A5040027626- AI in cancer detection
- Sphingolipid Metabolism and Signaling
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Pharmaceutical Quality and Counterfeiting
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Viral-associated cancers and disorders
- Analytical Chemistry and Chromatography
- Cancer Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Plant Toxicity and Pharmacological Properties
- Retinoids in leukemia and cellular processes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- HER2/EGFR in Cancer Research
- Peptidase Inhibition and Analysis
- Thyroid Cancer Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Advanced Chemical Sensor Technologies
- Advancements in Transdermal Drug Delivery
- Peripheral Neuropathies and Disorders
Dankook University
2018-2025
Chungbuk National University
2014-2024
Dankook University Hospital
2020-2023
Yonsei University
2023
Severance Hospital
2023
Cheongju University
2021
Government of the Republic of Korea
2021
Chungnam National University
2016-2018
Chungnam National University Hospital
2017
National University College
2016
Abstract Platinum-based chemotherapy is the cornerstone treatment for female high-grade serous ovarian carcinoma (HGSOC), but choosing an appropriate patients hinges on their responsiveness to it. Currently, no available biomarkers can promptly predict responses platinum-based treatment. Therefore, we developed Pathologic Risk Classifier HGSOC (PathoRiCH), a histopathologic image–based classifier. PathoRiCH was trained in-house cohort ( n = 394) and validated two independent external cohorts...
Obesity is a risk factor for numerous metabolic disorders such as type 2 diabetes, hypertension, and coronary heart disease. Adipocyte differentiation triggered by adipocyte hyperplasia, which leads to obesity. In this study, the inhibitory effect of sulforaphane, an isothiocyanate, on adipogenesis in 3T3–L1 cells was investigated. Sulforaphane decreased accumulation lipid droplets stained with Oil Red O inhibited elevation triglycerides adipocytes (half‐maximal concentration = 7.3 µmol/l)....
Circulating cell-free microRNAs (miRNAs) are potential cancer biomarkers. The aim of this study was to identify miRNAs that differentially expressed between benign pleural effusion (BPE) and lung adenocarcinoma-associated malignant (LA-MPE). expression level miRNA investigated in 107 patients with effusion. Microarrays were used screen 160 a discovery set comprising 20 samples (ten BPEs ten LA-MPEs). Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) validate...
Hinokitiol (1), a tropolone-related natural compound, induces apoptosis and has anti-inflammatory, antioxidant, antitumor activities. In this study, the inhibitory effects of 1 were investigated on human colon cancer cell growth tumor formation xenograft mice. HCT-116 SW-620 cells derived from cancers found to be similarly susceptible 1, with IC50 values 4.5 4.4 μM, respectively. Compound induced S-phase arrest in cycle progression decreased expression levels cyclin A, E, Cdk2. Conversely,...
Ceramide is the most abundant lipid in epidermis and plays a critical role maintaining epidermal barrier function. Overall ceramide content keratinocyte increases parallel with differentiation, which initiated by supplementation of calcium and/or vitamin C. However, metabolic enzymes responsible for generation response to C still unclear. Here, we investigated whether alters regulating expression activity its enzymes. When human keratinocytes were grown 1.2 mM (50 μg/ml) 11 days, bulk...
Background: We address the application of artificial intelligence (AI) techniques in thyroid cytopathology, specifically for diagnosing papillary carcinoma (PTC), most common type cancer. Methods: Our research introduces deep learning frameworks that analyze cytological images from fine-needle aspiration cytology (FNAC), a key preoperative diagnostic method PTC. The first framework is patch-level classifier referrred as "TCS-CNN" based on convolutional neural network (CNN) architecture,...
Background: We address the application of artificial intelligence (AI) techniques in thyroid cytopathology, specifically for diagnosing papillary carcinoma (PTC), most common type cancer. Methods: Our research introduces deep learning frameworks that analyze cytological images from fine-needle aspiration cytology (FNAC), a key preoperative diagnostic method PTC. The first framework is patch-level classifier referred as “TCS-CNN”, based on convolutional neural network (CNN) architecture, to...
The metabolism of arachidonic acid, in particular the generation prostaglandins (PGs), has been proposed to play a key role regulation labor. Moreover, several extracellular proteins have reported modulate PG synthesis amnion cells. In this study, we found that lipid components dissolved amniotic fluid WISH human cells and identified one these as sphingosine 1-phosphate (S1P). express S1P receptors including S1P1, S1P2, S1P3. When were stimulated with S1P, PGE2 increased...
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) plays a crucial role in tumorigenesis of lung cancer. However, the therapeutic potential for anti CEACAM6 monoclonal antibody (mAb) has only been limitedly explored. Here, we evaluate naked mAb against adenocarcinoma. Clone 8F5, recognizing B domain CEACAM6, is established by immunizing A549 cells and screening clones double positive CEACAM6-Fc recombinant protein. We found that 85.7% 70 resected adenocarcinoma tissue...
Liquid‐based cytology (LBC) is being increasingly used for body fluid specimens and has improved diagnostic accuracy when compared to conventional smears. We the cellular morphologic features between CellprepPlus® LBC ThinPrep® in effusion cytology. One hundred eighty specimens, consisting of 119 pleural 59 peritoneal 2 pericardial were obtained from 166 patients. Equal volumes each specimen preparations. Sensitivity, specificity, positive negative predictive values evaluated. In addition,...
The BRAF V600E mutation is the most common genetic event in papillary thyroid carcinoma (PTC). mutational status has a significant diagnostic and prognostic role PTC since it can be detected 32%-87% of by various molecular methods.A novel, fully automated real-time PCR-based Idylla test assessed to detect formalin-fixed paraffin-embedded (FFPE) samples.99 11 nodular hyperplasia FFPE tissues are evaluated for tests compared with peptide nucleic acid-clamping PCR, PCR pyrosequencing.The...