blood Coagulation and Thrombosis Mechanisms
- Monoclonal and Polyclonal Antibodies Research
Jena University Hospital
2023-2024
Institute of Molecular Biotechnology
2023-2024
Friedrich Schiller University Jena
2008-2024
Center for Clinical Studies
2023
Mediterranean Agronomic Institute of Chania
2021
Abstract G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed GRKs classified into cytosolic GRK2/3 membrane-tethered GRK5/6 subfamilies. interact with activated protein βγ-subunits to translocate the membrane. Yet, this need was not linked as a factor for bias, influencing effectiveness of β-arrestin-biased agonist creation. Using multiple approaches such mutants unable Gβγ, inhibitors...
Abstract The detachment of organs is controlled by highly regulated molecular mechanisms. position the tomato abscission zone (AZ) defined ratio proximal to distal part pedicel. In this study, was altered due a shift in AZ which attributed shorter and longer pedicels SlP4H3 RNAi OEX lines changes on cell division expansion part. This might be associated with LM2- JIM8-AGPs increased decreased throughout JIM13 AGPs were downregulated flower lines, pointing role regulation. addition, Co-IP...
Abstract Chemokine stimulation of atypical chemokine receptor 3 (ACKR3) does not activate G proteins but recruits arrestins. It is a scavenger that indirectly influences responses by restricting the availability CXCL12, an agonist shared with canonical CXCR4. ACKR3 upregulated in numerous disorders. Due to limited insights chemokine-activated signaling, it unclear how contributes pathological phenotypes. One explanation may be high constitutive activity drives non-canonical signaling through...
Summary G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. Recently, it was shown that GPCRs differentially depend on GRK2/3, GRK2/3/5/6 or GRK5/6 for their regulation. The four ubiquitously expressed GRKs classified into the cytosolic GRK2/3 membrane-tethered subfamily. In vitro studies revealed interact with membrane-localized protein βγ-subunits. Yet, role of this interaction as crosslink between activation...