A5085345681- Adipose Tissue and Metabolism
- Sulfur Compounds in Biology
- Obstructive Sleep Apnea Research
- Cancer, Hypoxia, and Metabolism
- Air Quality and Health Impacts
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- Immune cells in cancer
- Gut microbiota and health
- Advanced Nanomaterials in Catalysis
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Nutritional Studies and Diet
- Muscle metabolism and nutrition
ETH Zurich
2021-2025
Board of the Swiss Federal Institutes of Technology
2021
Harvard University
2020
Dietary protein restriction (PR) has rapid effects on metabolism including improved glucose and lipid homeostasis, via multiple mechanisms. Here, we investigate responses of fecal microbiome, hepatic transcriptome, metabolome to six diets with from 18% 0% energy in mice. PR alters microbial composition, but metabolic are not transferable transplantation. Hepatic transcriptome significantly altered lower than 10% protein. Changes upon correlate calorie a larger magnitude specific changes...
Background Failure rates after revascularization surgery remain high, both in vein grafts (VG) and arterial interventions. One promising approach to improve outcomes is endogenous upregulation of the gaseous transmitter-molecule hydrogen sulfide, via short-term dietary restriction. However, strict patient compliance stands as a potential translational barrier vascular population. Here we present new therapeutic approach, locally applicable gel containing sulfide releasing prodrug (GYY),...
Objective: Hydrogen sulfide (H2S) is a gaseous signaling molecule and redox factor important for cardiovascular function. Deficiencies in its production or bioavailability are implicated atherosclerotic disease. However, it unknown if circulating H2S levels differ between vasculopaths healthy individuals, so, whether measurements can be used to predict surgical outcomes. Here, we examined: (1) Plasma patients undergoing vascular surgery compared these controls, (2) the association mortality...
Summary Dietary restriction of the sulfur-containing amino acids methionine and cysteine (SAAR) improves body composition, enhances insulin sensitivity, extends lifespan; benefits seen also with endurance exercise. Yet, impact SAAR on skeletal muscle remains largely unexplored. Here we demonstrate that one week in sedentary, young, male mice increases exercise capacity. Indirect calorimetry showed increased lipid oxidation at rest delayed onset carbohydrate utilization during Transcriptomic...
ABSTRACT Objective Hydrogen sulfide (H 2 S) is a gaseous signaling molecule and redox factor important for cardiovascular function. Deficiencies in its production or bioavailability are implicated atherosclerotic disease. However, it unknown if circulating H S levels differ between vasculopaths healthy individuals, so, whether measurements can be used to predict surgical outcomes. Here, we examine: 1) Plasma patients undergoing vascular surgery compare these controls, 2) Associations...