A5103256119- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Diabetes Management and Research
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Genetic Syndromes and Imprinting
- Bone health and treatments
- Cancer, Hypoxia, and Metabolism
- Nutrition, Health and Food Behavior
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Vitamin D Research Studies
- Adrenal Hormones and Disorders
- Diabetes Treatment and Management
- Peroxisome Proliferator-Activated Receptors
- Parathyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Retinal Diseases and Treatments
- Genetic and Kidney Cyst Diseases
Seoul National University
2011-2022
Seoul National University Hospital
2001-2017
Changwon National University
2017
Gyeongsang National University
2017
New Generation University College
2001-2015
Clinical Research Institute
2001-2006
To assess the changes in bone mineral density and osteoblastic activity patients with hyperthyrodism to investigate relationship between those changes, we measured serum osteocalcin 109 Graves' disease, comprising 75 untreated 34 under treatment, 200 normal controls. The degree of change was quantified Z transformation, which used means SDs densities obtained process age- sex-matched 1:1 pairing developed by ourselves. Bone low female hyperthyroidism spine, femur neck, trochanter, Ward's...
Recently, the European Society of Endocrinology (ESE), in collaboration with Network for Study Adrenal Tumors (ENSAT), asserted that adrenal incidentalomas (AIs) <4 cm and ≤10 Hounsfield units (HU) do not require further follow-up imaging. To validate clinical application strategies suggested by 2016 ESE-ENSAT guidelines, we explored characteristics natural course AIs a single center over 13 years.This retrospective cohort study included total 1149 patients diagnosed between 2000 2013...
Objectives Recently, somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D genes were found to be associated with the pathogenesis of aldosterone-producing adenoma (APA). This study aimed investigate prevalence examine correlations between these clinical biochemical characteristics Korean patients APA. Methods We performed targeted gene sequencing 66 APA detect genes. Results Somatic KCNJ5 47 (71.2%) (31 cases p.G151R 16 p.L168R); two mutually exclusive. not observed. more prevalent female...
Abdominal fat accumulation is known to be strongly implicated in development of metabolic syndrome (MetS).We examined diagnostic values obesity-related parameters 95 men and 185 women, we determined optimal cutoff visceral area (VFA) waist circumference (WC) for predicting the presence multiple non-adipose components MetS.Receiver operating characteristic (ROC) curve analysis revealed that VFA was best indicator MetS.WC exhibited similar postmenopausal whereas WC inferior premenopausal women...
It was previously reported in Korea that there were 1.4 case per million year of acromegaly. This low comparison with the extrapolated values Western European countries. We expected incidence acromegaly would be much higher now because recently improved medical facilities, diagnostic tools and coverage insurance to all population South Korea.The purpose this nationwide survey examine prevalence patients acromegaly, mode treatment outcome surgical recent 5 years.We requested collected records...
Umbilical cord blood (UCB) has recently been recognized as a new source of mesenchymal stem cells (MSCs) for use in cell therapy. We studied the effects systemic injection human UCB-MSCs and their conditioned medium (CM) on ovariectomy (OVX)-induced bone loss nude mice. Ten-week-old female mice were divided into six groups: Sham-operated treated with vehicle (Sham-Vehicle), OVX subjected to (OVX-MSC), or dermal fibroblast (OVX-DFB) transplantation, UCB-MSC CM (OVX-CM), zoledronate (OVX-Zol),...
Biochemical markers of bone turnover have been suggested to be useful in monitoring the efficacy antiresorptive therapy. In this study, we investigated predictive value determine short-term response mineral density (BMD) and identify nonresponders 138 postmenopausal women (mean age 58 years) with osteoporosis given either hormone thearpy (HT) or alendronate. Urinary type I collagen N-telopeptide (NTx) serum osteocalcin (OC) at baseline, 3, 6 months after treatment as well spine femoral neck...
Osteoporosis is a common disease that affects the majority of older women and men.The pathophysioloy osteoporosis involves broad spectrum endogenous
Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD). Genetic susceptibility plays an important role in development and progression diabetic nephropathy. Previous studies have revealed that polymorphisms SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute 3, might contribute to genetic essential hypertension. In this study, we examined whether gene locus associated with ESRD resulting from We genotyped 11 single nucleotide...
Patients with aldosterone-producing adenomas are treated using surgery, and patients idiopathic hyperaldosteronism receive medical treatment mineralocorticoid receptor antagonists (MRAs). However, the outcomes of surgical for primary aldosteronism (PA) remain unclear. Therefore, we compared PA aimed to identify a specific subgroup that might benefit from treatment. We identified 269 who were (unilateral excess: 221 cases; bilateral 48 cases) during 2000-2015 at Seoul National University...
We report here the cases of two females with Graves' disease who developed insulin autoimmune syndrome after treatment methimazole. The patients exhibited a sudden altered mental state methimazole for approximately 4 weeks. Patients had hypoglycemia serum glucose below 70 mg/dL, and laboratory findings showed both high levels titers autoantibodies. women never been exposed to or oral antidiabetic agents, there was no evidence insulinoma in imaging studies. After loading, glucose, total...