A5077599012- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Pharmaceutical studies and practices
- Oral microbiology and periodontitis research
- Lipid Membrane Structure and Behavior
- Antibiotics Pharmacokinetics and Efficacy
- Inflammatory mediators and NSAID effects
- Essential Oils and Antimicrobial Activity
- Intramuscular injections and effects
- Crystallization and Solubility Studies
- Inhalation and Respiratory Drug Delivery
- Curcumin's Biomedical Applications
- Surfactants and Colloidal Systems
- RNA Interference and Gene Delivery
- Oral and gingival health research
- Bee Products Chemical Analysis
- Natural product bioactivities and synthesis
- Synthesis and Biological Evaluation
- Antifungal resistance and susceptibility
- Carbohydrate Chemistry and Synthesis
Aneurin Bevan University Health Board
2022-2024
National Health Service
2024
Muscat College
2020-2023
Universidad Central "Marta Abreu" de las Villas (UCLV)
2023
Oman Medical College
2010-2018
Jamia Hamdard
2005-2015
Taylor's University
2014
Hamdard University
2004-2010
Weatherford College
2009
Lupin Pharmaceuticals (India)
2009
AbstractAbstractMucoadhesion in drug delivery systems has recently gained interest among pharmaceutical scientists as a means of promoting dosage form residence time well improving intimacy contact with various absorptive membranes the biological system. Besides acting platforms for sustained-release forms, bioadhesive polymers can themselves exert some control over rate and amount release, thus contribute to therapeutic advantage such systems. This paper describes aspects bioadhesion mucus...
Design, development and evaluation of novel nanoemulsion formulations for transdermal potential celecoxib The aim the present study was to investigate delivery (CXB). in vitro skin permeation profile optimized compared with CXB gel gel. Significant increase steady state flux ( J ss ), permeability coefficient K p ) enhancement ratio E r observed T1 T2 < 0.05). highest value these parameters obtained formulation T2, which consisted 2% m/m CXB, 10% oil phase (Sefsol 218 Triacetin), 50%...
Celecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration celecoxib produces serious gastrointestinal side effects. It is highly lipophilic, poorly soluble drug with bioavailability around 40% (Capsule). Therefore aim present investigation was to assess skin permeation mechanism by transdermally applied nanoemulsion formulation. Optimized oil-in-water prepared aqueous phase titration method....
Natural compounds such as polyphenols play several positive roles in maintaining the oxidative and inflammatory capacity of cells, which leads to their potential use anticancer therapeutics. There is promising evidence for vitro vivo activity many polyphenols, including resveratrol quercetin, specifically treatment colorectal cancer (CRC). a clear association between quercetin interfering with mechanistic pathways involved CRC, Wnt, P13K/AKT, caspase-3, MAPK, NF-κB, etc. These molecular...
Background: Drug delivery via oral mucosa is an alternative method of systemic administration for various classes therapeutic agents. Among the mucosae, buccal and sublingual mucosae are primary focus drug delivery. Buccal offers a clear advantage over peroral route by avoidance intestinal hepatic first-pass metabolism. However, despite offering possibility improved delivery, has been utilized relatively few pharmaceutical products so far. One major limitations associated with low permeation...
Objective: In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing solubility intestinal permeability.Materials methods: Based on area obtained in pseudoternary phase diagram, various % combination Labrafac Lipophile WL 1349, Solutol HS 15, Transcutol HP distilled water were selected. Formulations which passed physical stability studies...
The aim of the present study was to assess skin permeation mechanism and bioavailability celecoxib (CXB) using novel nanoemulsion formulation. Fourier transform infrared spectra differential scanning calorimetric thermogram treated with indicated that occurred due extraction stratum corneum (SC) lipids by nanoemulsion. significant decrease in activation energy for CXB across rat SC lipid bilayers were significantly disrupted (p < 0.05). Photomicrograph sample showed disruption as distinct...
Microcrystalline cellulose (MCC) has emerged as the most resourceful excipient of all times in drug research. Thanks to its profusion terms grades available for different needs and physical properties that support a variety functionality requirements especially frequently used unit dosage forms. MCC can be bulking agent, disintegrant, binder, lubricant, glidant besides being stability enhancer secondary suspending agent. It direct compression drugs saves material, capital, equipment, labor....
The present study was aimed to evaluate the nanostrucured lipid carriers (NLC) containing duloxetine (DLX-NLC) for intranasal infusion through nasal cavity of rat. in vivo studies were performed using Wistar rats and amount DLX permeated its brain blood estimated. effects on absorption rate type drug delivery systems (nanocarriers solution) nose brain/blood permeation assessed. found be from into body rat more case DLX-NLC. Approximately 2.5-times better exhibited by DLX-NLC than...