A5101723939- Healthcare and Venom Research
- Antifungal resistance and susceptibility
- Traditional Chinese Medicine Studies
- Diverse Approaches in Healthcare and Education Studies
- Soil Mechanics and Vehicle Dynamics
- Engineering Applied Research
- Flavonoids in Medical Research
- Analytical Methods in Pharmaceuticals
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects of Natural Compounds
- Reproductive System and Pregnancy
- Protein purification and stability
- Risk and Safety Analysis
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- Powder Metallurgy Techniques and Materials
- Fungal and yeast genetics research
- Neonatal Respiratory Health Research
- Magnolia and Illicium research
- Reliability and Maintenance Optimization
- Pharmacological Effects and Assays
- High Temperature Alloys and Creep
- Cholinesterase and Neurodegenerative Diseases
- Macrophage Migration Inhibitory Factor
- Phytochemical Studies and Bioactivities
Daejeon University
2015-2023
Dunsan Korean Medicine Hospital
2015-2019
Seoul National University
2005-2015
Yonsei University
2011
National Academy of Agricultural Science
2010
Kyung Hee University
2006-2007
Galectin-1 is an anti-inflammatory lectin with pleiotropic regulatory functions at the crossroads of innate and adaptive immunity. It expressed in immune privileged sites implicated establishing maternal–fetal tolerance, which essential for successful pregnancy eutherian mammals. Here, we show conserved placental localization galectin-1 primates its predominant expression maternal decidua. Phylogenetic footprinting shadowing unveil cis motifs, including estrogen responsive element 5′...
Post-translational modifications of chromatin structure by histone acetyltransferase (HATs) play a pivotal role in the regulation gene expression and diverse biological processes. However, function GNAT family HATs, especially Elp3, opportunistic human pathogenic fungus Aspergillus fumigatus is largely unknown. To investigate roles HATs Elp3 GcnE A. fumigatus, we have generated characterized individual null Δelp3 ΔgcnE mutants. The radial growth fungal colonies was significantly decreased...
Trimeric G proteins play a central role in the protein signaling filamentous fungi and Gα subunits are major component of trimeric proteins. In this study, we characterize three human pathogen Aspergillus fumigatus. While deletion gpaB ganA led to reduced colony growth, growth ΔgpaA strain was increased minimal media. The germination rate, conidiation, mRNA expression key asexual development regulators were significantly decreased by loss gpaB. contrast, gpaA resulted conidiation levels...
Außen Bio, innen Nano: Durch Einkapselung von Platin-Nanopartikeln in einer bakteriellen Aminopeptidase resultiert ein neuartiges Hybridkonstrukt, das Platin-katalysierte Hydrierung und Peptidase-katalysierte Hydrolyse zu Mehrstufensynthesen kombinieren kann (siehe Bild). Die Übertragung dieses bioanorganischen Einkapselungskonzepts auf zahlreiche Enzyme anorganische Materialien neuartigen multifunktionalen führen.
:Clematis mandshurica RUPR. (CMR) and Erigeron annuus (L.) PERS. (EALP) have pharmacological effects including anti-inflammatory activity been used in traditional medicines Asia. However, neuroprotective of CMR and/or EALP extracts against brain ischemic insults never addressed. Thus, the aim this study was to examine YES-10, a combination from (combination ratio, 1:1), hippocampus following ischemia/reperfusion gerbils. Protection neurons investigated by cresyl violet staining, fluoro-jade...
The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic for the glycoengineered protein partner interaction unclear. Type I interferon (IFN) receptors, composed IFNAR1 IFNAR2, have different strengths, sequentially bind IFN in dominant direction, leading activation signals induces a variety biological effects. Here, we evaluated receptor-binding kinetics each state binary ternary complex formation...
Alcoholism is a significant health problem in the world. The liver first and primary target organ for alcohol metabolism. Alcohol dehydrogenase aldehyde play important roles metabolism of aldehyde. In this study, I aimed to investigate eliminatory effects Phellinus spp. extract on drunken Sprague-Dawley (SD) rats. Male SD rats were given at 30 min after 40% (5 g/kg) ingestion. To assay effect blood concentration, samples taken from tail vein 1, 3 5 h concentrations alcohol, dehydrogenase,...
2′,4′-Dihydroxychalcone (2′,4′-DHC) was identified from a heat shock protein 90 (Hsp90)-targeting library as compound with Hsp90 inhibitory and antifungal effects. In the presence of 2′,4′-DHC (8 μg/mL), radial growth Aspergillus fumigatus inhibited 20% compared to control, green pigmentation completely blocked. The expression conidiation-associated genes abaA, brlA, wetA significantly decreased (approximately 3- 5-fold) by treatment 2′,4′- DHC. calcineurin signaling components, cnaA crzA,...
Objective This study aimed to investigate the trend in research on breast cancer using traditional Korean medicine (TKM) and establish direction for further study. Methods Breast studies were searched Oriental Medicine Advanced Searching Integrated System (OASIS). The search term was âbreastâ there no restriction year. analyzed according type of research. Results 83 searched. types numbers as follows: 42 vitro studies, 5 vivo 12 review, 27 clinical including case reports. Various cell...
Critical systems with high reliability feature fault tolerant redundancy. Conventional analytical analysis methods that use the Reliability Block Diagram do not adequately reflect characteristics of redundancy management system and are suitable for this applications. This paper uses Monte-Carlo method to calculate complicated redundant systems. The was first validated cases solutions. Then, tool successfully applied analyze flight control a voter as system.
Aspergillosis is a life-threatening disease in patients with compromised immune systems. The process of fungal invasion an important step during host cell infection. We investigated the transcription factor and promoter region SFTPD, which activated infection conidia-treated cells. To investigate activity SFTPD fungal-infected cells, we cloned various lengths (−1000 to +1) examined its A549 cells treated Aspergillus fumigatus conidia. determined location within that exhibits response conidia...
높은 신뢰도를 요구하는 비행제어 시스템은 복잡한 중복구조로 구성된다. 이러한 중복 구조는 시스템의 내고장성(fault tolerant)을 향상시킬 수 있다. 따라서 시스템 설계자는 다양하게 구성될 있는 중복구조의 정량적 데이터를 바탕으로 적절한 구조를 선택할 본 논문에서는 특징을 분석하고 신뢰도 해석을 위해 필요한 수학적 모델을 정의하였다. 이렇게 정의된 해석 적용하여 Simulink 블록 기반의 Reliability Block Diagram 도구를 구성하고, 상용으로 사용되고 이용하여 분석도구의 타당성을 검증하였다. A flight control system for high reliability consists of complicated redundant structures. This redundancy can improve fault tolerant characteristics system. So, a manager is able to choose suitable...
Objectives: This report is aimed to investigate the efficacy of Korean medicine including intravenous Cultivated Wild Ginseng(Panax ginseng C.A. Meyer) Pharmacopuncture(CWGP) with intractable cervical dysplasia patient. Methods: A 49-year-old woman who was diagnosed as on Feb 2012 treated for 3 months. includes CWGP, acupuncture, moxibustion and herbal medicine. The effect therapies evaluated human papillomavirus deoxyribonucleic acid(HPV DNA) testing. And lower limb cold sense genital...
ddPCR is a highly sensitive PCR method that utilizes water-oil emulsion system. Using droplet generator, an extracted nucleic acid sample partitioned into ~20,000 nano-sized, water-in-oil droplets, and amplification occurs in individual droplets. The approach identifying sequence mutations, copy number alterations, select structural rearrangements involving targeted genes. Here, we demonstrate the use of as powerful technique for precisely quantitating rare BRAF V600E mutations FFPE...
Aspergillosis is a life-threatening disease in individuals with compromised immune systems. Fungal invasion highly critical process during host cellular infection. Several papers have reported that transcription factors are responsible for the infection process. To investigate what involved an effort to inhibit fungal into cells, I checked surfactant protein family and PU.1 factor levels A549 cells infected A. fumigatus conidia. protein-D were reduced then observed increase on...