A5062206020- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Developmental Biology and Gene Regulation
- Bone and Dental Protein Studies
- Ultrasound and Hyperthermia Applications
- Facial Nerve Paralysis Treatment and Research
- Cleft Lip and Palate Research
- Cell Adhesion Molecules Research
- Craniofacial Disorders and Treatments
- Orthodontics and Dentofacial Orthopedics
- Intensive Care Unit Cognitive Disorders
- Orthopedic Infections and Treatments
- Facial Rejuvenation and Surgery Techniques
- Epilepsy research and treatment
- Color Science and Applications
- Cytokine Signaling Pathways and Interactions
- Osteomyelitis and Bone Disorders Research
- Advanced optical system design
- Mesenchymal stem cell research
- Anesthesia and Sedative Agents
- dental development and anomalies
- Wnt/β-catenin signaling in development and cancer
- Image Enhancement Techniques
- Fibroblast Growth Factor Research
- Connective Tissue Growth Factor Research
Kagoshima University
2017-2024
Tokyo Medical and Dental University
2024
Chungbuk National University Hospital
2023
Although remimazolam is an ultra-short-acting benzodiazepine with a shorter elimination half-life and faster recovery time than midazolam, studies evaluating its safety efficacy during bronchoscopy are limited. This study aimed to compare the of those midazolam for bronchoscopy. prospective randomized parallel-group was conducted at single institution. The primary outcome from end procedure full alertness. Other procedural parameters, satisfaction profiles, adverse effects were thoroughly...
Bone morphogenetic protein (BMP)9 has been reported to be the most potent BMP induce bone formation. However, details of BMP9‐transduced intracellular signaling remain ambiguous. Here, we have investigated signal transduction mechanisms BMP9 in comparison BMP2, another inducer formation, osteoblasts. In a mouse osteoblast cell line, induced higher mRNA levels alkaline phosphatase (ALP) and runt‐related transcription factor 2 (Runx2) than BMP2 within h. Unlike rapid phosphorylation glycogen...
Osteopontin (OPN) is expressed in various cell types including osteoblasts. OPN expression level robustly increased during osteoblast differentiation. Although was initially found as a secretory protein (sOPN), recent reports identified the intracellular isoform of (iOPN). Distinct functions each osteoblasts, however, are not well established. Here, using Tet-On inducible system, we examined role Induced overexpression wild type (wtOPN), which includes both sOPN and iOPN, significantly...
Bone marrow stromal cells (BMSCs) are multipotent that can differentiate into adipocytes and osteoblasts. Inadequate BMSC differentiation is occasionally implicated in chronic bone metabolic disorders. However, specific signaling pathways directing have not been elucidated. Here, we explored the roles of spleen tyrosine kinase (Syk) We found Syk phosphorylation was increased early stage, whereas its protein expression gradually decreased during adipogenic osteogenic two mouse mesenchymal...
Bone morphogenetic protein (BMP) 9 is one of the most osteogenic BMPs, but its mechanism action has not been fully elucidated. Hes1, a transcriptional regulator with basic helix-loop-helix domain, well-known effector Notch signaling. Here, we find that BMP9 induces periodic increases Hes1 mRNA and expression in osteoblasts, presumably through an autocrine negative feedback mechanism. BMP9-mediated induction significantly inhibited by ALK inhibitor overexpression Smad7, inhibitory Smad....
Lipoteichoic acid (LTA) and lipopolysaccharide (LPS) are cell wall components of Gram-positive Gram-negative bacteria, respectively. Notably, oral microflora consists a variety bacterial species, osteomyelitis the jaw caused by dental infection presents with symptoms bone resorption osteosclerosis. However, effects LTA LPS on osteogenic differentiation have not yet been clarified. We examined osteoblasts found that alone promoted alizarin red staining at low concentrations inhibited it high...
Abstract Bone morphogenic protein 9 (BMP9) is one of the most potent inducers osteogenic differentiation among 14 BMP members, but its mechanism action has not been fully demonstrated. Hes1 a transcriptional regulator with basic helix‐loop‐helix (bHLH) domain and well‐known Notch effector. In this study, we investigated functional roles early induction by BMP9 in mouse mesenchymal stem cell line, ST2. mRNA was transiently periodically induced ST2, which inhibited signal inhibitors inhibitor....
인위적인 기후 변화를 유발하는 이산화탄소 배출량을 줄이기 위해 제로에너지 건축이 법제화 되었으나, 종래의 건물 일체형 태양광 모듈은 발전 효율을 최대화하기 흑색으로만 제작되었기에 심미성을 중요시하는 건축물의 외관에 적용하는데 장애물이 되어왔다. 본 연구에서는 마이크로-플레이트릿 광간섭 안료를 이용한 태양광용 고투과 컬러 유리의 제작에 대해 소개하도록 한다. 안료의 함량이 광학 투과율에 미치는 영향을 조사함으로써 색상을 구현하는데 요구되는 최소 함량을 결정하였다. 3wt% 안료 함량의 유리로 모듈을 제조하고 전기적 특성을 측정하였다. 사용은 진공 증착 다층 박막 적층법으로 구현하는 방식보다 저렴한 인쇄 공정을 적용할 수 있기 때문에 제조 비용을 절감할 있으며, 효율도 기존 모듈의 76.15%에 이르렀다.
Abstract Aim It is widely known that orthognathic surgery affects changes in facial soft tissue morphology. However, the effect of on expression remains to be verified. The purpose this study was examine pros and cons effects skeletal Class III patients. Methods Fifteen patients (5 males, 10 females) were captured pre‐surgery at 6 months' post‐surgery using Kinect camera while performing movements (opening mouth, smiling, blowing). three‐dimensional coordinates, amount movement, velocity...