A5080975508- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Angiogenesis and VEGF in Cancer
- Phagocytosis and Immune Regulation
- Ear Surgery and Otitis Media
- Optical Coherence Tomography Applications
- Ear and Head Tumors
- Immune cells in cancer
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Retinal and Macular Surgery
- Human Motion and Animation
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Advanced Biosensing Techniques and Applications
- Simulation and Modeling Applications
- Extracellular vesicles in disease
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic aneurysm repair treatments
- Social Robot Interaction and HRI
- Renal and Vascular Pathologies
- Medical Imaging Techniques and Applications
- Phytoplasmas and Hemiptera pathogens
- Cervical and Thoracic Myelopathy
Korea Advanced Institute of Science and Technology
2020-2024
Inflammation plays a pivotal role in the pathogenesis of acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events.
Photoactivation targeting macrophages has emerged as a therapeutic strategy for atherosclerosis, but limited targetable ability of photosensitizers to the lesions hinders its applications. Moreover, molecular mechanistic insight phototherapeutic effects on atheroma is still lacking. Herein, we developed macrophage near-infrared fluorescence (NIRF) emitting phototheranostic agent by conjugating dextran sulfate (DS) chlorin e6 (Ce6) and estimated feasibility in murine atheroma. Also,...
In endoscopic optical coherence tomography, a transparent protective sheath is used to protect the optics and tissue. However, causes astigmatism, which degrades transverse resolution signal-to-noise ratio due cylindrical lens effect. Generally methods for correcting this astigmatism are complex, difficult control precisely, high-cost, increase dimensions of imaging probe. To overcome these problems, we have developed an astigmatism-corrected probe with epoxy window. The precisely...
Abstract Imaging the Eustachian tube is challenging because of its complex anatomy and limited accessibility. This study fabricated a fiber-based optical coherence tomography (OCT) catheter investigated potential for assessing anatomy. A customized OCT system an imaging catheter, termed OCT, were developed visualizing tube. Three male swine cadaver heads used to image acquisition subsequent histologic correlation. The was introduced through nasopharyngeal opening reached toward middle ear....
BACKGROUND: Atherosclerosis is a chronic inflammatory disease causing fatal plaque rupture, and its key aspect failure to resolve inflammation. We hypothesize that macrophage-targeted near-infrared fluorescence emitting photoactivation could simultaneously assess macrophage/lipid-rich plaques in vivo facilitate inflammation resolution. METHODS: fabricated Dectin-1–targeted photoactivatable theranostic agent through the chemical conjugation of fluorescence–emitting photosensitizer chlorin e6...
Background/Objectives: Vascular spotty calcification is an actively regulated biological process resulting in plaque vulnerability. We investigated the feasibility of a novel alendronate-based near-infrared fluorescence (NIRF)-emitting probe to specifically target atherosclerotic murine model vivo using our customized high-resolution multichannel intravital molecular imaging system (IVFM). Methods/Results: have fabricated calcium-binding NIRF by chemically coupling alendronate, specific...
Introduction: Autophagy plays a protective role in atherosclerosis and can promote efferocytosis of apoptotic cells. Photoactivation is promising tool for treating cardiovascular disease, induces autophagy macrophages-derived foam cells, however, regulation by photoactivation atherosclerotic plaque remains unknown. Objective: The present study aims to investigate whether macrophage targeted light activation enhances inflamed plaques Methods Results: Targeted photoactivatable agent showed...
Background/Objectives: Micro-calcification is a major target for high-risk plaque but the mechanistic linkage with macrophage-driven inflammation remains questionable. To address this issue, we newly innovated dual-targeted multimodal imaging strategy calcifying inflammatory activity by integration of intravascular OCT near-infrared fluorescence (NIRF) molecular imaging. Methods/Results: We fully integrated NIRF OCT. Novel emitting probe targeting micro-calcification was fabricated...
Backgrounds: Atherosclerosis is a chronic inflammatory disease causing fatal plaque rupture and its key aspect failure to resolve inflammation. We hypothesized that macrophage targeted near-infrared fluorescence (NIRF) emitting photoactivation could simultaneously in vivo assess the inflamed high-risk plaques facilitate inflammation resolution. Method results: newly synthesized Dectin-1 photoactivatable theranostic agent by chemical conjugation of photosensitizer chlorin e6 (Ce6) ligand...
Photoactivation is a promising theranostic tool to image and stabilize the atherosclerotic plaque by apoptosis induction in macrophages or other vascular cells; however, lack of effective drugs mechanistic understanding hinder its clinical application for cardiovascular disease. Here, we developed macrophage targeted photosensitizer delivery strategy demonstrated that imaging assisted light activation reduced inflammation burden plaques. Mechanistically, photoactivation induced autophagy...
We successfully acquired a comprehensive three-dimensional imaging of swine Eustachian tubes using catheter-based OCT. The OCT images clearly identified the structure and tissue components tube, which was confirmed by corresponding histological images. In addition, after balloon dilation visualized expanded luminal area quantitatively. is expected to be applicable diagnosis research tube disorder providing real-time assessment.
Introduction and Hypothesis: Photoactivation has emerged as an innovative therapeutic strategy for coronary high-risk plaque without metallic remnants, however, limited targetable ability of photoactivator lack imaging guidance hinders its application to clinics. To solve these unmet needs, we developed intravascular photoactivation guided by dual-modal OCT-NIRF structural-molecular using a novel theranostic NIRF-emitting photoactivator. Methods Results: Photoactivatable agent targeting...
Background/Objectives: Spotty calcification linked with macrophage activity is a major target for high-risk plaque but the biological interconncetion remains questionable. To address this issue, we newly developed intravascular multimodal imaging strategy by fully integration of OCT dual-targeted near-infrared fluorescence (NIRF) molecular using customized osteogenic and targetable probes. Methods/Results: We integrated structural NIRF imaging. Scale-up novel emitting probe targeting was...
Introduction: We evaluated local endothelial shear stress (ESS) distribution and arterial healing response of a thin-strut bioresorbable scaffold (BRS, 100μm) compared to 157μm-thickness ABSORB. Hypothesis: Thinner-strut design is known promote stent healing, however, there has been lack in vivo imaging evidence on how strut thickness affect process. Methods: BRS ABSORB were implanted left anterior descending circumflex arteries pigs (n=7). Detailed scaffolded-artery 3D model was...