A5004454668- Quantum and electron transport phenomena
- Physics of Superconductivity and Magnetism
- Semiconductor Quantum Structures and Devices
- Vestibular and auditory disorders
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Acute Myeloid Leukemia Research
- Surface and Thin Film Phenomena
- Semiconductor materials and devices
- Magnetic properties of thin films
- Molecular Junctions and Nanostructures
- Chronic Myeloid Leukemia Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Trigeminal Neuralgia and Treatments
- Advanced MRI Techniques and Applications
- Lung Cancer Treatments and Mutations
- Atomic and Subatomic Physics Research
- Ocular Surface and Contact Lens
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hearing, Cochlea, Tinnitus, Genetics
- Hematopoietic Stem Cell Transplantation
- Metastasis and carcinoma case studies
- Ear and Head Tumors
Chungnam National University
2021-2025
Seoul National University Bundang Hospital
2021
Korea Research Institute of Standards and Science
1999-2018
Dong-A University Hospital
2004-2014
Dong-A University
2003-2012
National Cancer Center
2009
Soonchunhyang University
2008-2009
Maryknoll Medical Center
2004
Electronics and Telecommunications Research Institute
1996-1998
Radiotherapy (RTx) is a highly effective treatment for head and neck cancer that can cause concurrent damage to surrounding healthy tissues. In cases of nasopharyngeal carcinoma (NPC), the auditory apparatus inevitably exposed radiation fields sustains considerable damage, resulting in dysfunction. To date, little research has been conducted on changes induced by RTx middle ear underlying mechanisms involved. Dexamethasone (DEX) widely used clinical practice because its immunosuppressive...
Endoscopic resection is commonly used for early gastric cancer (EGC) in Korea and Japan. There are only a few reports of metachronous after endoscopic resection. The aim this study was to identify clinical factors associated with resection.A total 176 patients EGC who had underwent submucosal dissection (ESD) were periodically followed-up examinations from January 2004 December 2007. incidence variable investigated retrospective study.The median interval between the diagnosis primary first...
In this study, we prepared and evaluated an injectable poloxamer (P407) hydrogel formulation for intratympanic (IT) delivery of dexamethasone (DEX).DEX-loaded P407 hydrogels were characterized in terms thermogelation, drug loading capacities, particle size, release. The vivo toxicity absorption the DEX-loaded after IT injection using animal model by performing histopathological analysis concentration measurements.The effectively solubilized hydrophobic DEX demonstrated a sustained release...
Clinical studies regarding chemotherapy for gastric cancer patients with malignant ascites have been classically rather limited in scope, largely because peritoneal seeding produces no measurable lesions, and generally exhibited poor performance status. Herein, we evaluated the efficacy toxicity of a fortnightly modified FOLFOX-4 (m-FOLFOX) regimen.Gastric cytologically confirmed were treated cycles oxaliplatin at 85 mg/m(2) plus leucovorin 20 on first day treatment, followed by...
Fascin is an actin‐binding protein that provides mechanical support and cell motility, involves cancer metastasis. We investigated fascin expression in gastric assessed their relationship with clinicopathologic parameters survival rates. In addition, we researched galectin‐3 to study action mechanisms. performed immunohistochemisty antibodies 471 carcinomas, using tissue microarrays. was positive 14.9% (70/471) of the samples, related worse rates ( P < 0.001), high clinical stage T nodal...
ObjectiveThis phase II study was designed to assess the safety and efficacy of a modified FOLFIRI regimen (irinotecan with bi-weekly, low dose leucovorin (ldLV) bolus continuous infusion 5-fluorouracil (5-FU)) as salvage therapy for patients advanced or metastatic gastric cancer.
Obesity is an independent risk factor for hearing loss. Although attention has focused on major obesity comorbidities such as cardiovascular disease, stroke, and type 2 diabetes, the impact of sensorineural organs, including auditory system, unclear. Using a high-fat diet (HFD)-induced obese mouse model, we investigated diet-induced sexual dimorphism in metabolic alterations sensitivity.Male female CBA/Ca mice were randomly assigned to three groups fed, from weaning (at 28 days) 14 weeks...
The use of injectable hydrogel formulations for targeted drug delivery into the inner ear has gained considerable interest. In this study, we introduce a novel self-degradable prodrug blend thermogel system designed to deliver anti-inflammatory drug, dexamethasone (DEX), in controlled and safe manner effective treatment diseases. Our approach involves blending thermogelling polymer, hexanoyl glycol chitosan (HGC), with polymer prodrug, conjugated (GC-DEX), create suitable intratympanic...
Benign metastasizing leiomyoma (BML) is composed of well-differentiated smooth muscle cells and dense connective tissue. BML affects middle-aged women who have had previous hysterectomies due to a histologically benign-appearing uterine leiomyoma. We report here on case from the in 39-year-old woman that involved soft tissues, skeletal muscles, lungs breasts. She underwent hysterectomy for leiomyoma, double oophorectomy hormonal ablation lung wedge resection confirm diagnosis. The...
The authors investigated the protein expression of double‐stranded RNA‐activated kinase (PKR), which was identified by using a previous cDNA microarray study, to discover PKR's correlations with several pathological parameters and elucidate its role in neoplastic transformation progression lung adenocarcinomas. Immunohistochemistry for PKR performed semiquantitative scoring method calculated based on staining intensity percentage immunoreactive tumor cells (high vs low) one...
Mesenchymal stem cells (MSC) are multipotent in nature and believed to facilitate the engraftment of hematopoietic (HSC) when transplanted simultaneously animal studies even human trials. In this study, we transfected culture-expanded MSC with granulocyte macrophage-colony stimulating factor (GMCSF) cell (SCF) cytokine genes then cotransplanted mononuclear (MNC) further promote HSC engraftment. MNC were harvested from cord blood seeded long-term culture for ex vivo expansion. A total 1 x...
To gain molecular understanding of carcinogenesis breast cancer, gene expression profiles were analyzed using cDNA microarray representing 4,600 cDNAs in 10 cancer samples and the adjacent noncancerous tissues from same patients. The alterations levels confirmed by reversetranscription PCR four randomly selected genes. Genes that differently expressed identified. 106 (of which 55 known) 49 28 genes up- or down-regulated, respectively, greater than 60% samples. In tissues, related to cell...
Several previous studies have addressed the association between hepatitis C virus (HCV) infection and non-Hodgkin lymphoma (NHL), but there are few on HCV-related diffuse large B-cell (DLBL). We conducted this retrospective study to investigate distinctive clinical characteristics outcome for HCV-positive DLBL. compared outcomes of 32 DLBL cases from nine Korean institutions with those 371 HCV-negative cases. A higher percentage were associated old age (≥60) than at diagnosis (59.4% vs....
This study was conducted to clarify the frequency of BRAF mutation in primary melanomas and its correlation with clinicopathologic parameters.We analyzed patients cutaneous melanoma (n=58) or non-cutaneous one (n=27) by performing dual priming oligonucleotide-based multiplex real-time polymerase chain reaction isolate purify DNA from formalin-fixed paraffin-embedded tumors.The found 17.2% (10/58) 11.1% (3/27) those melanoma. The not correlated any parameters exception patient age....
The primary ovarian lymphoma is a rare disease with poor prognosis. incidence of autoimmune hemolytic anemia in patients non-Hodgkin's estimated at 3%. However, substantial portion the previously reported cases actually represented involvement by more diffuse lymphomatous process. If stringent criteria are used for case selection, true usually carries favorable We present malignant ovary accompanied 29-yr-old patient. After ablative surgery, hemoglobin level and reticulocyte count were...