A5100370246- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Carcinogens and Genotoxicity Assessment
- Per- and polyfluoroalkyl substances research
- Mercury impact and mitigation studies
- Mass Spectrometry Techniques and Applications
- Korean Urban and Social Studies
- Adipose Tissue and Metabolism
- Extraction and Separation Processes
- Recycling and Waste Management Techniques
- Estrogen and related hormone effects
- Remote Sensing and LiDAR Applications
- Metal Extraction and Bioleaching
- Ecology and Conservation Studies
- Neuroscience and Neuropharmacology Research
- Land Use and Ecosystem Services
- Pharmaceutical and Antibiotic Environmental Impacts
- Wildlife-Road Interactions and Conservation
- Ecology and Vegetation Dynamics Studies
- Robotics and Sensor-Based Localization
- Peroxisome Proliferator-Activated Receptors
- Pharmacogenetics and Drug Metabolism
- Air Quality and Health Impacts
- Wildlife Ecology and Conservation
Kyung Hee University
2015-2024
Korea Institute of Science and Technology
2023
Sogang University
2023
Ehime University
2002-2022
Pukyong National University
2018
Flemish Institute for Technological Research
2017
Suwon Research Institute
2013-2015
Korea Environment Institute
2012-2013
Changwon National University
2013
Seoul National University
2013
Long-term potentiation (LTP) is typically studied using either continuous high-frequency stimulation or theta burst stimulation. Previous studies emphasized the physiological relevance of frequency; however, synchronized hippocampal activity occurs over a broader frequency range. We therefore tested at intervals from 100 msec to 20 sec (10 Hz 0.05 Hz). LTP Schaffer collateral-CA1 synapses was obtained 5 sec, with maximal 350-500 (2-3 Hz, delta frequency). In addition, short-duration present...
Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induce various toxic effects through the aryl hydrocarbon receptor (AhR) signaling pathway. Here, we investigated structural and functional characteristics molecular evolution of multiple AhRs in black-footed albatross (Phoebastria nigripes) common cormorant (Phalacrocorax carbo). We report complementary DNA sequences two distinct AhRs, designated AhR1 AhR2, from these species as well identification an AhR2-like gene sequence...
Concentrations of perfluorochemicals (PFCs) including perfluoroalkylsulfonates (PFSAs) and perfluoroalkylcarboxylates (PFCAs) were determined in liver serum Baikal seals (Pusa sibirica) collected from Lake Baikal, Russia 2005. Among the 10 PFC compounds measured, perfluorononanoic acid (PFNA, 3.3–72 ng/g wet wt) concentrations highest liver, followed by perfluorooctanesulfonate (PFOS, 2.6–38 ng/g). The accumulation profile long-chain (C7-C12) PFCAs particular, predominance PFNA, indicated...
A model is developed that predicts exposure and absorbed dose for chemical contaminants in household drinking water via three pathways: inhalation, direct indirect ingestion, dermal penetration. Extensive probability distributions building characteristics, activity use patterns, operating conditions of devices, physiological characteristics the general population are developed. The impacts different on mass transfer coefficients shower, bath, washing machine, dishwasher, faucet established....
Recognizing and localizing queried objects in range images plays an important role for robotic manipulation navigation. Even though it has been steadily studied, is still a challenging task scenes with occlusion clutter. We present novel approach to object recognition that boosts dissimilarity between similar-shaped background the scene by maximizing use of visibility context. design new point pair feature containing discriminative description inferred from Also, we propose pose estimation...
Long-term potentiation (LTP) is often induced experimentally by continuous high-frequency afferent stimulation (HFS), typically at 100 Hz for 1 s. Induction of LTP requires postsynaptic depolarization and voltage-dependent calcium influx. more effective if the same number stimuli are given as a series short bursts rather than HFS, in part because excitatory potentials (EPSPs) become strongly depressed during reducing depolarization. In this study, we examined mechanisms EPSP depression HFS...
The present study characterized cytochrome P4501A (CYP1A) isoforms from common cormorant (Phalacrocorax carbo) with regard to their evolutionary relationships and roles in disposition of dioxin related compounds (DRCs). Two clones isolated a liver cDNA library were named CYP1A4 CYP1A5 on the basis greatest overall amino acid identity shared chicken (Gallus gallus) (78%) (78%), respectively. Spatial heterogeneity phylogenetic signal along sequences strongly indicated that have undergone...
To investigate the biological effects of perfluorochemicals (PFCs) and to identify biomarkers exposure PFCs, this study focused on mediated by peroxisome proliferator-activated receptor α (PPARα) in Baikal seals (Pusa sibirica). We cloned a full-length cDNA, encoding PPARα from liver seal, which has deduced open reading frame 468-amino acid residues with predicted molecular mass 52.2 kDa. Comparison amino-acid sequence seal that other mammalian showed considerable similarities dog (97%),...
The aryl hydrocarbon receptor (AHR) mediates toxic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxin-like compounds (DLCs). Avian species possess multiple AHR isoforms (AHR1, AHR1β, AHR2) that exhibit species- isoform-specific ligands. To account for the ligand preference in terms of structural features avian AHRs, we generated silico homology models ligand-binding domain AHRs based on holo human HIF-2α (PDB entry 3H7W). Molecular docking simulations TCDD DLCs with...
The objective of this study was to assess the thyroid hormone disruption and reproductive dysfunction effects bioaccumulation rate mechanism in zebrafish exposed tris(1,3-dichloro-2-propyl) phosphate (TDCPP), with stress responsiveness. fish were test concentrations TDCPP (0, 0.06, 0.3, 1.5 µg/mL) for 21 days, accordance no observed adverse effect level (i.e., < EC10) embryos. found be significantly higher female zebrafish, while metabolic male at all studied. (triiodothyronine [T3]...
This study attempts to relate the 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalent (TEQ) level with certain responses including catalytic activities and expression of hepatic cytochrome P450 (CYP) 1A CYP1B in wild population Baikal seal (Pusa sibirica). We isolated full-length CYP1A1, 1A2, 1B1 cDNAs, which encode proteins 516, 512, 543 amino acids, respectively. Immunochemical analysis demonstrated that a cross-reactive protein polyclonal antibody against rat CYP1A1 or CYP1B1 was...