A5020786348- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Drug Delivery Systems
- Corneal surgery and disorders
- Drug Transport and Resistance Mechanisms
- Corneal Surgery and Treatments
- Neonatal Health and Biochemistry
- Ocular Diseases and Behçet’s Syndrome
- Advancements in Transdermal Drug Delivery
- HIV/AIDS drug development and treatment
- Retinal and Macular Surgery
- Skin Protection and Aging
- Inflammatory mediators and NSAID effects
- Connexins and lens biology
- Pharmacological Effects of Natural Compounds
- Chronic Lymphocytic Leukemia Research
- Diet, Metabolism, and Disease
- Amino Acid Enzymes and Metabolism
- Chronic Myeloid Leukemia Treatments
- Mast cells and histamine
All India Institute of Medical Sciences
2016-2025
All India Institute of Medical Sciences Bhopal
2005-2024
All India Institute of Medical Sciences Raipur
2005-2024
Shri Venkateshwara University
2021
Centre for Sight
2016-2018
Center for Disease Dynamics, Economics and Policy
2008
University of Cambridge
1999
The polyherbal eye drop (Itone™) is a mixture of aqueous distillates nineteen traditionally used ingredients that sum up to impart potency the formulation and make it useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting above claim, therefore, present study was designed evaluate (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant cytotoxicity addition evaluation intraocular penetration PHF rabbit eyes using...
Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor bioavailability of drugs (< 1%) from conventional drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in cul-de-sac, relative impermeability corneal epithelial membrane. These problems may be overcome by use situ gel-forming systems are instilled as into undergo a sol-gel transition...
Poor bioavailability (<1%) of drugs from conventional eye drops is mainly due to the various precorneal loss factors which include rapid tear turnover, systemic drug absorption through naso-lachrymal duct, transient residence time solution in cul-de-sac and relative impermeability corneal epithelial membrane. The present study describes formulation evaluation chitosan gellan gum based novel in-situ gel system activated by dual physiological mechanisms. Chitosan (a pH-sensitive polymer)...
To evaluate the efficacy of topical, systemic and targeted therapy (TST) protocol in management fungal keratitis.All cases treatment-naive smear- or culture-proven keratitis presenting between June 2013 May 2017 were recruited. The TST included initial treatment with topical natamycin 5% addition oral ketoconazole voriconazole ulcers size >5 mm, depth >50%, impending perforation. Topical 1% was case poor response at 7 to 10 days. Intrastromal intracameral antifungal injections administered...
Abstract Background Pharmacokinetics and sedative effects of sublingual dexmedetomidine have not been established in children. The primary aim was to compare peak plasma concentration, time reach concentration area under the curve with 2 μg/kg intranasal dexmedetomidine. secondary aims were depth sedation, parental separation anxiety, mask acceptance, heart rate changes, analgesic requirements recovery Method Thirty children between 12 years, weighing 10–30 kg, scheduled for surgeries...
The objective of our experiment was to study the pharmacokinetics plain and liposome-encapsulated fluconazole after an intravitreal injection (100 μg/0.1 ml) in rabbit eyes. Equal concentrations liposome-entrapped were injected intravitreally into albino rabbits through pars plana intravenous pentobarbitone anesthesia. sacrificed at various time intervals, concentration vitreous, retina-choroid, aqueous humor cornea estimated using High Performance Liquid Chromatography (HPLC). Plain showed...
With age, human retinal pigment epithelium (RPE) accumulates bisretinoid fluorophores that may impact cellular function and contribute to age-related macular degeneration (AMD). Bisretinoids are comprised of a central pyridinium, dihydropyridinium, or cyclohexadiene ring. The pyridinium A2E has been extensively studied, its quantity in the macula questioned. Age-changes distributions other bisretinoids not well characterized. We measured levels three oxidized periphery donor eyes different...
<h3>Purpose</h3> To compare the efficacy of umbilical cord serum (UCS) with amniotic membrane transplantation (AMT) in cases acute ocular chemical burns. <h3>Methods</h3> In a retrospective, interventional, comparative case series, 55 eyes grades III, IV and V burns (Dua9s classification) who presented within 3 weeks injury were evaluated. Patients treated conventional medical (CM group, 20 eyes) management alone or combined either UCS (UCS 17 AMT (AMT 18 eyes). The parameters evaluated time...
The current study was undertaken to evaluate the efficacy of a novel nano-lipoidal eye drop formulation triamcinolone acetonide (TA) for topical treatment uveitis. acetonide-loaded nanostructured lipid carriers (cTA-NLC) were developed by employing 'hot microemulsion method' using biocompatible lipids, which exhibited sustained release nature and enhanced when evaluated in vitro. vivo this tested on Wistar rats, single-dose pharmacokinetic conducted rabbits. eyes animals examined any signs...
To evade the possible toxicity associated with formation of quinone-imine metabolite in amodiaquine (AQ), para-hydroxyl group was replaced a -F atom, and resulting 4'-fluoro-amodiaquine (FAQ) hybridized substituted pyrimidines. The synthesized FAQ-pyrimidines displayed better vitro potency than chloroquine (CQ) against resistant P. falciparum strain (Dd2), exhibiting up to 47.3-fold activity (IC50: 4.69 nM) CQ 222 2.8-fold artesunate 13.0 nM). Twelve compounds exhibited antiplasmodial...