A5073004789- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nerve injury and regeneration
- Autism Spectrum Disorder Research
- Epigenetics and DNA Methylation
- RNA regulation and disease
- S100 Proteins and Annexins
- Vitamin C and Antioxidants Research
- CRISPR and Genetic Engineering
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Blood properties and coagulation
- Genetics and Neurodevelopmental Disorders
- Nitric Oxide and Endothelin Effects
- Erythrocyte Function and Pathophysiology
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Single-cell and spatial transcriptomics
- Exercise and Physiological Responses
Johnson University
2021-2024
Rutgers, The State University of New Jersey
2021-2024
University of Central Florida
2013-2023
Rutgers Sexual and Reproductive Health and Rights
2022
Rutgers Health
2021-2022
Dongguk University
2022
Kyung Hee University Medical Center
2017-2020
Florida College
2011-2018
Kyung Hee University
2010-2017
Kaw Nation
2011
Transglutaminase 2 (TGase 2) expression is increased in inflammatory diseases. We demonstrated previously that inhibitors of TGase reduce nitric oxide (NO) generation a lipopolysaccharide (LPS)-treated microglial cell line. However, the precise mechanism by which promotes inflammation remains unclear. found activates transcriptional activator nuclear factor (NF)-κB and thereby enhances LPS-induced inducible nitric-oxide synthase. NF-κB via novel pathway. Rather than stimulating...
Parkinson's disease (PD) is classically characterized by motor symptoms; however, non-motor symptoms (NMS) are increasingly recognized as relevant in disease-state, given the associated alterations mood (depression and anxiety) cognition. Here, particularly regards to NMS, we aimed compare motor, emotional cognitive behavior of three animal models PD that trigger dopaminergic (DAergic) degeneration on both brain hemispheres: (i) 6-hydroxydopamine (6-OHDA, 8 or 6 μg) lesion model; (ii)...
This study examined whether the cannabinoid receptor type 1 (CB(1)) contributes to survival of nigrostriatal dopaminergic (DA) neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model Parkinson's disease. MPTP induced significant loss DA and microglial activation substantia nigra (SN), visualized with tyrosine hydroxylase or macrophage Ag complex-1 immunohistochemistry. Real-time PCR, ELISA, Western blotting, immunohistochemistry disclosed upregulation proinflammatory...
Evidence suggests that the C-terminal truncation of α-synuclein is equally important as aggregation in Parkinson disease (PD). Our previous results showed an endopeptidase, matrix metalloproteinase-3 (MMP3), was induced and activated dopaminergic (DA) cells upon stress conditions. Here, we report MMP3 cleaved vitro vivo were co-localized Lewy bodies (LB) postmortem brains PD patients. Incubation with catalytic domain (cMMP3) resulted generation several peptides, peptide profiles WT (WTsyn)...
Accumulation of misfolded α-synuclein is the pathological hallmark Parkinson's disease (PD). Nevertheless, little known about mechanism contributing to aggregation and its further toxicity dopaminergic neurons. Since oxidative stress can increase expression levels α-synuclein, NADPH oxidases (Noxs), which are responsible for reactive oxygen species generation, could be major players in α-synucleinopathy. Previously, we demonstrated that Nox1 expressed neurons PD animal models as well...
The nuclear receptor, Nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular target Parkinson's disease (PD). We previously identified three Nurr1 agonists (amodiaquine, chloroquine glafenine) that share an identical chemical scaffold, 4-amino-7-chloroquinoline (4A7C), suggesting structure-activity relationship. Herein we report systematic medicinal chemistry search in which over 570 4A7C-derivatives were generated...
Abstract Abnormal autophagy may contribute to neurodegeneration in Parkinson's disease (PD). However, it is largely unknown how dysregulated by oxidative stress (OS), one of major pathogenic causes PD. We recently discovered the potential regulator gene family including Tnfaip8/Oxi‐α, which a mammalian target rapamycin ( mTOR ) activator down‐regulated OS dopaminergic neurons J. Neurochem ., 112, 2010 , 366). Here, we demonstrate that OS‐induced Tnfaip8 l1/Oxi‐β could increase unique...
Deregulation of α-synuclein encoding gene (SNCA) is one the important facets Parkinson's disease (PD) research. DNA methylation status SNCA-intron1 has been shown to regulate expression. The present study aimed at investigating whether associated with higher expression in PD. We have investigated intron1 from 16 post-mortem brain samples comprised 8 PD and control subjects using bisulfite sequencing. further correlated this protein levels substantia nigra that individual western blot...
Abstract Oxidative stress plays an essential role in the development of Parkinson’s disease (PD). 8-oxo-7,8-dihydroguanine (8-oxodG, oxidized guanine) is most abundant oxidative stress-mediated DNA lesion. However, its contributing underlying PD pathogenesis remains unknown. In this study, we hypothesized that 8-oxodG can generate novel α-synuclein (α-SYN) mutants with altered pathologic aggregation through a phenomenon called transcriptional mutagenesis (TM). We observed significantly...
Abstract Animal models of human diseases are crucial experimental tools to investigate the mechanisms involved in disease pathogenesis and develop new therapies. In spite numerous animal currently available that reproduce several neuropathological features Parkinson (PD), it is challenging have one consistently recapitulates PD conditions both motor behaviors biochemical pathological outcomes. Given that, we implemented a paradigm expose rats chronic low dose paraquat (PQ), using osmotic...
Oxidative stress is commonly implicated in aging and neurodegenerative conditions such as Parkinson's disease (PD). Mutations DJ-1 are associated with autosomal recessive early-onset PD. We investigated whether can be degraded oxidative-stressed dopaminergic neuronal cells, leading to loss of its protective role against oxidative stress. have shown previously herein that the active form matrix metalloproteinase-3 (MMP3) was accumulated dopamine-producing CATH.a cells presence MPP+. show...
Abstract Background Vitamin C (also known as L‐ascorbic acid) plays a critical role in reactive oxygen species (ROS) reduction and cell regeneration by protecting from oxidative stress. Although vitamin is widely used cosmetic therapeutic markets, there considerable evidence that easily undergoes oxidation air, pH, temperature, UV light upon storage. This deficiency of decreases its potency an antioxidant reduces the shelf‐life products containing ingredient. To overcome C, we have developed...
Purpose: Deregulation of <i>SNCA</i> encoding α-synuclein (α-SYN) has been associated with both the familial and sporadic forms Parkinson disease (PD). Epigenetic regulation plays a crucial role in PD. The intron1 harbors large unmethylated CpG island. Ten-eleven translocation methylcytosine dioxygenase 1 (TET1), island binding protein, can repress gene expression by occupying hypomethylated CpG-rich promoters, therefore could be target for TET1. We investigated whether TET1...
Abstract Age is the primary risk factor for Parkinson’s disease (PD), but how aging changes expression and regulatory landscape of brain remains unclear. Here, we present a single-nuclei multiomic study profiling shared gene chromatin accessibility young, aged PD post-mortem midbrain samples. Combined analysis along pseudopathogenesis trajectory reveals all glial cell types are affected by age, microglia oligodendrocytes further altered in PD. We evidence novel disease-associated...
Parkinson’s disease (PD) is a neurodegenerative characterized by inclusions of aggregated α-synuclein (α-Syn). Oxidative stress plays critical role in nigrostriatal degeneration and responsible for α-Syn aggregation PD. Vitamin C or ascorbic acid acts as an effective antioxidant to prevent free radical damage. However, vitamin easily oxidized often loses its physiological activity, limiting therapeutic potential. The objective this study was evaluate whether NXP031, new compound we developed...
Atopic dermatitis (AD) is a chronic inflammatory disease characterized by dry and itchy skin. Recently, it has been reported that oxidative stress involved in skin diseases, possibly including AD. Vitamin C, also referred to as ascorbic acid, vital water-soluble compound functions an essential nutrient. It plays significant role both antioxidant additive various pharmaceutical food products. Despite the fact vitamin C easily oxidized, we have developed NXP081, single-stranded DNA aptamer...