A5022699290- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Lanthanide and Transition Metal Complexes
- RNA Interference and Gene Delivery
- Medical Imaging and Pathology Studies
- Drug Solubulity and Delivery Systems
- Peptidase Inhibition and Analysis
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Advancements in Transdermal Drug Delivery
- Bone health and treatments
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Amino Acid Enzymes and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Lipid Membrane Structure and Behavior
- HER2/EGFR in Cancer Research
- Click Chemistry and Applications
- Computational Drug Discovery Methods
Institute of Nuclear Medicine & Allied Sciences
2016-2025
Indian Institute of Technology Roorkee
2025
National Institute of Pharmaceutical Education and Research
2025
Indian Maritime University
2024
Uka Tarsadia University
2024
Defence Research and Development Organisation
2006-2023
Nanaji Deshmukh Veterinary Science University
2023
Intergovernmental Oceanographic Commission of UNESCO
2022
Shree Guru Gobind Singh Tricentenary University
2021
Cyclotron (Netherlands)
2013-2020
Intranasal drug delivery is known to overcome the blood–brain barrier (BBB) for of drugs brain. The objective this study was prepare risperidone (RSP)-loaded solid lipid nanoparticles (RSLNs) and explore possibility brain targeting by nose-to-brain delivery. RSLNs were prepared solvent emulsification–solvent evaporation method characterized content, particle size distribution, zeta potential, in vitro drug-release study. pharmacodynamic RSLNs, which performed paw test using Perspex platform,...
Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor bioavailability of drugs (< 1%) from conventional drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in cul-de-sac, relative impermeability corneal epithelial membrane. These problems may be overcome by use situ gel-forming systems are instilled as into undergo a sol-gel transition...
The objective of the present study was to optimize olanzapine nanoemulsion (ONE), for nose-to-brain delivery. nanoemulsions and mucoadhesive (OMNEs) were prepared using water titration method characterized technical electrokinetic properties. Biodistribution solution (OS) in brain blood rats following intranasal (intranasal) intravenous (intravenous) administrations examined optimized technetium-labeled (99mTc-labeled) formulations. brain/blood uptake ratios 0.45, 0.88, 0.80, 0.04 OS...
Carboxylated carbon nanotubes stand as the most promising nanovectors for biomedical and pharmaceutical applications due to their ease of covalent conjugation with eclectic functional molecules including therapeutic drugs, proteins, oligonucleotides. In present study, we attempt investigate how toxicity acid-oxidized multiwalled (MWCNTs) can be tweaked by altering degree functionalization correlate trend biodistribution profile. line that rationale, mice were exposed 10 mg/kg pristine (p)...
The self-assembly of a dehydrophenylalanine containing dipeptide (see figure), yielding highly ordered nanotubular structures, is discussed. tubes are longer and thinner than previously reported peptide-based tubular structures; they stable to boiling-water temperatures, different pH conditions, nonspecific protease (Proteinase K). Supporting information for this article available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c1774_s.pdf or from author. Please note:...
A gram-negative bacterium which was capable of oxidizing reduced inorganic sulfur compounds isolated from agricultural soil and designated BI-42. This new isolate grew on a wide range organic substrates but not able to grow autotrophically lacked ribulose 1,5-bisphosphate carboxylase, key enzyme carbon dioxide fixation. These results suggested that strain BI-42 chemolithoheterotroph. Ammonia nitrate were used as sole nitrogen sources for growth, glutamate synthase activity, resulted in...
Tumor-specific gene delivery constitutes a primary challenge in nonviral mediated therapy. In this investigation, branched polyethylenimine (bPEI, 25 kDa) was modified by forming nanoconstructs with natural polysaccharide, chondroitin sulfate (CS), to impart site-specific property. A library of CS−PEI (CP) fabricated altering the content CS and evaluated terms size, surface charge, morphology, pDNA loading efficiency, release assay, protection study, cytotoxicity, transfection efficiency....
We undertook this prospective study to compare amino acid metabolism, glucose and proliferation in primary recurrent low grade gliomas using positron emission tomography (PET)/computed with F-18 FDOPA, FDG, FLT.Fifteen patients newly diagnosed or previously treated (WHO I II) were subjected F-18-FDOPA, FLT PET/computed studies on consecutive days. This included 2 remission as control subjects. Uptake of all the 3 tracers analyzed visually quantified standardized uptake values tumor normal...
This article describes the preparation and characterization of solid lipid nanoparticles (SLNs) prepared with stearic acid (SLN-A) a mixture Compritol (SLN-B) as matrix poloxamer-188 surfactant, using sodium taurocholate ethanol co-surfactant mixture, view to applying SLN in topical ocular drug delivery. The SLNs were by o/w microemulsion technique characterized time-resolved particle size analysis, polydispersity index, zeta(ζ )-potential, differential scanning calorimetry (DSC),...
Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using simple and reproducible nanoprecipitation method. The prepared DOC loaded (PolyDOC) stable either solution or lyophilized form, showed controlled release behaviour over several days. PolyDOC high vitro toxicity after 24 h MCF-7 U87 cells compared to free DOC. Biodistribution data demonstrated that (99m)Tc labelled t(1/2) MRT...