A5031442093- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Viral Infections and Immunology Research
- Antimicrobial Resistance in Staphylococcus
- Cancer Immunotherapy and Biomarkers
- Biochemical and Molecular Research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Bacterial biofilms and quorum sensing
- Acute Myeloid Leukemia Research
- Animal Disease Management and Epidemiology
- CRISPR and Genetic Engineering
- Transplantation: Methods and Outcomes
- Kruppel-like factors research
- Bacteriophages and microbial interactions
East Carolina University
2023-2025
Beijing Electronic Science and Technology Institute
2024
New York Medical College
2014-2023
Westchester Medical Center
2007-2018
Hainan Meteorological Service
2013
Jiangsu University of Technology
2008-2010
Yong In University
2010
Maria Fareri Children's Hospital
2007
Nagasaki University
1998
Pseudomonas aeruginosa (P. aeruginosa) with multi-drug resistance (MDR) is a major cause of serious healthcare-associated infections, leading to high morbidity and mortality. This opportunistic pathogen responsible for various infectious diseases, such as those seen in cystic fibrosis, ventilator-associated pneumonia, urinary tract infection, otitis externa, burn wound injuries. Due its relatively large genome, P. has great diversity can use molecular mechanisms antimicrobial resistance. For...
In 2014 the United States experienced a nationwide outbreak of Enterovirus D68 (EV-D68) infection. There were no confirmed cases EV-D68 in 2015 and CDC was only aware limited sporadic detection US 2016. this report, we analyzed 749 nasopharyngeal (NP) specimens collected 2016 from patients Lower Hudson Valley, New York using previously validated EV-D68-specific rRT-PCR assay. detected none 199 NP 2015, one 108 (0.9%) samples January to May 159 442 (36.0%) July October Complete genome...
The extended-spectrum-β-lactamase (ESBL)- and Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae represent serious urgent threats to public health. In a retrospective study of multidrug-resistant K. pneumoniae, we identified three clinical isolates, CN1, CR14, NY9, carrying both blaCTX-M blaKPC genes. complete genomes these isolates were de novo assembled by using short- long-read whole-genome sequencing. CR14 carried on two different plasmids. contrast, CN1 had one copy...
An improved fuzzy c-means algorithm is put forward and applied to deal with meteorological data on top of the traditional algorithm.The proposed improves classical (FCM) by adopting a novel strategy for selecting initial cluster centers, solve problem that clustering has difficulty in centers.Furthermore, this paper introduces features mining process open source platform WEKA, while it doesn't implement FCM algorithm.Considering shortcoming we successfully advanced taking advantage basic...
We recently identified a novel vancomycin-resistant Enterococcus faecium (VREfm) clone ST736 with reduced daptomycin susceptibility. The objectives of this study were to assess the population dynamics local VREfm strains and genetic alterations predisposing resistance in strains. Multilocus sequence typing single nucleotide variant data derived from whole-genome sequencing 250 E. isolates 1994–1995 (n = 43), 2009–2012 115) 2013 92). A remarkable change was noticed clonality antimicrobial...
// Sanghoon Lee 1, 2, * , Wen Luo Tishi Shah 1 Changhong Yin Timmy O'Connell 3 Tae-Hoon Chung 4 Sherrie L. Perkins 5 Rodney R. Miles Janet Ayello Erin Morris Lauren Harrison Carmella van de Ven Mitchell S. Cairo 3, 6, 7 Departments of Pediatrics, New York Medical College, Valhalla, York, USA 2 Cell Biology and Anatomy, Microbiology Immunology, Cancer Science Institute Singapore, National University Singapore Department Pathology ARUP Laboratories, Utah, Salt Lake City, 6 Pathology, Medicine,...
Enterovirus D68 (EV-D68) infection has been associated with outbreaks of severe respiratory illness and increased cases nonpolio acute flaccid myelitis. The patterns EV-D68 circulation molecular epidemiology are not fully understood. In this study, nasopharyngeal (NP) specimens collected from patients in the Lower Hudson Valley, New York, 2014 to 2018 were examined for rhinovirus/enterovirus (RhV/EV) by FilmArray panel. Selected RhV/EV-positive NP analyzed using two EV-D68-specific real-time...
The recent increase in Group A
ABSTRACT ArfGAP with dual PH domain‐containing protein 1 (ADAP1), also known as Centaurin alpha‐1 (CentA1), is an actin‐binding highly expressed in the central nervous system (CNS) that was previously shown to regulate dendritic spine density and plasticity. In context of disease, ADAP1/CentA1 has been linked Alzheimer's disease (AD) pathogenesis, cancer progression, human immunodeficiency virus (HIV) reactivation. Here, we document mechanistically involved CNS autoimmunity. We show...
Inappropriate activation of JAK/STAT signaling occurs with high frequency in human cancers and is associated cancer cell survival proliferation. Therefore, the development pharmacologic STAT inhibitors has therapeutic potential treatment cancers. Here, we report 2-[(3,5-bis-trifluoromethyl-phenyl)-hydroxy-methyl]-1-(4-nitro-phenylamino)-6-phenyl-1,2,4a,7a-tetrahydro-pyrrolo[3,4-b]-pyridine-5,7-dione (AUH-6-96) as a novel small-molecule inhibitor that initially identified through cell-based...
In order to identify Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling inhibitors, a cell-based high throughput screening was performed using plant extract library that identified Nb-(alpha-hydroxynaphthoyl)serotonin called MS-1020 as novel JAK3 inhibitor. potently inhibited persistently-active STAT3 in cell type-specific manner. Further examination showed selectively blocked constitutively-active consistently suppressed interleukin-2-induced JAK3/STAT5 but...
Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents. Bruton's tyrosine kinase (BTK) is activated following B-cell receptor stimulation in part regulates normal development. Ibrutinib, a selective irreversible BTK inhibitor, has been efficacious chronic lymphocytic leukemia (CLL), mantle cell (MCL), Waldenström's macroglobulinemia, marginal zone lymphoma. In this study, we investigated...
Many cytokines associated with autoimmune disorders and inflammation have been shown to activate the signalling kinase JAK3, implying that JAK3 plays key roles in pathogenesis of these diseases. Therefore, investigating alterations activity efficacy selective antagonists animal models such is essential a better understanding biology assess potential clinical benefits inhibitors.Through high-throughput cell-based screening using NCI compound library, we identified NSC163088 (berberine...
// Sanghoon Lee 1, 2, * , Tishi Shah Changhong Yin 1 Jessica Hochberg Janet Ayello Erin Morris Carmella van de Ven and Mitchell S. Cairo 3 Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA 2 Cell Biology Anatomy, Medicine, Pathology, Microbiology Immunology These authors contributed equally to this work Correspondence to: Cairo, email: mitchell_cairo@nymc.edu Keywords: ruxolitinib; survival; Hodgkin lymphoma; primary mediastinal B-cell lymphoma Received: November...
ABSTRACT We report here the incidental detection and complete genome sequence of a urinary Escherichia coli strain harboring mcr-1 resistant to colistin in New York patient returning from Portugal 2016. This strain, with type 1485 (ST1485), was non-extended-spectrum beta-lactamase (ESBL) non-carbapenemase producer carried gene on an IncHI2 plasmid.
// Puja Khanna 1 , Pei Jou Chua Belinda Shu Ee Wong Changhong Yin 2 Aye Thike 3 Wei Keat Wan 3, 4 Puay Hoon Tan and Gyeong Hun Baeg Department of Anatomy, Yong Loo Lin School Medicine, National University Singapore, Singapore 117594, Pediatrics, New York Medical College, Valhalla, NY 10595, USA Division Pathology, General Hospital, 169856, Academic Clinical Program for Duke-NUS Graduate School, 169857, Correspondence to: Baeg, email: antbgh@nus.edu.sg Keywords: JAK/STAT signaling; GRAMD1B;...
Children with acute lymphoblastic leukemia (ALL) have an 80% chance of long-term survival. Despite the high rate cure, children relapse, and recurrent ALL is difficult to cure chemotherapeutic regimens. Therefore, improved biological understanding development rationally designed therapeutics targeting molecules associated pathogenesis are essential. We identified missense synonymous JAK3 mutations in 16 91 pediatric patients ALL. The expression JAK3(V722I) mutant caused cytokine-independent...
Multidrug-resistant (MDR) Pseudomonas aeruginosa is one of the main causes morbidity and mortality in hospitalized patients leading cause nosocomial infections. We investigated, here, two MDR P. clinical isolates from a patient with differential antimicrobial resistance to ceftazidime/avibactam (CZA), ceftolozane/tazobactam (C/T), piperacillin/tazobactam (P/T). Their assembled complete genomes revealed they belonged ST235, widespread clone; were isogenic only single nucleotide variant,...