A5033286958- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Garlic and Onion Studies
- Eicosanoids and Hypertension Pharmacology
- Computational Drug Discovery Methods
- Bone Metabolism and Diseases
- Nitric Oxide and Endothelin Effects
- Metabolism, Diabetes, and Cancer
- Synthesis and biological activity
- NF-κB Signaling Pathways
- Phytoestrogen effects and research
- Cancer-related Molecular Pathways
- Adenosine and Purinergic Signaling
- Bioactive Compounds and Antitumor Agents
- Bone health and treatments
- Estrogen and related hormone effects
- Ginger and Zingiberaceae research
- Immune Response and Inflammation
- Cholinesterase and Neurodegenerative Diseases
- Synthesis of heterocyclic compounds
- Histone Deacetylase Inhibitors Research
- Synthesis and Catalytic Reactions
- Drug Transport and Resistance Mechanisms
- Quinazolinone synthesis and applications
- DNA and Nucleic Acid Chemistry
Sookmyung Women's University
2015-2024
Mayo Clinic in Florida
2024
Stanford University
1999
We identified four anti-inflammatory sulfur-containing compounds from garlic, and their chemical structures were as Z- E-ajoene oxidized sulfonyl derivatives of ajoene. The sulfur inhibited the production nitric oxide (NO) prostaglandin E(2) (PGE(2)) expression pro-inflammatory cytokines tumor necrosis factor-α, interleukin-1β, interleukin-6 in lipopolysaccharide (LPS)-activated macrophages. Western blotting reverse transcription-polymerase chain reaction analysis demonstrated that these...
Abstract The global pandemic crisis, coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has claimed lives of millions people across world. Development and testing anti-SARS-CoV-2 drugs or vaccines have not turned to be realistic within timeframe needed combat this pandemic. Here, we report a comprehensive computational approach identify multi-targeted drug molecules against SARS-CoV-2 proteins, whichare crucially involved in viral–host...
Hepatic steatosis, a hepatic component of metabolic syndrome, is common and may progress to steatohepatitis cirrhosis. The liver X receptor-α (LXRα)-sterol regulatory element binding protein-1c (SREBP-1c) pathway plays key role in steatosis. This study investigated the potential ajoene, stable garlic by-product, inhibit high fat diet (HFD)-induced steatosis underlying mechanism. Ajoene treatment attenuated accumulation induction lipogenic genes HFD-fed mice. Blood biochemical analyses...
Glioblastoma multiforme (GBM) is one of the most common brain malignancies and has a very poor prognosis. Recent evidence suggests that presence cancer stem cells (CSC) in GBM rare CSC subpopulation resistant to chemotherapy may be responsible for treatment failure unfavorable prognosis GBM. A garlic-derived compound, Z-ajoene, shown range biological activities, including anti-proliferative effects on several cancers. Here, we demonstrated first time Z-ajoene specifically inhibits growth...
Garlic has long been used as a folk medicine. Numerous studies have demonstrated that garlic extract and its sulfur-containing compounds inhibited nuclear factor kappa B (NF-κB) activation induced by various receptor agonists including lipopolysaccharide (LPS). Toll-like receptors (TLRs) play key role in sensing diverse microbial products inducing innate immune responses. The dimerization of TLR4 is required for the downstream signaling pathways, NF-κB. Therefore, may be one first lines...
Abstract A balance between bone formation and resorption is critical for the maintenance of mass. In many pathological conditions, including chronic inflammation, uncontrolled activation osteoclast differentiation often causes excessive that results in osteoporosis. this study, we identified osteopenia phenotype mice lacking Usp18 (also called Ubp43), which a deISGylating enzyme known as negative regulator type I IFN signaling. The expression was induced preosteoclasts upon receptor...
NF-κB has been implicated as a therapeutic target for the treatment of rheumatoid arthritis. We previously synthesized thiourea analogue, SPA0355, which suppressed activity. Here we have assessed anti-inflammatory and anti-arthritic effects SPA0355.We evaluated SPA0355 on human fibroblast-like synoviocytes in vitro collagen-induced arthritis (CIA) mice vivo.In experiments demonstrated that chemokine production, matrix metalloproteinase secretion cell proliferation induced by TNF-α...
A novel small molecule based on benzothiazole-piperazine has been identified as an effective multi-target-directed ligand (MTDL) against Alzheimer's disease (AD). Employing a medicinal chemistry approach, combined with molecular docking, MD simulation, and binding free energy estimation, compound 1 emerged potent MTDL AD. Notably, demonstrated efficient to both AChE Aβ1–42, involving crucial interactions within their active sites. It displayed (ΔGbind) −18.64± 0.16 −16.10 ± 0.18 kcal/mol...
Black berry ( Syzygium cumini ) fruit is useful in curing diabetic complications; however, its role diabetes‐induced cardiomyopathy not yet known. In this study, we investigated the regulation of gelatinase‐B (MMP‐9) by S. methanol seed extract (MSE) using real‐time PCR, RT‐PCR, immunocytochemistry, gel diffusion assay, and substrate zymography. The regulatory effects MSE on NF‐ κ B, TNF‐ α , IL‐6 were also examined. Identification estimation polyphenol constituents present carried out...
Hepatic ischemia/reperfusion (I/R) injury leads to oxidative stress and acute inflammatory responses that cause liver damage have a considerable impact on the postoperative outcome. Much research has been performed develop possible protective techniques. We aimed investigate efficacy of SPA0355, synthetic thiourea analog, in an animal model hepatic I/R injury. Male C57BL/6 mice underwent normothermic partial ischemia for 45 min followed by varying periods reperfusion. The animals were...