<b><i>Objectives:</i></b> To compare plasma kisspeptin, serum leptin, and retinol-binding protein 4 (RBP4) levels in women with without polycystic ovary syndrome (PCOS) to correlate these among each other clinical, hormonal, metabolic parameters. <b><i>Methods:</i></b> Ninety women, including 54 PCOS 36 PCOS, participated this study. For all patients, history physical examinations were performed blood samples collected between days 3 8 of a...

Recently, proteomic technologies have demonstrated that several proteins are differently expressed in various body fluids of patients with endometriosis compared those without this condition. The aim study was to investigate secreted urine using techniques order identify potential markers for the clinical diagnosis endometriosis. Urine samples were collected from women undergoing laparoscopy different indications including pelvic masses, pain, suspicious endometriosis, infertility and...

In Brief Objective The aim of this study was to evaluate the effects red ginseng (RG) on menopausal symptoms and cardiovascular risk factors in postmenopausal women. Methods A randomized, placebo-controlled, double-blind clinical trial conducted with women between ages 45 60 years. total 72 were randomly assigned either an RG group (supplemented 3 g RG, including mg ginsenosides, per day) or a placebo for 12 weeks. We analyzed changes (the Kupperman index menopause rating scale), (lipid...

This study aimed to investigate the association between serum levels of 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome along with its associated risk factors in Korean postmenopausal women. was performed using data from KNHANES 2008-2010 included 4,364 Clinical other objective characteristics, seasonality, presence five components were evaluated correlated 25(OH)D. Although no statistically significant associations observed 25(OH)D prevalence syndrome, adjusted OR for elevated blood...

The aim of this study was to compare intrafollicular biomarkers thiol-redox system and chronic inflammation in infertile patients with without endometriosis, examine correlations between IVF outcomes. included 65 receiving IVF: 31 endometriosis vs 34 endometriosis. Follicular fluid (FF) obtained from a single-dominant follicle during oocyte retrieval stored at -70 °C. Malondialdehyde, superoxide dismutase, glutathione (GSH), peroxidase 3 (GPX3), thioredoxin (TRX), TRX-binding protein 2...

Improper activity of bone-resorbing osteoclasts results in low bone density and deterioration structure, which increase the risk fractures. Anti-resorptive therapies targeting have proven effective preserving mass, but these therapeutic agents lead to defective new formation numerous potential side effects. In this study, we demonstrate that recombinant adeno-associated virus, serotype 9 (rAAV9) can deliver an artificial microRNA (amiR) silences expression key osteoclast regulators, RANK...

To evaluate risk factors leading to non-alcoholic fatty liver disease (NAFLD) occurrence in polycystic ovarian syndrome (PCOS) women. A retrospective cohort study of a total 586 women diagnosed with PCOS aged 13-35 years at the gynecology department university hospital was done phenotype, metabolic (MetS) diagnosis, body composition, insulin sensitivity, sex hormones, lipid profile, function, and transient elastography (TE). In NAFLD compared those without, MetS diagnosis (Hazard ratio [HR]...

Background/Objectives: The prognosis of endometriosis-related ovarian clear cell carcinoma (OCCC) versus non-endometriosis-associated OCCC remains unclear. We examined the impact endometriosis on diagnosis and progression assessed whether prior surgical intervention for endometriotic cysts affects prognosis. Methods: In this retrospective study (2006–2024), patients were classified as or endometriosis-related. A subgroup analysis compared with without a history cyst surgery. Results: average...

The aims of this study were to assess changes in muscle mass and strength according bone mineral density (BMD) after alendronate-calcitriol therapy subsequent common biomarkers for osteoporosis sarcopenia establish a strategy against these coexisting conditions.Thirty-eight women with osteopenia without conditions affecting calcium metabolism, inflammatory cytokines, acute chronic medical conditions, regular endurance exercise completed the study. Appendicular lean BMD measured, relative...

Oxidative stress has been proposed as a potential factor associated with the establishment and progression of endometriosis. Although few studies have shown possible mechanisms which may play roles in development, endometriosis, are known regards initiation disease, especially relationship endometrium. The aim our study was to investigate whether normal endometrium be changed by Damage-associated molecular patterns (DAMPs), contribute developing pathologic induce Endometrial tissues were...

The aim of this study was to assess the correlation between bone mineral density (BMD), arterial stiffness, and coronary atherosclerosis in healthy postmenopausal women.We performed a retrospective review 152 women who visited health promotion center for routine checkup, after excluding participants had factors affecting BMD artery disease. evaluated by dual-energy x-ray absorptiometry lumbar spine femur. Arterial stiffness measured brachial-ankle pulse wave velocity (baPWV), assessed 64-row...

Problem The aim of this study was to evaluate osteopontin (OPN) mRNA expression in eutopic endometrium and plasma OPN levels patients with endometriosis. Method A total 79 histologically confirmed endometriosis 43 without participated study. endometrial tissues measured by real‐time quantitative polymerase chain reaction (PCR) concentrations were quantified using a specific commercial sandwich enzyme‐linked immunosorbent assays (ELISA). Results Osteopontin tissue significantly higher women...

The purpose of this study is to evaluate the level and pattern cyclooxygenase-2 (Cox-2) expression in endometriosis investigate correlation between Cox-2 several clinicosurgical parameters.Twenty-six patients with 21 other benign gynecological conditions were enrolled. eutopic endometrium was sampled by pipelle, fragments ovarian endometrioma non-endometriotic cysts during surgery. Total RNA isolation semiquantitative reverse transcriptase polymerase chain reaction performed.The mRNA (mean...

Although the levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in reducing recurrence of endometriosis-associated pain, its efficacy preventing endometrioma questionable. We compared postoperative use LNG-IUS with oral contraceptives (OC) for recurrence.A retrospective cohort study.Medical university hospital.Ninety-nine women endometriomas.A chart review was performed reproductive age who had undergone laparoscopic surgery followed by three cycles gonadotropin-releasing...

This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity examine their association with radiographic knee osteoarthritis (OA) pain in Korean postmenopausal women. cross-sectional utilized data from National Health Nutrition Examination Surveys 2009-2011. The participants were categorized into 4 groups based on body composition: either (appendicular skeletal muscle < 23%) or not, obese (body mass index ≥ 25.0 kg/m2) not. OA was calculated. effect hormone...

To investigate the effect of pectinase-treated Panax ginseng (GINST) in cellular and male subfertility animal models. Hydrogen peroxide (H2O2)-induced mouse spermatocyte GC-2spd cells were used as an vitro model. Cell viability was measured using MTT assay. For vivo study, GINST (200 mg/kg) mixed with a regular pellet diet administered orally for 4 mo, changes mRNA protein expression level antioxidative spermatogenic genes young aged control rats compared real-time reverse transcription...

Although a variety of factors have been reported as affecting pregnancy rates after intrauterine insemination (IUI), there conflicting results on prognostic factors. This study aimed to determine predictive for in patients undergoing the first four IUI cycles.A total 348 cycles using clomiphene citrate or letrozole combined with gonadotropin, gonadotropin only were analyzed. Baseline clinical characteristics, variables related ovulation induction and sperm parameters compared between...

This research aimed to evaluate the potential therapeutic effects of Rg3 on endometriosis and identify target miRNAs. We designed an in vitro study using human endometrial stromal cells (HESCs) obtained from patients with vivo mouse models. HESCs were treated Rg3-enhanced red ginseng extract (Rg3E); real-time PCR microarray profiling, transfection, western blot performed. Mouse models developed supplemented Rg3E for 8 weeks. Gross lesion size fibrotic character analyzed RNA levels Ki-67,...