A5025812105- Malaria Research and Control
- Multicomponent Synthesis of Heterocycles
- HIV/AIDS drug development and treatment
- Chemical Synthesis and Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Mosquito-borne diseases and control
- Synthesis of Indole Derivatives
- Synthesis and Biological Evaluation
- Nanomaterials for catalytic reactions
- Skin Protection and Aging
- IoT and Edge/Fog Computing
- Trypanosoma species research and implications
- Advanced Manufacturing and Logistics Optimization
- Parasitic Infections and Diagnostics
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Berberine and alkaloids research
- Internet of Things and AI
- Parasitic infections in humans and animals
- Ammonia Synthesis and Nitrogen Reduction
- Restraint-Related Deaths
- Oxidative Organic Chemistry Reactions
- Synthesis of Organic Compounds
- Synthesis and Reactivity of Heterocycles
Indira Gandhi Medical College
2024
University of Delhi
2013-2023
Father Muller Homoeopathic Medical College
2018
Ganesh Shankar Vidyarthi Memorial Medical College
2009
The nuclear receptor, Nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular target Parkinson's disease (PD). We previously identified three Nurr1 agonists (amodiaquine, chloroquine glafenine) that share an identical chemical scaffold, 4-amino-7-chloroquinoline (4A7C), suggesting structure-activity relationship. Herein we report systematic medicinal chemistry search in which over 570 4A7C-derivatives were generated...
A novel ethylenediammonium diformate–polyethylene glycol (EDDF-PEG600) system was developed as a catalyst for the Knoevenagel condensation and initiated three-component one-pot synthesis of 4H-pyrans at room temperature with high yields in short reaction times. Further, EDDF-PEG600 catalytic recycled six times without any appreciable loss its activity hence can be termed green, environmentally benign system. plausible mechanism depicting ambiphilic nature EDDF (catalyst) PEG (promoting...
2-Substituted benzimidazoles from<italic>o</italic>-diaminobenzenes and aldehydes using CuI nanoparticles as a heterogeneous nano-catalyst O<sub>2</sub>as an oxidant were synthesised in excellent yields.
Abstract Cobalt oxide nanoparticles (size 2 to 3.5 nm) were successfully impregnated on an alumina–silica (mixed oxide) support through experimentally viable and easily reproducible protocol. The prepared material was well characterized by XRD, HR‐TEM, BET surface area, EDX XPS analyses. Porous having a high area served as protective heterogeneous which the well‐dispersed Co 3 O 4 active catalytic species for hydrazine‐mediated transfer hydrogenation of nitroarenes. About mol % catalyst in...
EDDF–ethylene glycol, an ambiphilic catalytic system has been employed for the mild and rapid synthesis of various 3-indolochromenes 3-indoloxanthenes<italic>via</italic>a one-pot MCR. Besides recyclability catalyst, present method circumvents formation any by-products.
Abstract Highly active cobalt oxide nanoparticles supported on alumina/silica (Co 3 O 4 @Al 2 /SiO ) were prepared by wet impregnation method and successfully employed for the solvent free (neat) oxidative coupling of benzyl alcohols/amines with o ‐phenylenediamines synthesis 2‐substituted benzimidazoles. The catalyst during this study was characterized various techniques like XRD, XPS, HR‐TEM, SEM‐EDAX, BET surface area ICP‐AES analysis. Porous (99:1) having high served as a protective...
To evade the possible toxicity associated with formation of quinone-imine metabolite in amodiaquine (AQ), para-hydroxyl group was replaced a -F atom, and resulting 4'-fluoro-amodiaquine (FAQ) hybridized substituted pyrimidines. The synthesized FAQ-pyrimidines displayed better vitro potency than chloroquine (CQ) against resistant P. falciparum strain (Dd2), exhibiting up to 47.3-fold activity (IC50: 4.69 nM) CQ 222 2.8-fold artesunate 13.0 nM). Twelve compounds exhibited antiplasmodial...
4-Aminoquinoline-pyrimidine-aminoalkanols displaying good<italic>in vitro</italic>antimalarial activities against both CQ-sensitive and -resistant strains of<italic>P. falciparum</italic>, together with favourable resistance-indices the predicted ADME properties, are reported.
A series of antimalarial 4-aminoquinoline-pyrimidine hybrids incorporating modified anilines at the pyrimidine end was designed and synthesized through a facile synthetic route. The present displayed excellent equipotent in vitro antiplasmodial activities against both chloroquine-sensitive (D6) chloroquine-resistant (W2) strains P. falciparum with up to 11-fold (IC50=0.033 μM) better activity than reference drug, (chloroquine, IC50=0.370 resistant strain. compounds were found be...
A 23-year-old male presented in emergency department with complaint of foreign body sensation throat after accidental ingestion live ants during suctioning a hollow rubber garden watering pipe. Immediately ingestion, he spitted most the and did warm water gargles. Despite all these measures, continued to have throat, so direct laryngoscopy was performed dead were seen adhering epiglottis pyriform fossa ([Fig. 1]). His upper gastrointestinal endoscopy done couple hours presentation that...
There are various dyestuffs species to produce reactive oxygen such as singlet O 2 and super oxide radicals. Irradiation with sun light in vitro , the dyestuff like benzanthrone, metanil yellow p ‐aminodiphenylamine were found ( 1 ) and/or superoxide radicals (O - ). However benzanthrone produces detectable amount of Although ‐ADPA) did not amounts under similar conditions. The above routinely used textiles, cosmetics, detergents, leather industries well food additives. In view fact that...
Varicose veins are strange, enlarged blood vessels caused by debilitating in the vessel divider. Such conditions that expansion weight on leg veins, for example, overweight, absence of activities, hormonal vacillations amid pregnancy and menopause, smoking; obstruction or individuals who drag out standing stationary position rehashed hard work make legs exceptionally powerless form into varicose veins. Specialists reports
A 60-year-old female patient presented with a 3-month history of moderate-intensity right upper quadrant abdominal pain, accompanied by nausea and occasional vomiting. Notably, there were no reported symptoms fever, jaundice, pruritus, or weight loss. On general physical examination, the exhibited discernible abnormalities. Liver function tests normal except raised alkaline phosphatase 740 mg/dL. Her examination revealed presence vague lump in epigastric region. ultrasonogram distended...
A 26-year-old female was brought into the emergency department in police custody with an alleged history of ingestion a packet heroin. To evade detection and law enforcement by police, accused had hastily ingested whole On examination, her vital signs oxygen saturation were normal. Her laboratory examination urine toxicology screen demonstrated no abnormalities. She explained risk leakage acute toxicity from hasty poorly secured drug. consented to endoscopic retrieval, naloxone drip surgery...
There are several low lying singlet oxygen ( 1 O 2 ) and superoxide radical (O - which important in photochemical oxidation. In our present analysis we studying chemical property of super oxide some dyestuffs species to produce reactive such as radicals. Irradiation with sun light vitro the dyestuff like benzanthrone, metanil yellow p ‐aminodiphenylamine were found and/or radicals .The dose response relationship between production when sunlight expose those (0‐25 min), (0‐12 min) for...
Abstract The advantages of the title synthesis are short reaction time, high yields, easy work‐up, and recyclability catalyst.