A5084647113- Minerals Flotation and Separation Techniques
- TiO2 Photocatalysis and Solar Cells
- Mineral Processing and Grinding
- Hippo pathway signaling and YAP/TAZ
- Clay minerals and soil interactions
- Gas Sensing Nanomaterials and Sensors
- Bone Tissue Engineering Materials
- Analytical Chemistry and Sensors
- Wnt/β-catenin signaling in development and cancer
- Recycling and Waste Management Techniques
- Soft tissue tumor case studies
- Extraction and Separation Processes
- Sarcoma Diagnosis and Treatment
- Calcium Carbonate Crystallization and Inhibition
- Advanced Photocatalysis Techniques
- Electrospun Nanofibers in Biomedical Applications
- Cervical and Thoracic Myelopathy
- Dental materials and restorations
- Esophageal and GI Pathology
- Metal Extraction and Bioleaching
- Recycling and utilization of industrial and municipal waste in materials production
- Heterotopic Ossification and Related Conditions
- Conducting polymers and applications
- Zeolite Catalysis and Synthesis
- Liver Disease and Transplantation
Korea Institute of Science and Technology
2023-2024
Seoil University
2013-2023
Seoul Veterans Hospital
2010-2022
Seoul Medical Center
2017-2022
Chungnam National University
2019-2022
Gangneung–Wonju National University
2016-2021
Korea Institute of Geoscience and Mineral Resources
2004-2020
Korea Research Institute of Bioscience and Biotechnology
2018-2019
Harvard Stem Cell Institute
2019
Korea University of Science and Technology
2018
Malignant tumors develop through multiple steps of initiation and progression, tumor is singular importance in prevention, diagnosis, treatment. However, the molecular mechanism whereby a signaling network interacting pathways restrains proliferation normal cells prevents still poorly understood. Here, we have reported that Hippo, Wnt/β-catenin, Notch form an to maintain liver size suppress hepatocellular carcinoma (HCC). Ablation mammalian Hippo kinases Mst1 Mst2 led rapid HCC formation...
No adequate randomized trials have been reported for a comparison between hepatic resection (HR) versus radiofrequency ablation (RFA) the treatment of patients with very early stage hepatocellular carcinoma (HCC), defined as an asymptomatic solitary HCC <2 cm. For compensated cirrhotic HCC, Markov model was created to simulate trial HR (group I) primary percutaneous RFA followed by cases initial local failure II) monotherapy III); each arm allocated hypothetical cohort 10,000 patients. The...
Objective Hippo signalling is a recently identified major oncosuppressive pathway that plays critical roles in inhibiting hepatocyte proliferation, survival and hepatocellular carcinoma (HCC) formation. kinase (Mst1 Mst2) inhibits HCC proliferation by suppressing Yap/Taz transcription activities. As human mainly driven chronic liver inflammation, it not clear whether shaping its inflammatory microenvironment. Design We have established genetic model deleting Mst1 Mst2 hepatocytes. Functions...
Abstract BACKGROUND. Many liver staging systems have been proposed for patients with hepatocellular carcinoma after locoregional therapy; however, controversies persist regarding which system is the best. In this study, authors compared performance of 7 in a cohort who underwent transarterial chemoembolization. METHODS. total, 131 chemoembolization between August 1998 and February 2005 were included study. Demographic, laboratory, tumor characteristics determined at diagnosis before therapy....
Mesoderm formation and subsequent anterior-posterior (A-P) axis elongation are fundamental aspects of gastrulation, which is initiated by the primitive streak (PS). Convergent extension (CE) movements epithelial-mesenchymal transition (EMT) important for A-P in vertebrate embryos. The evolutionarily conserved planar cell polarity (PCP) pathway regulates CE, Wnts regulate many gastrulation including CE EMT. However, Wnt ligands that mammalian development remain unknown. Wnt11 Wnt5a lower...
Wnt/β-catenin signaling is necessary for lymphatic vascular development. Oscillatory shear stress (OSS) enhances in cultured endothelial cells (LECs) to induce expression of the lymphedema-associated transcription factors GATA2 and FOXC2. However, mechanisms by which OSS regulates FOXC2 are unknown. We show that activates autocrine LECs vitro. Tissue-specific deletion Wntless, required secretion Wnt ligands, reveals smooth muscle complementary sources ligands regulate development vivo....
The Hippo-YAP/TAZ signaling pathway plays a pivotal role in growth control during development and regeneration its dysregulation is widely implicated various cancers. To further understand the cellular molecular mechanisms underlying Hippo regulation, we have found that activities of core components, large tumor suppressor (LATS) kinases YAP/TAZ transcription factors, oscillate mitotic cell cycle. We identified anaphase-promoting complex/cyclosome (APC/C) Cdh1 E3 ubiquitin ligase complex,...
Human papillomaviruses (HPVs) are causative agents of various diseases associated with cellular hyperproliferation, including cervical cancer, one the most prevalent tumors in women. E7 is two HPV-encoded oncoproteins and directs recruitment subsequent degradation tumor-suppressive proteins such as retinoblastoma protein (pRb) via its LxCxE motif. also triggers tumorigenesis a pRb-independent pathway through C-terminal domain, which has yet been largely undetermined, lack structural...
Titanium dioxide has excellent chemical, electrical, and optical properties, as well good chemical stability. For that reason, it is widely used in many fields of study industry, such photocatalysts, organic solar cells, sensors, dental implants, other applications. Many nanostructures TiO2 have been reported, electrospinning an efficient practical technique a low cost high efficiency. In various studies on improving performance, the researchers created nanofibers with suitable...
TiO2 nanofibers have high chemical stability and strength are applied to many fields such as air pollution sensors pollutant removal filters. ZnO also very absorptivity in that used germicides ceramic brighteners. TiO2/ZnO nanofibers, which a composite form of ZnO, were fabricated show higher photocatalytic properties than existing TiO2. The precursor, including zinc nitrate hexahydrate, polyvinyl acetate, titanium isopropoxide, was spinning solution for nanofibers. Electrospun calcined at...
We first report flotation of lepidolite by using stearyl trimethyl ammonium chloride (STAC), one the quaternary salts, without adding any depressant to get an insight on further advanced separation. X-ray diffraction patterns showed that ores obtained from Boam mine, Uljin, South Korea were mainly composed lepidolite, muscovite, quartz, calcite and albite. Zeta potential results isoelectric points (IEP) about 2.5, 2.3 9.7 for albite calcite, respectively, was determined be less than 2. Based...
To improve sensing performance, the metal oxide semiconductor (MOS) gas sensor needs to have amuch bigger specific surface area in active layer, lower power and higher sensitivity. TiO2 nanotube arrays were used for layer of a MOS because they are chemically stable electrically semi conductive. obtain clean, open window nanotubes, two-step anodic oxidation was conducted. The diameter length nanotubes 60 nm 5.5 μm, respectively. transplanted by SnO2 adhesion layer. had nanoparticle 30...
Acquiring a selective growth advantage by breaking the proliferation barrier established gatekeeper genes is centrally important event in tumor formation. Removal of mammalian Hippo kinase Mst1 and Mst2 hepatocytes leads to rapid hepatocellular carcinoma (HCC) formation, indicating that signaling pathway critical restrains abnormal hepatocytes. By rigorous genetic approaches, we identified an interacting network Hippo, Wnt/β-catenin Notch pathways control organ size HCC development. We found...