A5045580064- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Nutrition and Health in Aging
- Traditional Chinese Medicine Studies
- Technology Use by Older Adults
- Esophageal Cancer Research and Treatment
- Healthcare and Venom Research
- Genetic Associations and Epidemiology
- Health disparities and outcomes
- Esophageal and GI Pathology
- Diverse Approaches in Healthcare and Education Studies
- Liver Disease and Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Multi-Criteria Decision Making
- Frailty in Older Adults
- Renin-Angiotensin System Studies
- Pharmacological Effects and Toxicity Studies
- Radiation Dose and Imaging
- Dementia and Cognitive Impairment Research
- Helicobacter pylori-related gastroenterology studies
- Epilepsy research and treatment
Duke University
2024
Yonsei University
2014-2023
Seoul National University Hospital
2023
DePaul University
2022
Hallym University
2010-2019
Kangdong Sacred Heart Hospital
2019
Severance Hospital
2012-2017
Swedish Civil Contingencies Agency
2017
Yonsei University Health System
2013
Seoul National University
2006-2012
Sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD). This study investigated whether sarcopenia significant fibrosis in subjects NAFLD. Data from the Korean National Health and Nutrition Examination Surveys 2008‐2011 database were analyzed. NALFD was defined by NAFLD fat score, comprehensive or hepatic steatosis index. Degree of assessed score (NFS), FIB‐4, Forns Significant as FIB‐4 ≥2.67 highest quartile values NFS index (= total appendicular skeletal muscle mass...
Computed tomography (CT) has become the predominant test for diagnosing acute appendicitis in adults. In children and young adults, exposure to CT radiation is of particular concern. We evaluated rate negative (unnecessary) appendectomy after low-dose versus standard-dose abdominal adults with suspected appendicitis.In this single-institution, single-blind, noninferiority trial, we randomly assigned 891 patients either (444 patients) or (447 patients). The median dose terms dose-length...
Early detection of liver cirrhosis in its subclinical stage is paramount importance to identify high‐risk individuals for developing hepatocellular carcinoma (HCC). This study investigated whether transient elastography (TE) can patients with (SCC) who are at increased risk HCC among chronic hepatitis B (CHB) without clinical evidence cirrhosis. A total 2,876 CHB received TE examinations between April 2006 and December 2012 were enrolled this prospective study. SCC was defined as a...
Several risk prediction models have been created to predict hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) occurrence, with promising results. However, their prognostic performances need be validated in the era of antiviral therapy. From 2006 2011, patients chronic HBV infection were recruited and those a history HCC or hepatic decompensation excluded. At enrollment, liver stiffness (LS) was measured using transient elastography. We assessed conventional (CU-HCC, GAG-HCC,...
This study aimed to enhance the diagnostic accuracy by defining different cutoff liver stiffness measurement (LSM) values according alanine aminotransferase (ALT) level and combining LSM with noninvasive models in patients chronic hepatitis B (CHB).Several studies have indicated that ALT influences using FibroScan.The prospectively enrolled 200 (143 men, mean age 45.4 y) between June 2007 November 2008 who had been diagnosed CHB underwent both biopsy on same day.The area under receiver...
To identify risk factors for postgastrectomy vitamin B12 deficiency and the time course of its development.Postgastrectomy worsens quality life gastric cancer survivors, B12-related neuropathy is irreversible if recognized late. However, clinical pattern development after gastrectomy remains unclear.We reviewed 645 patients with who underwent distal subtotal (DG; n = 469) or total (TG, 176) between 2003 2010. Univariate multivariate analyses were performed to deficiency.Cumulative rates 100%...
Purpose: To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy. Methods: Thirty-six long-term (at least 1 year) monotherapy were compared 36 taking carbamazepine, 32 valproate, age- sex-matched controls. Subjects completed mineral density (BMD) studies. Serum was analyzed for indices metabolism. Key Findings: BMD Z-scores, serum 25-hydroxyvitamin D 1alpha,25-dihydroxyvitamin D3 concentrations did not differ among groups. calcium...
Abstract Purpose: To evaluate the effect of diffusion‐weighted imaging (DWI) methods, apparent diffusion coefficient (ADC) calculation and selection b‐values on ADCs measurement reproducibility malignant hepatic tumors. Materials Methods: Nineteen patients with pathologically confirmed tumors underwent breath‐hold DWI (b‐values = 0, 50, 500 s/mm 2 ) respiratory‐triggered (0, 300, 500, 1000 twice a 1.5 T magnetic resonance (MRI) scanner. were calculated using two b‐value and/or multiple...
To compare low and standard radiation doses in intravenous contrast material-enhanced abdominal computed tomography (CT) for the diagnosis of acute appendicitis young adults.The institutional review board approved this retrospective study waived informed consent. The included 257 patients (age range, 15-40 years) who underwent CT suspected performed by using a dose (n = 125) or 132). Receiver operating characteristic (ROC) analysis, Fisher exact tests, Mann-Whitney U tests were used to...
Abstract Background Cognitive frailty, a condition characterized by physical frailty with cognitive impairment, is emerging as determinant of adverse health outcomes in older adults. However, its prevalence and correlation associated factors are unknown the aging population Korea. Objectives To estimate identify it among Korean Methods A secondary analysis was performed using Longitudinal Study Aging seventh survey dataset collected 2018. Multinomial logistic regression analyses were...
The aim of this study was to identify the characteristic symptoms which can be used for diagnosis hwa-byung, a culture-related anger syndrome in Korea.The Hwa-byung Scale were correlated with Korean versions Hamilton Depression Rating (K-HDRS) and State Trait Anger Inventory (K-STAXI) 89 patients, who diagnosed as having major depressive disorder, dysthymic anxiety disorders, somatoform or adjustment disorder according Diagnostic Statistical Manual Mental Disorders, fourth edition (DSM-IV)...
Abstract Background TILs have been reported to be a prognostic factor in human cancers. We assessed the significance of tumor‐infiltrating regulatory T cells gastric cardia cancer. Methods retrospectively reviewed database Severance Hospital for patients who underwent curative resection cancer from Jan 2000 Dec 2006 and identified 180 patients. Immunohistochemistry TIL subsets was performed against CD3, CD4, CD8, Foxp3, granzyme B resected tumor specimens. The absolute numbers relative...
The purpose of this study was to develop and validate a novel transient elastography-based predictive model for occurrence hepatocellular carcinoma (HCC).A total 1,250 patients with chronic hepatitis B baseline liver stiffness values were recruited between May 2005 December 2007. HCC constructed based on Cox proportional hazards model. We estimated disease-free probabilities at 3 years. Discrimination calibration used the model.HCC occurred in 56 during median follow-up 30.7 months....
The prognoses of gastric cancer patients vary greatly among countries. Meanwhile, tumor-node-metastasis (TNM) staging system shows limited accuracy in predicting patient-specific survival for cancer. objective this study was to create a simple, yet universally applicable prediction model surgically treated patients.A 5-year overall regardless curability developed using test data set 11,851 consecutive patients.The model's coefficients were selected based on univariate and multivariate...
Gamma-glutamyl transpeptidase-to-platelet ratio (GPR) can evaluate the degree of liver fibrosis. We investigated whether GPR predict development hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients.We retrospectively evaluated 1109 CHB patients that were enrolled between 2006 and 2012, all had available data for assessment at enrollment. Three risk groups defined according to tertile stratification: < 0.05, low-risk (n = 370 [33.4%]); 0.05-0.24, intermediate-risk > 0.24,...
The need for digital literacy in aging populations is increasing the digitalizing society. Digital involves identification, evaluation, and communication of information through various devices or relevant programs.
Background/Aims Single-nucleotide polymorphisms (SNPs) near the interleukin 28B gene (IL28B; interferon [IFN]-λ-3) are associated with outcomes of chronic hepatitis C virus (HCV) and B (HBV) infection treated peginterferon (PEG-IFN) alpha-based antiviral therapy. In this study, we investigated influence IL28B on spontaneous clearance HBV in a large Korean cohort. Methods Between January 2007 June 2010, total 208 patients newly diagnosed HBV-related hepatocellular carcinoma were recruited as...