A5071828241- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Sleep and related disorders
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Restless Legs Syndrome Research
- Transcranial Magnetic Stimulation Studies
- Obstructive Sleep Apnea Research
- Hemoglobinopathies and Related Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Metabolism and Genetic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Mitochondrial Function and Pathology
- Sleep and Work-Related Fatigue
- Advanced Memory and Neural Computing
- Hereditary Neurological Disorders
Ewha Womans University
2015-2025
Ewha Womans University Medical Center
2015-2024
Dongwha Pharm (South Korea)
2013-2024
University of California, Berkeley
2023
Neurology, Inc
2012-2021
Convergence
2021
Max Planck Institute of Psychiatry
2020
Asan Medical Center
2020
Baewha Women's University
2019
Kyung Hee University
2017
In this paper, we present a vibration energy harvester using magnetoelectric laminate composite and springless spherical permanent magnet as proof mass. The utilizes freely movable to transform external into time varying magnetic field applied the transducer. consists of Ni–Mn–Ga-based MSMA (magnetic shape memory alloy) element PZT (lead zirconate titanate) plate. A proof-of-concept has been fabricated characterized at various input accelerations frequencies. maximum open circuit voltage...
Objective: The purpose of this study was to investigate functional connectivity (FC) changes in epileptogenic networks intractable partial epilepsy obtained from resting-state fMRI by using intrinsic contrast (ICC), a voxel-based network measure degree that reflects the number connections each voxel. Methods: We measured differences between intrahemispheric- and interhemispheric-ICC (ICC intra−inter ) could reveal localized abnormalities zones while more global would be eliminated when...
Purpose: To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy. Methods: Thirty-six long-term (at least 1 year) monotherapy were compared 36 taking carbamazepine, 32 valproate, age- sex-matched controls. Subjects completed mineral density (BMD) studies. Serum was analyzed for indices metabolism. Key Findings: BMD Z-scores, serum 25-hydroxyvitamin D 1alpha,25-dihydroxyvitamin D3 concentrations did not differ among groups. calcium...
The number of patients suffering post-stroke seizure after ischemic stroke (PSSi) is quite considerable, especially because more prevalent than hemorrhage in the general population. This study aimed to determine predicting factors for recurrence survivors and develop a clinical scoring system prediction risks first PSSi.We reviewed 3792 who had admitted Ewha Womans University hospital between 2001 2012. A total 124 (3.3 %) experienced PSSi were recruited (mean follow-up 44.4 months). Medical...
Transcranial focused ultrasound (tFUS) is a promising technique of non-invasive brain stimulation for modulating neuronal activity with high spatial specificity. The medial prefrontal cortex (mPFC) has been proposed as potential target neuromodulation to prove emotional and sleep qualities. We aim set up an appropriate clinical protocol investigating the effects tFUS bilateral mPFC function brain-wide network using different sonication parameters. Seven participants received 20 min 250 kHz...
Summary: Purpose: Women with epilepsy (WWE) tend to have hormonal and metabolic abnormalities, raising concerns about an increased risk of cardiovascular disorders. This study was performed determine whether itself and/or antiepileptic drug (AED) medication cause abnormalities. Methods: WWE in premenopausal state aged 18 45 years old, currently on AED monotherapy for more than six months, were recruited this study. The subjects checked their oral temperature each morning, tested serum levels...
Patterns of responses in the cerebral cortex can vary, and are influenced by pre-existing cortical function, but it is not known how rapidly these variations occur humans. We investigated response patterns to electrical stimulation vary intact human brain. also whether type functional change occurring at a given location with would help predict distribution elsewhere over that location. did this studying afterdischarges following awake humans undergoing evaluations for brain surgery....
Summary Purpose: Impaired consciousness in epileptic seizures has a major negative impact on patient quality of life. Prior work unconsciousness mainly used retrospective and nonstandardized methods. Our goal was to validate obtain initial data using standardized prospective testing battery. Methods: The responsiveness epilepsy scale (RES) 52 patients during continuous video–electroencephalography (EEG) monitoring. RES begins with higher‐level questions commands, switches adaptively more...
Automatic sleep staging based on deep learning (DL) has been attracting attention for analyzing quality and determining treatment effects. It is challenging to acquire long-term data from numerous subjects manually labeling them even though most DL-based models are trained using large-scale provide state-of-the-art performance. One way overcome this shortage create a pre-trained network with an existing dataset (source domain) that applicable small cohorts of datasets (target domain);...
Abstract Diversity, equity, and inclusivity (DEI) are important for scientific innovation progress. This widespread recognition has resulted in numerous initiatives enhancing DEI recent years. Although progress been made to address gender racial disparities, there remain biases that limit the opportunities historically under-represented researchers succeed academia. As members of Organization Human Brain Mapping (OHBM) Diversity Inclusivity Committee (DIC), we identified most challenging...
Individual differences in sleep duration have been reported, and genetic components of identified showing various heritability. To identify variants that contribute to duration, we conducted a human genome-wide identification on performed confirmatory experiments using Drosophila model. Genome-wide association study was analyzed determine the with self-aware from two community-based cohort, Ansan (cohort 1, n = 4635) Ansung 2, 4205), recruited Korean Genome Epidemiology Study. single...
A 22 year-old woman suffered from recurrent episodes of hypersomnia, apathy, and hyperphagia. The symptoms occurred 3 to 4 times per year, each attack lasted 2 weeks. 99mTc-ethylcysteinate dimer brain single photon emission computed tomography (SPECT) was performed during symptomatic asymptomatic periods. To localize regions with perfusion changes period, SPECT subtracted SPECT. showed significant hypoperfusion in the left hypothalamus, bilateral thalami, basal ganglia, medial dorsolateral...
Cortical physiology in human motor cortex is influenced by behavioral training (MT) as well repetitive transcranial magnetic stimulation protocol such intermittent theta burst (iTBS). This study aimed to test whether MT and iTBS can interact with each other produce additive changes cortical physiology. We hypothesized that potential interaction between would be dependent on BDNF Val66Met polymorphism, which known affect neuroplasticity the cortex. Eighty two healthy volunteers were genotyped...
Complications Resulting from Non-Oral Occupational Methanol PoisoningMethanol poisoning results in neurological complications including visual disturbances, bilateral putaminal hemorrhagic necrosis, parkinsonism, cerebral edema, coma, or seizures.Almost all reported cases of methanol are caused by oral ingestion methanol.However, recently there was an outbreak via non-oral exposure that resulted severe to a few workers at industrial sites Korea.We present 3 patients who had resulting...
To investigative whether radiomics features in bilateral hippocampi from MRI can identify temporal lobe epilepsy (TLE). A total of 131 subjects with (66 TLE patients [35 right and 31 left TLE] 65 healthy controls [HC]) were allocated to training (n = 90) test 41) sets. Radiomics 186) the extracted T1-weighted images. After feature selection, machine learning models trained. The performance classifier was validated set differentiate HC ipsilateral HC. Identical processes performed (training...
Treatment for epilepsy primarily involves antiseizure medications (ASMs), which can be characterized using the clinical data warehouse (CDW) database. In this study, we compared retention rates and time to successful treatment various ASMs reflect both efficacy adverse effects in patients with newly diagnosed epilepsy.
Diversity, equity, and inclusivity (DEI) are important for scientific innovation progress. This widespread recognition has resulted in numerous initiatives enhancing DEI recent years. Although progress been made to address gender racial disparities, there remains be biases that limit the opportunities historically underrepresented individuals succeed academia. As members of Organization Human Brain Mapping (OHBM) Diversity Inclusivity committee (DIC), we identified most challenging imminent...
Here, we report the structural evidence of cerebral white matter abnormalities in Charcot‐Marie‐Tooth (CMT) patients and relationship between these clinical disability. Brain diffusion tensor imaging (DTI) was performed CMT with demyelinating (CMT1A/CMT1E), axonal (CMT2A/CMT2E), or intermediate (CMTX1/DI‐CMT) peripheral neuropathy. Although all had normal brain magnetic resonance imaging, genetic subgroups except CMT1A abnormal DTI findings indicative significant abnormalities: decreased...
Study Objectives: The sleep patterns of humans are greatly influenced by age and sex have various effects on overall health as they change continuously during the lifespan.We investigated age-dependent changes in properties their relation to middle-aged individuals.Methods: We analyzed data from 2,640 participants (mean 49.8 ± 6.8 years at baseline, 50.6% women) Korean Genome Epidemiology Study, which assessed habits using Pittsburgh Sleep Quality Index other clinical characteristics.We...
Abstract Study Objectives Evidence suggests that sleep–wake cycle disruption could be an early manifestation of neurodegeneration and might even a risk factor for developing diseases in healthy adults. We investigated the impact circadian phase change on structural functional brain deterioration late-adulthood population. Methods analyzed data 1874 participants (mean age 58.6 ± 6.3 years, 50.3% female) from Korean Genome Epidemiology Study, who were identified as cognitively unimpaired. The...