A5015199678- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Risk and Safety Analysis
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Mesoporous Materials and Catalysis
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Occupational Health and Safety Research
- Fuel Cells and Related Materials
- RNA Research and Splicing
- Graphite, nuclear technology, radiation studies
- Information and Cyber Security
- Nuclear and radioactivity studies
- Nuclear Receptors and Signaling
- Human-Automation Interaction and Safety
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Fault Detection and Control Systems
- Cancer-related gene regulation
- Engineering Applied Research
- Sarcoma Diagnosis and Treatment
- Protein Tyrosine Phosphatases
- Energy and Environmental Systems
- Genomics and Chromatin Dynamics
Korea Research Institute of Bioscience and Biotechnology
2012-2024
Korea University of Science and Technology
2021-2024
Samsung (South Korea)
2024
Sogang University
2002-2021
Korea Atomic Energy Research Institute
2002-2021
New Generation University College
2019
Ajou University
2017
Korea Gas Corporation (South Korea)
2012
Seonam University
2000-2006
OCT-4 transcription factors play an important role in maintaining the pluripotent state of embryonic stem cells and may prevent expression genes activated during differentiation. Human isoform mRNAs encode proteins that have identical POU DNA binding domains C-terminal but differ their N-terminal domains. We report here cloning characterization human OCT-4B isoform. cDNA encodes a 265-amino acid protein with predicted molecular mass 30 kDa. Embryonic (E14141) cell-based complementation...
Schwann cells play a crucial role in successful nerve repair and regeneration by supporting both axonal growth myelination. However, the sources of human are limited for studies cell development biology treatments cell-associated diseases. Here, we provide rapid scalable method to produce self-renewing precursors (SCPs) from pluripotent stem (hPSCs), using combined sequential treatment with inhibitors TGF-β GSK-3 signaling pathways, neuregulin-1 18 days under chemically defined conditions....
Cellular skin substitutes such as epidermal constructs have been developed for various applications, including wound healing and regeneration. These cellular models are mostly derived from primary cells keratinocytes fibroblasts in a two-dimensional (2D) state, further development of three-dimensional (3D) cultured organoids is needed to provide insight into the vivo phenotype physiology. Here, we report (EpiOs) generated induced pluripotent stem (iPSCs) novel construct its application...
Mouse and human ES (embryonic stem) cells display unusual proliferative properties can produce pluripotent stem indefinitely. Both processes might be important for maintaining the 'stemness' of cells; however, little is known about how cell-cycle fate regulated in cells. Oct-4, a master switch pluripotency, plays an role state may prevent expression genes activated during differentiation. Using ZHBTc4 cells, we have investigated effect Oct-4 on control, found that down-regulation inhibits...
Costello syndrome is linked to activating mutations of a residue in the p-loop or NKCD/SAK motifs Harvey Ras (HRas). More than 10 HRas mutants that induce have been identified; G12S most prevalent these. However, certain also are cancer formation exemplified with G12V HRas. Despite these relations, specific links between types and diseases evade definition because some mutations, such as HRas, often cause cancer. This study established novel kinetic parameter-based equations estimate value...
Abstract Aging is associated with an inevitable and universal loss of cell homeostasis restricts organism's lifespan by increased susceptibility to diseases tissue degeneration. The glucose uptake producing energy for survival one the major causes ROS production under physiological conditions. However, overall mechanisms which results in cellular senescence remain mysterious. In this study, we found that TXNIP deficiency accelerated senescent phenotypes MEF cells high condition. ‐/‐ showed...
LoRaWAN is a wireless technology optimized for low data rate and wide transmission range in IoT. Several studies have reported security vulnerability the that could develop into an attack: bit-flipping attack. The attack which can change specific fields on ciphertext without decryption. In this paper, we analyze risk of might occur propose countermeasure to prevent it.
Although many cohort studies have reported that long-term exposure to particulate matter (PM) can cause lung cancer, the molecular mechanisms underlying PM-induced increase in cancer metastasis remain unclear. To determine whether PM contributes metastasis, cells were cultured with conditioned medium from PM-treated THP1 cells, and migration ability of treated was assessed. The key molecules involved identified using RNA-seq analysis. In addition, metastatic analyzed vivo by injection into...
Booster of pluripotency: RSC133, a new synthetic derivative indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming human somatic cells into pluripotent state aids growth maintenance stem (hPSCs). Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Instrumentation and control systems in nuclear power plants have been digitalized for the purpose of maintenance precise operation. This digitalization, however, brings out issues related to cyber security. In most recent past, international standard organizations, regulatory institutes, research institutes performed a number studies addressing these order provide information helpful system designers their application security systems, this paper presents methods considerations define attack...
Spliceosomes are the core host of pre-mRNA splicing, allowing multiple protein isoforms to be produced from a single gene. Herein, we reveal that spliceosomes more abundant in human pluripotent stem cells (hPSs), including embryonic (hESs) and induced (hiPSs), than non-hPSs, their presence is associated with high transcriptional activity. Supportively, spliceosomal components involved catalytically active splicing step were mainly co-localized hPS spliceosomes. By profiling gene expression...
The Oct-4 gene encodes a transcription factor that is expressed in embryonic stem (ES) cells and germ cells. known to function as transcriptional activator of genes involved maintaining an undifferentiated totipotent state possibly preventing expression activated during differentiation. In addition, it putative proto-oncogene critical player the genesis human testicular cell tumors. Although much effort has gone toward characterizing Oct-4, there still little about molecular mechanisms...
Although gastric cancer is a common cause of mortality worldwide, its biological heterogeneity limits the available therapeutic options. Therefore, identifying novel targets for developing effective targeted therapy pressing need. Here, we investigate molecular function and regulatory mechanisms Vestigial-like 1 (VGLL1) in cancer. Microarray analysis 556 tissues revealed that VGLL1 was prognostic biomarker correlated with PI3KCA PI3KCB. regulates proliferation cells, as shown live cell...
Pluripotent stem cells (PSCs) represent the most promising clinical source for regenerative medicine. However, given cellular heterogeneity within cultivation and safety concerns, development of specific efficient tools to isolate a pure population eliminate all residual undifferentiated PSCs from differentiated derivatives is prerequisite applications. In this study, we raised monoclonal antibody identified its target antigen as desmoglein-2 (DSG2). DSG2 co-localized with human PSC...
The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability innate immune cells. Here, we identified critical role thioredoxin-interacting protein (TXNIP) in production IFN-γ NK cells during bacterial infection. TXNIP inhibited and activation transforming growth factor β-activated kinase 1 (TAK1) activity primary mouse human directly interacted with TAK1 interfering complex formation between binding (TAB1). Txnip−/− (KO)...
Identifying biomarkers related to the diagnosis and treatment of gastric cancer (GC) has not made significant progress due heterogeneity tumors. Genes involved in histological classification genetic correlation studies are essential develop an appropriate for GC.In vitro vivo lentiviral shRNA library screening was performed. The expression Synaptotagmin (SYT11) tumor tissues patients with GC confirmed by performing Immunohistochemistry, between level patient's survival rate analyzed....
A series of new functionalized 3-indolylindolin-2-ones, 3-(1-methylpyrrol-2-yl)indolin-2-ones, and 3-(thiophen-2-yl)indolin-2-ones were synthesized by using novel indium (III)-catalysed reaction various 3-diazoindolin-2-ones with indoles, 1-methylpyrrole, or thiophene via one-pot procedure. The newly compounds characterized screened for their in vitro antibacterial activity against Staphylococcus species, including methicillin-resistant aureus. results revealed that five KS15, KS16, KS17,...
As a form of industrial control systems (ICS), nuclear instrumentation and (I&C) have been digitalized increasingly. This has raised in turn cyber security concerns. Cyber for ICS is important because cyber-attacks against can cause not only equipment damage loss production but also personal public safety hazards unlike general IT environments. Numerous risk analyses carried out to enhance the recently, many studies related are being conducted. Many existing considered separately. However,...
Tumour-specific chromosomal rearrangements are known to create chimaeric products with the ability generate many human cancers. hTAFII68-TEC (where hTAFII68 is TATA-binding protein-associated factor II 68 and TEC translocated in extraskeletal chondrosarcoma) such a fusion product, resulting from t(9;17) translocation found myxoid chondrosarcomas, where NTD (N-terminal domain) fused protein. To identify proteins that control function, we used affinity chromatography on immobilized (NTD)...