A5029314782- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Infectious Diseases and Tuberculosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Congenital Diaphragmatic Hernia Studies
- Tumors and Oncological Cases
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Antifungal resistance and susceptibility
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Treatments and Mutations
- Fungal Infections and Studies
- Dysphagia Assessment and Management
- Whipple's Disease and Interleukins
- Histiocytic Disorders and Treatments
- Lung Cancer Research Studies
Chungbuk National University Hospital
2012-2025
Chungbuk National University
2012-2023
National University College
2020-2023
New Generation University College
2020-2023
Weatherford College
2022-2023
Pulmonary and Critical Care Associates
2021
Catholic University of Korea
2020
Chungnam National University Hospital
2020
Inje University Ilsan Paik Hospital
2020
Sahmyook University
2012-2013
The increasing worldwide incidence of extensively drug-resistant tuberculosis (XDR-TB) has emerged as a threat to public health and (TB) control. Treatment outcomes have varied among studies, data on long-term survival are still scarce.To retrospectively assess the burden, clinical characteristics, treatment outcomes, rate patients with XDR-TB in cohort HIV-negative multidrug-resistant (MDR-TB) South Korea.Medical records were reviewed newly diagnosed or retreated for MDR-TB from 2000 2002....
Rationale: Few large-scale studies have investigated multidrug-resistant tuberculosis (MDR-TB) treatment outcomes relative to drug-resistance patterns.Objectives: To assess the impact of additional drug resistances on and long-term survival in a large HIV-negative MDR-TB cohort.Methods: Treatment patients with newly diagnosed or retreated 2000 2002 were retrospectively analyzed based patterns after 5–8 years follow-up.Measurements Main Results: Of 1,407 MDR-TB, 75 (5.3%) had extensively...
<b><i>Background:</i></b> Few studies have investigated the impact of diabetes mellitus (DM), a globally increasing metabolic disease, on treatment outcomes and long-term survival in patients with multidrug-resistant forms tuberculosis (MDR-TB). <b><i>Objectives:</i></b> We analyzed large cohort to assess DM MDR-TB. <b><i>Methods:</i></b> MDR-TB newly diagnosed or retreated between 2000 2002 followed for 8-11 years were...
Although remimazolam is an ultra-short-acting benzodiazepine with a shorter elimination half-life and faster recovery time than midazolam, studies evaluating its safety efficacy during bronchoscopy are limited. This study aimed to compare the of those midazolam for bronchoscopy. prospective randomized parallel-group was conducted at single institution. The primary outcome from end procedure full alertness. Other procedural parameters, satisfaction profiles, adverse effects were thoroughly...
Poor nutrition increases disease severity and mortality in patients with tuberculosis (TB). There are gaps our understanding of the effects being underweight or overweight on TB relation to sex.We generated a nationwide registry database assessed body mass index (BMI) pulmonary TB. The cause death was further classified as TB-related non-TB-related deaths. First, logistic regression analysis performed assess association between BMI (a continuous variable) mortality, subgroup analyses...
Purpose The accurate and timely diagnosis of malignant pleural effusion (MPE) in lung cancer patients is important because MPE has a poor prognosis classified as stage IV disease. Molecular biomarkers for effusion, such circulating extracellular microRNAs (miRNAs) isolated from fluid, may help the MPE. present study examined whether miRNAs that are deregulated (miR-134, miR-185, miR-22) can serve diagnostic markers adenocarcinoma-associated (LA-MPE). Materials Methods Real-time reverse...
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) plays a crucial role in tumorigenesis of lung cancer. However, the therapeutic potential for anti CEACAM6 monoclonal antibody (mAb) has only been limitedly explored. Here, we evaluate naked mAb against adenocarcinoma. Clone 8F5, recognizing B domain CEACAM6, is established by immunizing A549 cells and screening clones double positive CEACAM6-Fc recombinant protein. We found that 85.7% 70 resected adenocarcinoma tissue...
Malignant pleural effusion (MPE) is a common complication of cancer cell metastasis to the pleura. Discrimination between MPE and benign necessary design treatment strategies. Cytology important for diagnosis MPE. Carcinoembryonic antigen (CEA) an epithelial biomarker with strong staining pattern in adenocarcinomas. Here, diagnostic performances liquid-based cytology (LBC), block (CB) preparation, CEA immunostaining detection malignancy were compared large case series.In single institution,...
Herpes virus entry mediator (HVEM) is a newly discovered member of the tumor necrosis factor receptor (TNFR) superfamily that has role in herpes simplex entry, T cell activation and immunity. We generated mAb against HVEM detected soluble (SHVEM) sera patients with various autoimmune diseases. was constitutively expressed on CD4+ CD8+ cells, CD19+ B CD14+ monocytes, neutrophils dendritic cells. In three-way MLR, 122 139 were agonists 108 had blocking activity. An ELISA developed to detect...
Background/Aims Real-time, convex probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is used for the staging of malignant mediastinal lymph nodes. We evaluated diagnostic efficacy and safety EBUS-TBNA when as an initial tool. Methods retrospectively studied 56 patients who underwent tool between August 2010 December 2011. Procedure purpose were classified into four categories: 1) intrathoracic masses adjacent to central airway; 2) enlarged nodes concurrent...
Abstract Background Subclinical tuberculosis (TB) is a potential target for public health intervention because its early identification may reduce TB transmission. We aimed to describe the clinical and laboratory findings of subclinical disease among pulmonary patients compared treatment outcomes active diseases. Methods In this prospective cohort study, we enrolled adult aged ≥ 19 years with between 2016 2018. was defined as radiographic or microbiologic test results consistent without...
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare neoplasm arising from the antigen-presenting cells of immune system. This disease usually involves lymph nodes, and rarely, extranodal sites may be affected. The authors report a case IDCS presenting in pleura. A 32-yr-old man presented with progressive chest pain. Imaging studies showed diffuse pleural thickening effusion. Morphological immunohistochemical analysis incisional biopsy pleura were consistent diagnosis IDCS;...
Mucormycosis is a fatal opportunistic fungal infection that typically occurs in immunocompromised patients. The classical manifestation of mucormycosis rhinocerebral infection, and although primary gastrointestinal uncommon, it has an extremely high mortality rate Furthermore, cases immunocompetent host are rarely reported. Here, we describe our experience male patient, with no underlying disease, who succumbed to bowel infarction caused by intestinal during mechanical ventilatory care for...
Assessing the illness perception of patients with tuberculosis (TB) could improve our understanding their beliefs about disease and help address problems in health-seeking behavior.We assessed pulmonary TB association patients' demographic, socioeconomic, clinical features.Adult who were newly diagnosed at three tertiary hospitals South Korea included from November 2016 September 2018. Participants' was using Brief Illness Perception Questionnaire (BIPQ) start anti-TB treatment.In total, 390...
We previously reported that the extract from cuttlebone (CB) has wound healing effect in burned lesion of rat. In present study, main component CB was analyzed and its activity evaluated by using vitro acute inflammation model. The stimulated macrophages to increase production TNF-α. also enhanced TGF-β VEGF, which were involved angiogenesis fibroblast activation. treatment with proliferation murine fibroblast. induced activation secretion matrix metalloproteases 1 (MMP1). constituent...
Background: Liberation and extubation are important for patients supported by mechanical ventilation.Extubation success is related to the duration of an intensive care unit (ICU) stay mortality rate.High-flow nasal cannula (HFNC) oxygen therapy has physiological clinical benefits in respiratory care.The present study compared outcomes associated with HFNC conventional (COT) among at high risk reintubation.Methods: A single-center randomized trial was conducted between March 2018 June...
Cavitary pulmonary tuberculosis (TB) is associated with poor outcomes, treatment recurrence, higher transmission rates, and the development of drug resistance. However, reports on its clinical characteristics, factors, outcomes are lacking. Hence, this study sought to evaluate factors cavitary TB outcomes. We retrospectively evaluated 410 patients drug-susceptible in a university hospital Korea between 2014 2019. To TB, multivariable logistic regression was performed adjustments for...
[corrected] The radiographic characteristics of tuberculous pneumonia in adults are similar to primary tuberculosis that occurs childhood, and upper lobe cavitary is the hallmark postprimary tuberculosis. purpose this study was investigate factors associated with by making comparison tuberculosis.The medical records findings patients pneumonia, who were diagnosed between March 2003 February 2006, analyzed retrospectively.Forty had sixteen pneumonia. Fever more frequent for whereas hemoptysis...
Background: Data on the clinical characteristics of delayed treatment initiation among pulmonary tuberculosis (TB) patients are lacking. Thus, this study aimed to identify factors associated with in culture-confirmed TB and assess outcomes treatment.
Aspergillus tracheobronchitis is a form of invasive pulmonary aspergillosis in which the infection limited predominantly to tracheobronchial tree. It occurs primarily severely immunocompromised patients such as lung transplant recipients. Here, we report case 42-year-old man with diabetes mellitus, who presented intractable cough, lack expectoration sputum, and chest discomfort. The patient did not respond conventional treatment antibiotics antitussive agents, he underwent bronchoscopy that...