A5067957864- Effects and risks of endocrine disrupting chemicals
- Fatty Acid Research and Health
- Analytical Methods in Pharmaceuticals
- Carcinogens and Genotoxicity Assessment
- Antibiotics Pharmacokinetics and Efficacy
- Toxic Organic Pollutants Impact
- Food Quality and Safety Studies
- Education and Learning Interventions
- Analytical Chemistry and Chromatography
- Phytoestrogen effects and research
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Cholesterol and Lipid Metabolism
- Metabolomics and Mass Spectrometry Studies
- Estrogen and related hormone effects
- Diverse Approaches in Healthcare and Education Studies
- Reproductive biology and impacts on aquatic species
- Diet, Metabolism, and Disease
- DNA Repair Mechanisms
- Pharmacological Effects and Toxicity Studies
- DNA and Nucleic Acid Chemistry
- Advanced Memory and Neural Computing
- Sunflower and Safflower Cultivation
- Health and Wellbeing Research
- Diverse Topics in Contemporary Research
Korea Research Institute of Chemical Technology
2017-2025
Gyeongsang National University Hospital
2018-2020
Sungkyunkwan University
2020
Cornell University
2014
Burke Medical Research Institute
2014
MIND Research Institute
2014
Vanderbilt University
2010-2013
Chung-Ang University
2013
Catholic University of Daegu
1998-2012
Korea Institute of Science and Technology
2008-2011
Abstract Background Compound K [20- O -β-(D-glucopyranosyl)-20(S)-protopanaxadiol], a metabolite of the protopanaxadiol-type saponins Panax ginseng C.A. Meyer, has been reported to possess anti-tumor properties inhibit angiogenesis and induce tumor apoptosis. In present study, we investigated effect on apoptosis explored underlying mechanisms involved in HL-60 human leukemia cells. Methods We examined viabilities various cancer cell lines using MTT assays. DAPI assay, Annexin V PI double...
The triterpene saponin ginsenoside Rh2 has been shown to have antiproliferative effects on various cancer cells. However, the effect of cell cycle and its underlying molecular mechanism in human leukemia cells are not fully understood. In this study, we found that inhibited proliferation concentration- time-dependently with an IC 50 ~38 µM. DNA flow cytometric analysis indicated blocked progression at G 1 phase HL-60 U937 cells, was be accompanied by downregulations cyclin-dependent kinase...
Abstract The protective role of vitamin E and changes in the status several physiological antioxidants after feeding rats a fish oil diet were investigated. Six‐week‐old male Sprague‐Dawley divided into four groups fed experimental diets for 8 wk. Three (FO) menhaden soybean (SO) (9∶1) mixture as 10% (w/w) diet. These provided with ≤3, 45 or 209 IU E/kg One SO group was used control ≤45 Plasma levels, when expressed per mL plasma, extremely low FO ≤3 E, lower than SO. However, plasma levels...
Summary Aims The pathology of stroke consists multiple pro‐death processes, and CD 36 has been suggested as a multimodal target to reduce oxidative stress inflammation in ischemic stroke. Using 36‐deficient mice SS ‐31, cell permeable tetrapeptide known down‐regulate pathways, the current study investigated whether targeting is effective transient permanent Methods Wild‐type or CD36‐deficient were subjected either 30‐min focal In parallel, cohort received vehicle 5 mg/kg SS‐31. Monocyte...
Abnormal production or metabolism of steroid hormones is responsible for the development endocrine diseases. Thus, accurate quantification needed both research into clinical conditions and diagnostic monitoring purposes. An improved analytical method profiling 39 steroids in urine using LC-MS/MS was developed. As a pre-treatment procedure prior to LC-tandem mass spectrometry (LC-MS/MS) analysis, hydrolysis β-glucuronidase solid-phase extraction purifying samples were performed. Steroids...
Six polyphenolic compounds were isolated from ethylacetate extract second-ary to 80% ethanol extraction of defatted safflower seeds. They categorized into three types: lignans, flavones and serotonin derivatives. Female Sprague-Dawley rats weighing 163.4±6.3g ovariectomized (Ovx) fed either at a level 1% (w/w) or types 200 mg/leg in diet containing 0.5% cholesterol for four wk. The sham Ovx control groups the same without components. Plasma GOT GPT levels did not differ among six...
This is the first report to evaluate potential effects of microplastics (MPs) on wild wharf roaches (Ligia exotica) in a shoreline habitant. L. exotica an important plastic detritus consumer coastal area. A survey was conducted from May June years 2019 and 2020 two South Korean nearshore sites: Nae-do (as MPs-uncontaminated) Maemul-do MPs-contaminated). MPs (>20 μm size) were detected highly gastrointestinal tracts Maemul-do, at average level 50.56 particles/individual. They much lower...
The objective of this study was to assess the thyroid hormone disruption and reproductive dysfunction effects bioaccumulation rate mechanism in zebrafish exposed tris(1,3-dichloro-2-propyl) phosphate (TDCPP), with stress responsiveness. fish were test concentrations TDCPP (0, 0.06, 0.3, 1.5 µg/mL) for 21 days, accordance no observed adverse effect level (i.e., < EC10) embryos. found be significantly higher female zebrafish, while metabolic male at all studied. (triiodothyronine [T3]...
Alkylphenols, such as nonylphenol and 4-tert-octylphenol (OP), are byproducts of the biodegradation alkylphenol ethoxylates present substantial ecological health risks in aquatic environments higher life forms. In this context, our study aimed to explore effect OP on reproductive endocrine function both female male zebrafish. Over a period 21 days, zebrafish were subjected varying concentrations (0, 0.02, 0.1, 0.5 μg/L), based lowest effective concentration (EC10 = 0.48 μg/L) identified for...
Cassia tora fiber supplement consisting of 2 g soluble extracted from semen (C. L.), 200 mg alpha-tocopherol, 500 ascorbic acid, and 300 maltodextrin was formulated in a pack, given to 15 type II diabetic subjects (seven men eight women 57.1 +/- 2.9 years old) with instructions take two packs per day for months. Placebo contained only little brown caramel color. Lifestyle factors dietary intakes the were not altered during 2-month period. Serum total cholesterol moderately (P < .1) decreased...
Abstract Background To evaluate the metabolic changes in urinary steroids pre- and post-menopausal women men with papillary thyroid carcinoma (PTC). Methods Quantitative steroid profiling combined gas chromatography-mass spectrometry was used to measure concentrations of 84 both (n = 21, age: 36.95 ± 7.19 yr) female 19, 52.79 7.66 yr), male 16, 41.88 8.48 patients PTC. After comparing quantitative data their corresponding controls (pre-menopause women: n 24, 33.21 10.48 yr, post-menopause...
Volatile organic compounds (VOCs) are ubiquitous environmental pollutants that have a high vapor pressure at room temperature. Some VOCs been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC), because they can bind DNA and cause cell mutations. Therefore, monitoring of in human urine is very important evaluate correlation between exposure disease.We developed an improved analytical method simultaneous determination with wide range polarities...
This study investigates the adverse effects and associated underlying mechanism of bisphenol S (BPS) exposure on reproductive endocrine activity in adult zebrafish. Fish were exposed for 21 days to different BPS concentrations (0, 8, 40, 200 µg/mL) determined via lowest observed effect level (LOAEL, i.e., < EC15 = 250 zebrafish embryos. Exposure µg/mL female absence vitellogenic oocytes or presence degenerated ovary significantly decreased biosynthesis hepatic vitellogenin (VTG) mRNA, while...
The present study was aimed to investigate the effects of indigestible dextrin and polydextrose, soluble dietary fibers with low molecular weight, on lipid metabolism disaccharidase activities intestinal mucosa in rats fed a high sucrose diet. Their were compared those well-known fibers, pectin, guar gum, also an insoluble fiber, cellulose. Dietary added diets at 5% (w/w) level a-cellulose, dextrin, polydextrose. Male Sprague-Dawley given free access test for 6 weeks. Body weight gain lowest...
Modified nucleosides are formed by DNA repair as a result of oxidative damage and post-transcriptionally modified tRNA in cells. In the present study, profiling 14 nucleoside was investigated rat urine to evaluate bisphenol A (BPA)-induced stress after intraperitoneally injecting rats with 0, 10 or 50 mg kg(-1) per day BPA for four consecutive days. The urinary concentrations individual were measured liquid chromatography-tandem mass spectrometry combined column switching on-line extraction....
The aim of the present study was to investigate hypocholesterolemic effect and potential tyramine derivatives from Lycii Cortex Radicis (LCR), root bark lycium (Lycium chenese Miller) in reducing lipid peroxidation.The activities enzymes, hepatic 3-hydroxy 3-methylglutaryl (HMG) CoA reductase acyl-CoA:cholesterol acyltransferase (ACAT) LDL oxidation were measured vitro animal experiments also performed by feeding LCR extracts rats.The test compounds employed for trans-N-p-coumaroyltyramine...