A5108081395- Antimicrobial Peptides and Activities
- Viral Infections and Immunology Research
- Energy, Environment, Economic Growth
- Insect symbiosis and bacterial influences
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- Animal Virus Infections Studies
- Mesenchymal stem cell research
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Advancements in Transdermal Drug Delivery
- Hippo pathway signaling and YAP/TAZ
- Monoclonal and Polyclonal Antibodies Research
- Mechanical and Optical Resonators
- Toxin Mechanisms and Immunotoxins
- Economic and Technological Innovation
- Cancer-related Molecular Pathways
- Innovation Diffusion and Forecasting
- Genetic factors in colorectal cancer
- Chemistry and Chemical Engineering
- Nanoplatforms for cancer theranostics
- Intracerebral and Subarachnoid Hemorrhage Research
- Liquid Crystal Research Advancements
- Influenza Virus Research Studies
- Biochemical and Structural Characterization
Guangxi University for Nationalities
2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Chinese Academy of Sciences
2008-2023
Institute of Zoology
2008-2023
Duke-NUS Medical School
2019
National Institutes of Health
2016
Chongqing Medical University
2015
Shanghai Institutes for Biological Sciences
2013
Center for Excellence in Molecular Cell Science
2013
Malignant tumors develop through multiple steps of initiation and progression, tumor is singular importance in prevention, diagnosis, treatment. However, the molecular mechanism whereby a signaling network interacting pathways restrains proliferation normal cells prevents still poorly understood. Here, we have reported that Hippo, Wnt/β-catenin, Notch form an to maintain liver size suppress hepatocellular carcinoma (HCC). Ablation mammalian Hippo kinases Mst1 Mst2 led rapid HCC formation...
Abstract Detection of biomarkers associated with body conditions provides in‐depth healthcare information and benefits to disease management, where the key challenge is develop a minimally invasive platform ability directly detect multiple in fluid. Dermal tattoo biosensor holds potential simultaneously health‐related skin interstitial fluid because features minimal invasion, easy operation, equipment‐free result reading. Herein, colorimetric dermal fabricated by four‐area segmented...
Human influenza is a seasonal disease associated with significant morbidity and mortality. Anti-flu Traditional Chinese Medicine (TCM) has played role in fighting the virus pandemic. In TCM, dandelion commonly used ingredient many therapeutic remedies, either alone or conjunction other natural substances. Evidence suggests that variety of pharmacological activities. this study, we evaluated anti-influenza activity an aqueous extract from dandelion, which was tested for vitro antiviral...
Hepatocellular carcinoma (HCC) is a common and deadly cancer with limited treatment options. Through genome-wide growth depletion screens using clustered regularly interspaced short palindromic repeats expression profiling of primary HCC tumors, we identified 13 clinically relevant target genes therapeutic potential. Subsequent functional annotation analysis revealed significant enrichment these in the cell cycle, death, survival pathways. Non-structural maintenance chromosomes condensin I...
Lanthanide-doped upconversion nanoparticles can convert long wavelength excitation radiation to short emission. They have great potential in biomedical applications, such as bioimaging, biodetection, drug delivery, and theranostics. However, there is little information available on their bioavailability biological effects after oral administration. In this study, we systematically investigated the bioavailability, biodistribution, toxicity of silica-coated administrated by gavage. Our...
As China’s aging population deepens and its pace accelerates, it is particularly crucial to rely on technological innovation drive industrial differentiation. Is there a connection between aging, innovation, differentiation? Does have moderating effect? Based the panel data of 31 provinces in China from 2006 2022, this paper constructs entropy index measure overall differentiation tertiary China, subsequently investigates relationship among three using two-way fixed effect model. The results...
Abstract Intracerebral hemorrhage (ICH) causes uncontrolled neuroinflammation/oxidative stress to aggravate secondary brain injury (SBI) for high mortality and disability but lacks effective pharmacotherapy in clinical practices. This represents an imperative need discover potential targets develop advanced therapeutic strategies. Herein, it is discovered that cell‐free DNA (cfDNA, a driving factor of inflammation) level serum positively correlates with SBI severity speculated as targeting...
Mutation and recombination are two major genetic mechanisms that drive the evolution of viruses. They both exert an interplay during virus evolution, in which mutations provide a first ancestral source diversity for subsequent recombination. Sarbecoviruses group evolutionarily related β-coronaviruses including human severe acute respiratory syndrome coronavirus (SARS-CoV) SARS-CoV-2 trove animal viruses called SARS-like CoVs (SL-CoVs). This members either use or not angiotensin-converting...
Abstract Drosomycin, the first inducible antifungal peptide isolated from Drosophila , belongs to superfamily of CSαβ‐type defensins. In present study we report a modified approach for high‐level expression drosomycin, which allows us evaluate its differential potency on filamentous fungus Neurospora crassa WT (wild type) and N. MUT16, specific resistance mutant strain plant defensins, by using different approaches. The results presented here show time that MUT16 is resistant our recombinant...
Abstract The initiation of translation in hepatitis C virus (HCV) occurs at the internal ribosome entry site (IRES) located 5′‐end its genomic RNA. To study function HCV IRES, we constructed a reporter plasmid that generates bicistronic mRNA encoding two fluorescent proteins: cap‐dependent DsRed2 and IRES‐dependent Azami Green (AG). We introduced into Huh7.5.1 HEK293 cells measured relative IRES activity from ratio AG's signal to DsRed2's individual using flow cytometry. compare our method...
The natural environment is central to life and provides essential support the ecosystem society. It our responsibility maintain safety sustainability of upon...
Objective To investigate the association of insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) gene polymorphisms with metabolic syndrome (MS) and its related phenotypes in Han population northwest China. Methods A case-control study was performed, which included 350 subjects MS (MS group) 304 without (control selected random number table from epidemiological survey database diabetes Shannxi province form 2007 to 2008. Matrix assisted laser desorption/ionization...
Conference Article| May 01 1993 Sequence-specific anti-peptide antibodies that recognize different subunits of the high-affinity IgE receptor Bin Gao; Gao 1University-Industry Centre for Pharmaceutical Research, School Pharmacy, University London, 29–39 Brunswick Square, London WCIN IAX, U.K. Search other works by this author on: This Site PubMed Google Scholar G. J. Anderson; Anderson M. Brammer; Brammer *Institute Psychiatry, De Crespigny Road, SW12 C. H. James; James Danton; Danton Toth;...