A5062524423- Astrophysics and Star Formation Studies
- Stellar, planetary, and galactic studies
- Astro and Planetary Science
- Plant-Microbe Interactions and Immunity
- Solar and Space Plasma Dynamics
- Lipid Membrane Structure and Behavior
- Fungal Infections and Studies
- Photoreceptor and optogenetics research
- Genetic Neurodegenerative Diseases
- RNA modifications and cancer
- Atmospheric Ozone and Climate
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Antifungal resistance and susceptibility
- Cancer-related gene regulation
- Chemical Reactions and Isotopes
- Neuroinflammation and Neurodegeneration Mechanisms
- Fungal and yeast genetics research
- Crystallization and Solubility Studies
- Plant Pathogens and Fungal Diseases
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Toxin Mechanisms and Immunotoxins
- Astrophysical Phenomena and Observations
- Neurological disorders and treatments
Kyung Hee University
2025
Massachusetts Institute of Technology
2018-2024
Ulsan National Institute of Science and Technology
2022-2024
Korea Astronomy and Space Science Institute
2019-2023
Chungnam National University
2016-2023
National Institutes of Health
2005-2023
National Center for Biotechnology Information
2023
Seoul National University Hospital
2022-2023
Hanyang University Guri Hospital
2023
Broad Institute
2020-2022
The Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/) is an international public repository for high-throughput microarray and next-generation sequence functional genomic data sets submitted by the research community. resource supports archiving of raw data, processed metadata which are indexed, cross-linked searchable. All freely available download in a variety formats. GEO also provides several web-based tools strategies to assist users query, analyse visualize data. This...
Cryptococcus neoformans is a haploid environmental organism and the major cause of fungal meningoencephalitis in AIDS patients. Fluconazole (FLC), triazole, widely used for maintenance therapy cryptococcosis. Heteroresistance to FLC, an adaptive mode azole resistance, was associated with FLC failure cases but mechanism underlying resistance unknown. We comparative genome hybridization quantitative real-time PCR order show that C. adapts high concentrations by duplication multiple...
Arabidopsis LEAFY COTYLEDON1 (LEC1) is a critical regulator required for normal development during the early and late phases of embryogenesis that sufficient to induce embryonic in vegetative cells. LEC1 encodes HAP3 subunit CCAAT binding transcription factor. We show 10 (AHAP3) subunits can be divided into two classes based on sequence identity their central, conserved B domain. its most closely related subunit, LEC1-LIKE (L1L), constitute LEC1-type AHAP3 subunits, whereas remaining are...
Abstract The Gene Expression Omnibus (GEO) is an international public repository that archives gene expression and epigenomics data sets generated by next-generation sequencing microarray technologies. Data are typically submitted to GEO researchers in compliance with widespread journal funder mandates make publicly accessible. resource handles raw files, processed files descriptive metadata for over 200 000 studies 6.5 million samples, all of which indexed, searchable downloadable....
Post-transcriptional regulators have emerged as robust effectors of metastasis and display deregulated expression through unknown mechanisms. Here, we reveal that the human microRNA-335 locus undergoes genetic deletion epigenetic promoter hypermethylation in every metastatic derivative obtained from independent patients’ malignant cell populations. Genetic miR-335 is a common event breast cancer, enriched for cancer metastases, also correlates with ovarian recurrence. We furthermore identify...
Summary Cryptococcus neoformans is an environmental pathogen requiring atmospheric levels of oxygen for optimal growth. Upon inhalation, C. disseminates to the brain and causes meningoencephalitis, but mechanisms by which adapts low‐oxygen environment in have not been investigated. We found that SRE1 , a homologue mammalian sterol regulatory element‐binding protein (SREBP), functions oxygen‐sensing pathway. Low decreased synthesis triggered activation membrane‐bound Sre1p cleavage‐activating...
LEAFY COTYLEDON1 (LEC1) is a central regulator that required for many aspects of Arabidopsis embryogenesis and sufficient to induce embryo development in vegetative cells when expressed ectopically. We previously showed LEC1 encodes an HAP3 subunit the CCAAT binding factor 10 (AHAP3) subunits can be divided into two classes, LEC1-type non-LEC1-type, based on sequence similarity within their B domains. By analyzing ability chimeric containing different combinations domains from non-LEC1-type...
Abstract Striatal projection neurons (SPNs), which progressively degenerate in human patients with Huntington’s disease (HD), are classified along two axes: the canonical direct-indirect pathway division and striosome-matrix compartmentation. It is well established that indirect-pathway SPNs susceptible to neurodegeneration transcriptomic disturbances, but less known about how axis compromised HD relation axis. Here we show, using single-nucleus RNA-sequencing data from male Grade 1 patient...
Strains of the yeast Saccharomyces cerevisiae differ in their sensitivities to tobacco osmotin, an antifungal protein PR-5 family. However, cells sensitive osmotin showed resistance osmotin-like proteins purified from plant Atriplex nummularia, indicating a strict specificity between and its target cell. A member gene family encoding stress induced by heat nitrogen limitation, collectively called Pir proteins, was isolated among genes that conveyed susceptible strain. We show overexpression...
Highlights•Isolated 3′ UTRs accumulate in aging D1 spiny projection neurons of mouse striatum•3′ UTR RNAs occur with oxidative stress and can be induced by ROS-inducing drugs•3′ are associated the human brain short peptide production•Isolated may result from impaired ABCE1 deficient ribosome recyclingSummaryParticular regions cell populations exhibit increased susceptibility to aging-related stresses. Here, we describe age-specific brain-region-specific accumulation ribosome-associated that...
The developmental transcription factor SOX4 contributes to the metastatic spread of multiple solid cancer types, but its direct target genes that mediate progression are not well defined. Using a systematic molecular and genomic approach, we identified TMEM2 transmembrane protein gene as transcriptional SOX4. was transcriptionally activated by in breast cells where, like SOX4, found proinvasive promigratory effects. Similarly, sufficient promote colonization expression primary tumors...
Abstract Dust polarization induced by aligned grains is widely used to study magnetic fields in various astrophysical environments. However, the question of what optical depth grain alignment still exists a dense molecular cloud (MC) unclear. In this paper, we derive analytical formulae for minimum size ( align ) and rotational disruption disr RAdiative Torques (RATs) as function local physical parameters within MCs. We first find approximations radiation strength mean wavelength attenuated...
Abstract The heart of the Large Magellanic Cloud, 30 Doradus, is a complex region with clear core-halo structure. Feedback from stellar cluster R136 has been shown to be main source energy creating multiple parsec-scale expanding-shells in outer region, and carving nebula core proximity ionization source. We present morphology strength magnetic fields ( B -fields) Doradus inferred far-infrared polarimetric observations by SOFIA/HAWC+ at 89, 154, 214 μ m. -field complex, showing bending...
Osmotin is a plant PR-5 protein. It has broad spectrum of antifungal activity, yet also exhibits specificity for certain fungal targets. The structural bases this remain unknown. We show here that full sensitivity Saccharomyces cerevisiae cells to the protein osmotin dependent on function MNN2, MNN4 and MNN6. MNN2 an alpha-1, 2-mannosyltransferase catalyzing addition first mannose branches poly l,6-mannose backbone outer chain cell wall N-linked mannans. MNN6 are required transfer...
Summary Cryptococcus neoformans is a pathogenic yeast that causes life‐threatening meningoencephalitis and grows well on mycological media regardless of inoculum size. Interestingly, deletion the global repressor TUP1 in C. uncovered density‐dependent growth phenotype reminiscent quorum‐sensing phenomenon. An size lower than 10 3 cells tup1 Δ strain failed to form colonies agar while inocula 5 −10 6 per plate formed lawn. This phenotype, expressed as inability grow at low cell densities, was...