A5065993576- Zebrafish Biomedical Research Applications
- Biochemical Analysis and Sensing Techniques
- Meat and Animal Product Quality
- melanin and skin pigmentation
- Effects and risks of endocrine disrupting chemicals
- Microplastics and Plastic Pollution
- Toxic Organic Pollutants Impact
- Neuroscience and Neuropharmacology Research
- Animal Nutrition and Physiology
- Gallbladder and Bile Duct Disorders
- Stress Responses and Cortisol
- Drug-Induced Hepatotoxicity and Protection
- Neuroinflammation and Neurodegeneration Mechanisms
- Skin Protection and Aging
- Genetic and phenotypic traits in livestock
- Photochromic and Fluorescence Chemistry
- Retinal Development and Disorders
- Pancreatic and Hepatic Oncology Research
- Olfactory and Sensory Function Studies
- Biliary and Gastrointestinal Fistulas
- Neuroendocrine Tumor Research Advances
- Advanced Glycation End Products research
- Plant-derived Lignans Synthesis and Bioactivity
- Pharmacological Effects of Medicinal Plants
- Natural Antidiabetic Agents Studies
Korea Research Institute of Chemical Technology
2017-2024
Chungnam National University
2014-2021
National Institute of Animal Science
2010-2012
The blood-brain-barrier (BBB) is made up of blood vessels whose permeability enables the passage some compounds. A predictive model BBB important in early stages drug development. predicted permeabilities drugs have been confirmed using a variety vitro methods to reduce quantities candidates needed preclinical and clinical trials. Most prior studies relied on animal or cell-culture models, which do not fully recapitulate human BBB. development microfluidic models human-derived cells could...
Microplastics, small pieces of plastic derived from polystyrene, have recently become an ecological hazard due to their toxicity and widespread occurrence in aquatic ecosystems. In this study, we exposed zebrafish larvae two types fluorescent polystyrene nanoparticles (PS-NPs) identify size-dependent effects. PS-NPs 50 nm, unlike 100 nm PS-NPs, were found circulate the blood vessels accumulate brains larvae. Behavioral electroencephalogram (EEG) analysis showed that induce abnormal...
Bisphenol F (BPF; 4,4'-dihydroxydiphenylmethane) is one of the most frequently used compounds in manufacture plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, neurodevelopment zebrafish. However, its neurotoxic effects are controversial, underlying mechanisms unclear. In order to determine whether motor system, we exposed zebrafish embryos assessed behavioral, histological, neurochemical changes. Spontaneous behavior startle...
Epilepsy is one of the most common neurological disorders, and it characterized by spontaneous seizures. In a previous study, we identified 4-(2-chloro-4-fluorobenzyl)-3-(2-thienyl)-1,2,4-oxadiazol-5(4H)-one (GM-90432) as novel anti-epileptic agent in chemically- or genetically-induced epileptic zebrafish mouse models. this investigated effects GM-90432 through neurochemical profiling-based approach to understand neuroprotective mechanism pentylenetetrazole (PTZ)-induced seizure model....
육질등급별 도체등급요인에 대한 분석 결과는 육질등급이 3등급에서 <TEX>$1^{++}$</TEX>등급으로 높아지면서 도체중, 등지방두께, 근내지방도는 증가하였으며(p<0.05) 육색, 지방색, 조직감 및 성숙도는 낮아지는 경향이었다(p<0.05). 한우고기의 이화학적 특성에서, 증가될수록 전단력은 8.29 kg에서 2.83 kg으로 감소하였고, 보수력은 52.41%에서 58.03%로, 조지방 함량은 3.57%에서 25.68%로 증가하였다(p<0.05). 기계적으로 측정한 육색에서 명도는 <TEX>$1^{++}$</TEX>등급 쇠고기가 41.53으로 가장 높았고 가열감량은 3등급쇠고기가 22.11%로 높았다(p<0.05). 도축 후 24시간에 pH는 5.53-5.66범위로 정상적인 pH 값을 나타내었다. 6점 만점으로 평가된 관능특성에서, 높아질수록 연도, 다즙성, 향미 전체평점은 다즙성(0.59), 연도(0.71), 향미(0.55) 전체평점(0.6)과 상관관계가 있었으며....
본 연구는 2009년도에 전국에서 출하된 한우 암소 및 거세우 69,159두를 대상으로 등지방두께가 도체등급요인 경락가격에 미치는 영향을 구명하였다. 평균 등지방두께는 거세우(12.57 mm)가 암소(11.93 mm) 보다 높았으며, 암소의 77.52%가 등지방두께 4-15 mm 구간에, 거세우의 85.91 %가 4-18 구간에 속하였다. 도체중(평균, 315.5 kg과 413.2 kg)과 배최장근면적(평균, 76.73 <TEX>$cm^2$</TEX>와 86.23 <TEX>$cm^2$</TEX>)은 높아짐에 따라 증가 하였으며(p<0.05), 육량등급은 C등급으로 낮아졌다(p<0.05). 근내지방도는 거세우(5.29)가 암소(3.83)보다 우수하였으며 21 mm까지 증가하였고(p<0.05), 22 이상부터 감소하였다. 성숙도는 각각 6.11과 2.12로 골화 정도가 높았으며 육색은 4.85 4.67 로써 비슷한 수준이었다. 육질등급은 1등급과 2등급의 중간 수준(평균...
한우의 근내지방도에 따른 도체등급 요인과 이화학특성 및 관능특성에 관한 기초자료를 도출하기 위하여 73,316두(2009년)의 도체와 271두(2005년-2009년)의 한우 등심을 분석하였다. 근내지방도가 1에서 9로 증가할수록 도체중, 배최장근단면적 등지방두께는 암소, 수소, 거세우에서, 직선적으로 증가하였다(p<0.05). 성숙도는 암소와 거세우에서 증가하였고 평균 암소가 6.11로 가장 높았다. 이화학 특성 분석 결과 근내지방도의 증가에 따라 전단력은 8.58 kg에서 2.60 kg으로 감소하였으며(p<0.05) 보수력은 52.09%에서 58.66%로 명도는 34.08-41.97 범위로 증가되었다(p<0.05). 일반성분 분석결과 수분함량은 근내지방도 73.62%에서 55.87%로 감소(p<0.05)하였으나 단백질함량은 유의적인 차이가 없었다. 조지방 함량은 3.07%에서 26.70%로 증가(p<0.05)하였으며, 6까지 증가율은 비슷한 경향 이었으나 8 9의 각각...
Abstract Osteoporosis affects millions of people worldwide. As such, this study assessed the macrophage-dependent in vitro anti-osteoporosis, phytochemical profile and hepatotoxicity effects zebrafish larvae stem bark extracts P. africana . Mouse bone marrow macrophages (BMM) cells were plated 96-well plates treated with methanolic at concentrations 0, 6.25, 12.5, 25, 50 µg/ml for 24 h. The osteoclast tartrate-resistant acid phosphatase (TRAP) activity cell viability measured....
Although methyl-tertiary butyl ether (MTBE) is the only clinical topical agent for gallstone dissolution, its use limited by side effects mostly arising from a relatively low boiling point (55 °C). In this study, we developed gallstone-dissolving compound containing an aromatic moiety, named 2-methoxy-6-methylpyridine (MMP) with higher (156 °C), and compared effectiveness toxicities MTBE.The dissolubility of MTBE MMP in vitro was determined placing human gallstones glass containers either...
This paper aims to validate if intrapancreatic injection of penicillin G can enhance hardness and suture holding capacity (SHC) the pancreas through prompting fibrosis process. Soft pancreatic texture is constantly mentioned as one most contributory predictors postoperative fistula (POPF). has poor SHC higher incidence parenchymal tearing, frequently leading POPF. From a library 114 antibiotic compounds, we identified that substantially enhanced in experimental mice. Specifically, injected...
성별 한우쇠고기의 품질 특성을 조사하기 위하여 육질등급이 5개로 개전된 후 첫 해인 2005년도에 전국에 출하된 42,113두의 육질등급 요인을 조사하였으며, 2005년부터 2008년도 상반기까지 국립축산과학원에서 도축된 257두의 쇠고기 품질을 분석하였다. 한우의 육질등급요인(근내지방도, 육색, 지방색, 조직감, 성숙도)은 유의적인 차이가 있었으며 한우 거세우가 가장 우수하였다(p<0.05). 근내지방도, 성숙도 및 조직감은 각각 5.02, 2.17 1.31로 우수하였으며 이에 따라 지수도 2.75(<TEX>$1^{++}$</TEX> 등급 =1, 3등급= 5)로 높았다(p<0.05). 수분함량은 수소가 73.23%로 높았으며, 조지방 함량은 17.27% 거세우의 명도(<TEX>$L^*$</TEX>), 전단력 보수력은 39.01, 4.03 kg 57.08%로 높았으나(p<0.05), 암소와 수소 간의 없었다. 전단력에 있어서 암소 7.73 8.35 kg으로 비교적 높게 나타난...
Osteoporosis is one of the main health problems in world today characterized by low bone mass and deterioration microarchitecture. In recent years, use natural products approach to treat it has been increase. this study, vitro antiosteoporosis activity hepatotoxicity P . jamasakura bark extracts were evaluated. Methods Mouse marrow macrophage (BMM) cells incubated with tartrate‐resistant acid phosphate (TRAP) buffers p ‐nitrophenyl cultured different at concentrations 0, 6.25, 12.5, 25, 50 μ...
Olfaction is an important neural system for survival and fundamental behaviors such as predator avoidance, food finding, memory formation, reproduction, social communication. However, the circuits pathways associated with olfactory in various are not fully understood. Recent advances optogenetics, high-resolution vivo imaging, reconstructions of neuronal have created new opportunities to understand circuits. Here, we generated a transgenic zebrafish manipulate signal optically, expressing...
The use of methyl-tertiary butyl ether (MTBE) to dissolve gallstones has been limited due concerns over its toxicity and the widespread recognition safety laparoscopic cholecystectomy. adverse effects MTBE are largely attributed low boiling point, resulting in a tendency evaporate. Therefore, if there is material with higher point similar or dissolubility than MTBE, it expected be an attractive alternative MTBE.To determine whether tert-amyl ethyl (TAEE), analogue relatively (102 °C), could...