Rakesh Kumar Sharma

ORCID: 0000-0003-0131-2228
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Research Areas
  • Advanced Drug Delivery Systems
  • Drug Solubulity and Delivery Systems
  • Radiopharmaceutical Chemistry and Applications
  • Nanoparticle-Based Drug Delivery
  • Essential Oils and Antimicrobial Activity
  • Advancements in Transdermal Drug Delivery
  • Effects of Radiation Exposure
  • Phytochemicals and Antioxidant Activities
  • Natural Antidiabetic Agents Studies
  • Pharmacological Effects of Natural Compounds
  • RNA Interference and Gene Delivery
  • Reproductive Physiology in Livestock
  • Genetic and phenotypic traits in livestock
  • Advanced MRI Techniques and Applications
  • Drug-Induced Hepatotoxicity and Protection
  • Genomics, phytochemicals, and oxidative stress
  • Heart Failure Treatment and Management
  • Plant-derived Lignans Synthesis and Bioactivity
  • Cardiac Imaging and Diagnostics
  • Disaster Response and Management
  • Phytochemistry and Biological Activities
  • Phytochemicals and Medicinal Plants
  • Food Science and Nutritional Studies
  • Drug Transport and Resistance Mechanisms
  • Ginger and Zingiberaceae research

Mangalayatan University
2023-2025

Royal Brompton Hospital
1987-2025

Chhatrapati Shahu Ji Maharaj University
2025

Graphic Era University
2024-2025

All India Institute of Medical Sciences
2016-2024

Government Medical College, Amritsar
2004-2024

Nanaji Deshmukh Veterinary Science University
2011-2024

Tropical Forest Research Institute
2024

National Institute of Technology Hamirpur
2020-2024

Dr. Yashwant Singh Parmar University of Horticulture and Forestry
2019-2024

Primary pulmonary hypertension (PPH) is a life-threatening disease. Prognostic assessment an important factor in determining medical treatment and lung transplantation. Whether cardiopulmonary exercise testing data predict survival has not been reported previously.We studied 86 patients with PPH (58 female, age 46+/-2 years, median NYHA class III) between 1996 2001 who were followed up tertiary referral center. Right heart catheterization was performed serum uric acid levels measured all...

10.1161/01.cir.0000022687.18568.2a article EN Circulation 2002-07-16

Naringenin (NRG), predominant flavanone in grapefruits, possesses anti-inflammatory, anti-carcinogenic, hepato-protective and anti-lipid peroxidation effects. Slow dissolution after oral ingestion due to its poor solubility water, as well low bioavailability following administration, restricts therapeutic application. The study is an attempt improve the of NRG by employing self-nanoemulsifying drug delivery technique. Preliminary screening was carried out select oil, surfactant...

10.3109/10717544.2013.878003 article EN Drug Delivery 2014-02-10

<h3>BACKGROUND</h3> Cystic fibrosis (CF) is the most common life threatening autosomal recessive disorder in white population. Wasting has long been recognised as a poor prognostic marker CF. Whether it predicts survival independently of lung function and arterial blood gas tensions not previously reported. <h3>METHODS</h3> 584 patients with CF (261 women) mean (SD) age 21 (7) years were studied between 1985 1996, all whom being followed up tertiary referral centre. Lung tests, body weight,...

10.1136/thorax.56.10.746 article EN Thorax 2001-10-01

Aims The correction of anaemia in chronic heart failure (CHF) has been suggested to be associated with an improvement symptoms and cardiac function. We aimed investigate the relationship between concentration haemoglobin survival CHF.

10.1016/j.ehj.2004.04.023 article EN European Heart Journal 2004-06-01

There is lot of confusion in the literatures regarding method production nanoemulsion. According to some authors, only methods using high energy like high-pressure microfluidizer or high-frequency ultra-sonic devices can produce actual nanoemulsions. In contrast this concept, one research group reported for first time preparation nanoemulsion by a low-energy method. Later on many authors about emulsification The purpose work formulate, evaluate and compare nanoemulsions prepared high-energy...

10.3109/10717544.2013.866992 article EN Drug Delivery 2013-12-13

The aim of the present study was to optimize lorazepam loaded PLGA nanoparticles (Lzp-PLGA-NPs) by investigating effect process variables on response using Box-Behnken design. Effect four independent factors, that is, polymer, surfactant, drug, and aqueous/organic ratio, studied two dependent responses, z-average % drug entrapment. Lzp-PLGA-NPs were successfully developed nanoprecipitation method as poloxamer surfactant acetone organic phase. NPs characterized for particle size, zeta...

10.1155/2014/156010 article EN cc-by BioMed Research International 2014-01-01

To formulate and optimize a herbal gel of Aloe vera extract containing Carbopol 934 as gelling agent to investigate the effects topical application on healing skin wounds surgically induced in Wistar rats.Different concentrations viscosity enhancer were tried finally that showed good spreadability consistency was selected for wound property vera. Excision model used study.The optimized evaluated different physicochemical properties property. Differences observed between various treatments...

10.4103/0973-1296.117849 article EN Pharmacognosy Magazine 2013-01-01

Abstract Plants by virtue of its composition containing multiple constituents developed during growth under various environmental stresses providing a plethora chemical families with medicinal utility. Researchers are exploring this wealth and trying to decode utility for enhancing health standards human beings. Diabetes is dreadful lifestyle disorder 21st century caused due lack insulin production or physiological unresponsiveness. The chronic impact untreated diabetes significantly affects...

10.1186/2251-6581-12-35 article EN cc-by Journal of Diabetes & Metabolic Disorders 2013-07-04

β-Galactosidases produced by microorganisms are being used in food technology for hydrolysis of lactose milk and by-products. The enzyme has attracted much attention view intolerance human population due to importance diet. β-Galactosidase hydrolyze β-galactopyranosides, that is, lactose, form a range trans-galactosylation products or galactooligosaccharides (GOS) capable providing several health benefits as prebiotics. In addition, the also finds applications production based sweeteners...

10.1111/jfbc.12564 article EN Journal of Food Biochemistry 2018-08-16

Introduction: There are few data on heart failure (HF) burden and none available the community prevalence of HF in India. We conducted a study aimed at determining rural as well tertiary hospital care setting North also reviewed existing literature regarding estimated projected Methodology: All adults (>20 years) with chronic breathlessness six villages under primary health center Northern India were identified evaluated standardized questionnaire physical examination by trained workers. was...

10.4103/2395-5414.182988 article EN cc-by-nc-sa Journal of the Practice of Cardiovascular Sciences 2016-01-01

<sup>18</sup>F-FDG PET with CT is an important advanced imaging modality used to assess patients suspected or known cardiac sarcoidosis (CS). indicated for CS work-up in extra-CS and abnormal screening results involvement, under 60 y old presenting unexplained high-grade atrioventricular heart block, idiopathic ventricular arrhythmias. In established CS, serial can be response immunosuppressive therapy long-term surveillance reactivation of myocardial inflammation low-grade quiescent...

10.2967/jnmt.124.268142 article EN Journal of Nuclear Medicine Technology 2025-02-05
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