A5037191860- Sphingolipid Metabolism and Signaling
- Pharmacological Effects of Natural Compounds
- Lipid Membrane Structure and Behavior
- Fungal Biology and Applications
- Endoplasmic Reticulum Stress and Disease
- Polysaccharides and Plant Cell Walls
- Magnolia and Illicium research
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Bioactive Compounds and Antitumor Agents
- Mycotoxins in Agriculture and Food
- Cancer-related Molecular Pathways
- Drug Transport and Resistance Mechanisms
- Tea Polyphenols and Effects
- Bioactive natural compounds
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Cholesterol and Lipid Metabolism
- Pancreatitis Pathology and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Cell death mechanisms and regulation
- Atherosclerosis and Cardiovascular Diseases
- Phytochemicals and Antioxidant Activities
Chungbuk National University
2014-2024
National University College
2023
New Generation University College
2023
Cheongju University
2012
Dong-A University
2007
University of California, Berkeley
2004
National Heart Lung and Blood Institute
1999
National Institutes of Health
1999
Pohang University of Science and Technology
1996-1998
Agricultural Research Service
1992-1996
Obesity is a risk factor for numerous metabolic disorders such as type 2 diabetes, hypertension, and coronary heart disease. Adipocyte differentiation triggered by adipocyte hyperplasia, which leads to obesity. In this study, the inhibitory effect of sulforaphane, an isothiocyanate, on adipogenesis in 3T3–L1 cells was investigated. Sulforaphane decreased accumulation lipid droplets stained with Oil Red O inhibited elevation triglycerides adipocytes (half‐maximal concentration = 7.3 µmol/l)....
In the course of screening anti-adipogenic activity natural products employing preadipocyte cell line, 3T3-L1 as an in vitro assay system, EtOAc fraction stem barks Fraxinus rhynchophylla DENCE (Oleaceae) showed significant inhibitory on adipocyte differentiation assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led to isolation six coumarins such esculetin (1), scopoletin (2), fraxetin (3), fraxidin (4) esculin (5) and fraxin (6). Among isolated,...
Hinokitiol (1), a tropolone-related natural compound, induces apoptosis and has anti-inflammatory, antioxidant, antitumor activities. In this study, the inhibitory effects of 1 were investigated on human colon cancer cell growth tumor formation xenograft mice. HCT-116 SW-620 cells derived from cancers found to be similarly susceptible 1, with IC50 values 4.5 4.4 μM, respectively. Compound induced S-phase arrest in cycle progression decreased expression levels cyclin A, E, Cdk2. Conversely,...
Nonalcoholic fatty liver disease (NAFLD) is becoming one of the most common chronic diseases in world. One features NAFLD hepatic fat accumulation, which further causes steatosis, fibrosis, and inflammation. Saponins, major pharmacologically active ingredients isolated from Panax notoginseng, contain several ginsenosides, have various pharmacological therapeutic functions. However, ginsenoside-specific molecular mechanism saponins remains unknown. This study aimed to elucidate effects...
We have previously reported that green tea catechins (GTC) display a potent antithrombotic activity, which might be due to antiplatelet rather than anticoagulation effects. In the current study, we investigated mechanism of GTC. tested effects GTC on aggregation human platelets and binding fluorescein isothiocyanate–conjugated fibrinogen platelet glycoprotein (GP) IIb/IIIa. inhibited collagen-, thrombin-, adenosine diphosphate (ADP)-, calcium ionophore A23187–induced washed platelets, with...
Obesity, which is characterized by excessive fat accumulation, associated with several pathological disorders, including metabolic diseases. In this study, the anti-obesity effect of 6,8-diprenylgenistein (DPG), a major isoflavonoid Cudrania tricuspidata fruits was investigated using high fat-diet (HFD)-induced obese mice at doses 10 and 30 mg/kg for six week. The body weight DPG-treated groups significantly lower compared to HFD-treated group. addition, accumulation in epididymal adipose...
Clinical studies regarding chemotherapy for gastric cancer patients with malignant ascites have been classically rather limited in scope, largely because peritoneal seeding produces no measurable lesions, and generally exhibited poor performance status. Herein, we evaluated the efficacy toxicity of a fortnightly modified FOLFOX-4 (m-FOLFOX) regimen.Gastric cytologically confirmed were treated cycles oxaliplatin at 85 mg/m(2) plus leucovorin 20 on first day treatment, followed by...
Advanced melanoma is the most virulent form of cancer and has a poor prognosis. In previous study, myriocin, an inhibitor serine palmitoyltransferase, was found to suppress cell proliferation by cycle arrest at G2/M phase through decreased sphingolipid levels increased p53 p21waf1/cip1 expression.Citation1 present myriocin (1 mg/kg, every other day for 3 weeks) administered intradermally or intraperitoneally mice. Tumor formation significantly inhibited intradermal intraperitoneal...
In a previous study, we reported that ginseng extract has anxiolytic-like effects in the elevated plus-maze model and saponin fraction plays an important role. This experiment was performed to investigate of ginsenosides Rb1, Rg1, Rg3-R, Rg3-S, Rg5 Rk mixture isolated from plus-maze. Furthermore, anxiolytic-effects were compared with those well-known active anxiolytic drug (diazepam). The oral administration ginsenoside Rb1 significantly increased number open arm entries time spent on...