A5100748169- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- PARP inhibition in cancer therapy
- Inflammatory Biomarkers in Disease Prognosis
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- Quinazolinone synthesis and applications
- Cancer, Lipids, and Metabolism
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Lymphatic System and Diseases
- Metabolomics and Mass Spectrometry Studies
- Platelet Disorders and Treatments
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- Global Cancer Incidence and Screening
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Muscle Physiology and Disorders
- Complement system in diseases
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Cancer Research and Treatments
The University of Texas MD Anderson Cancer Center
2021-2025
Sookmyung Women's University
2015-2024
Kyung Hee University
2013
Evodiamine, an alkaloid contained in traditional Asian herbal medicines that have been used for hundreds years, is interesting due to its cytotoxic effects against many cancers. We examined the effect of evodiamine on cancer stem cell (CSC) population and bulk cultured cells (BCC) colon cancers examine double targeting effect. found three lines' BCC CSC are effectively targeted by evodiamine. Evodiamine was able suppress proliferation induce apoptosis captured G2/M phase, as previously...
The elimination of the cancer stem cell (CSC) population may be required to achieve better outcomes therapy. We evaluated stearoyl-CoA desaturase 1 (SCD1) as a novel target for CSC-selective in colon cancer. CSCs expressed more SCD1 than bulk cultured cells (BCCs), and blocking expression or function revealed an essential role survival CSCs, but not BCCs. CSC potential selectively decreased after treatment with inhibitor vitro vivo. suppression was mediated through induction apoptosis....
Spatial statistics are crucial for analyzing clustering patterns in various spaces, such as the distribution of trees a forest or stars sky. Advances spatial biology, single-cell transcriptomics, enable researchers to map gene expression within tissues, offering unprecedented insights into cellular functions and disease pathology. Common methods deriving relationships include density-based (quadrat analysis, kernel density estimators) distance-based (nearest-neighbor distance [NND], Ripley's...
The interactions between platelets and cancer cells activate enhance tumor growth. Platelets increase proliferation epithelial–mesenchymal transition in cells, inhibit anoikis, the extravasation of protect circulating against natural killer cells. Here, we have identified another mechanism by which dampen immune attack on We found that can blunt antitumor response increasing expression inhibitory checkpoint (PD-L1) ovarian vitro vivo. increased PD-L1 via contact-dependent (through NF-κB...
Among the many stilbenoids found in a variety of berries, resveratrol and pterostilbene are particular interest given their potential for use cancer therapeutics prevention. We purified four from R. undulatum that inhibits cell proliferation more efficiently than rhapontigenin, piceatannol resveratrol. To investigate underlying mechanism this superior action on cells, we utilized reverse-phase protein array followed by bioinformatic analysis ATM/CHK pathway is modified lung line. Given...
Cancerstem-like cells (CSLCs) contribute to the initiation and recurrence of tumors their resistance conventional therapies. In this study, small interfering RNA (siRNA)-based screening ~4800 druggable genes in 3-dimensional CSLC cultures comparison 2-dimensional bulk U87 glioma revealed 3 groups essential for following: survival population only, bulk-cultured or both populations. While diverse biologic processes were associated with siRNAs reducing population, CSLC-eliminating enriched a...
We investigated the role of TONSL, a mediator homologous recombination repair (HRR), in stalled replication fork double-strand breaks (DSBs) cancer. Publicly available clinical data (tumors from ovary, breast, stomach and lung) were analyzed through KM Plotter, cBioPortal Qomics. Cancer stem cell (CSC)-enriched cultures bulk/general mixed (BCCs) with RNAi employed to determine effect TONSL loss cancer lines stomach, lung, colon brain. Limited dilution assays ALDH used quantify CSCs. Western...
The association between daily protein intake and osteoporosis is still controversial only a few studies have explored the issue in Korea. This study investigated relationship prevalence of Korean adults.This analyzed data extracted from National Health Nutrition Examination Survey 4. Participants were aged 19 years or older had never been treated for osteoporosis. percentage calories coming was assessed by 24-hour recall method, participants divided into three groups according to recommended...
Abstract We and other investigators have shown that platelets promote metastasis the growth of tumors. Our rationale for conducting this study is platelets’ prometastatic progrowth effects depend on a close encounter between cancer cells. This interaction occurs inside blood vessels with circulating tumor cells outside residing in parenchyma. hypothesis was platelet extravasation required effect growth. Platelets respond to environmental stimuli by activation G protein–coupled receptors...
Abstract Resistance to radiation therapy significantly affects the prognosis of solid tumors. Histone deacetylase 6 (HDAC6) is a stress-responsive lysine that has emerged as promising target for cancer therapy, with numerous clinical trials investigating interventions modulate its activity. While HDAC6 appears be linked responses DNA-damaging therapeutics, reported and underlying mechanisms remain intriguing varied. In this study, we elucidate novel mechanism radioresistance mediated by in...
Abstract Previously, we found that an important homologous recombination repair protein ‘Tonsoku Like, DNA Repair Protein’ (TONSL) might be required for glioblastoma cancer stem cell (CSC). In this study, further investigated the role of TONSL in CSC from several lines different tissues. We also analyzed clinical data available public databases to find impact TONSL. The higher expression is associated with worse prognosis lung and gastric cancer. Interestingly, breast cancer, while its...
Abstract Melanoma is an aggressive skin cancer that develops from the malignant transformation of pigment-producing cells, melanocytes. The incidence cutaneous melanoma remarkably high, with estimated number new cases in United States 2022 close to 100,000 patients. Several previous reports pointed out effect complement system progression melanoma, although precise mechanism largely unknown. a crucial component innate immunity, and it also has significant role adaptive immunity regulating...
Many aminodihydroquinoline compounds have been studied to determine their cytotoxicity cancer cells. However, anti-cancer stem cells (CSCs) activity of has not tested in spite that CSC is believed do an important roles chemotherapy resistance and recurrence. The selective targeting activities 10 recently synthesized 2-aminodihydroquinoline analogs were examined on CSCs bulk culture a glioblastoma cell line. A diethylaminopropyl substituted aminodihydroquinoline, 5h, showed strong anti-CSC...
ARL2 regulates the dynamics of cytological components and is highly expressed in colon cancer tissues. Here, we report novel roles cell nucleus stem cells (CSCs). at relatively low levels K-RAS active cells, but its expression induced CSCs. Depletion results M phase arrest exclusively non-CSC cultured cells; addition, DNA break stress accumulates CSCs leading to apoptosis. positively associated with all six RAD51 family genes, which are essential for homologous recombination repair (HRR)....
Abstract ARL2 is a small GTP binding protein mediates many cytosolic functions including localization of Ras, dynamics microtubule and fission mitochondria but its nuclear function not well elucidated yet. Here we present the novel role in human cancer nucleus stem cells (CSC). The tissue gene expression data Human Protein Atlas Cancer Genome showed possible pro-cancer colon cancers. single cell RNA seq analysis suggests cells. activation mutant K-Ras harboring expressed less than wild type...