An injectable hydrogel was applied to regenerate a myocardial infarction and functional recovery of the heart. A induced in rat by circumflex artery ligation. hyaluronic acid-based injected into epicardium infarcted area. Then, cardiac functions regeneration myocardium sham-operated (SHAM), (MI), gel-injected group (GEL) (n = 6) were evaluated 4 weeks after injection. Measurements thickness wall showed that GEL increased up 200% compared with MI (p < 0.001). The area left ventricular...

Small intestinal bacterial overgrowth (SIBO) is expected in postgastrectomy patients; however, its role has not been clarified. This study was to estimate the prevalence of SIBO and investigate clinical patients.This prospective involved 76 patients who underwent gastrectomy for early gastric cancer with no evidence recurrence. An H(2)-CH(4) breath test oral glucose challenge performed diagnose dumping syndrome. Sigstad questionnaires, serum glucose, hematocrit pulse rate were simultaneously...

Remote ischemic preconditioning (RIPC) and postconditioning (RpostC) have protective effects on ischemia reperfusion injury. The been reported to activate heme oxygenase-1 (HO-1) attenuate nuclear factor kappa B (NF-κB) subsequently reduce systemic inflammation. Ischemic prevented inflammatory responses by modulating HO-1 expression in endotoxic shock model. Therefore, we investigated whether RpostC could lipopolysaccharide (LPS)-induced inflammation.The LPS-induced sepsis mice received LPS...

Atelectasis may play a substantial role in the development of pneumonia. However, pneumonia has never been evaluated as an outcome atelectasis surgical patients. We aimed to determine whether is related increased risk postoperative pneumonia, intensive care unit (ICU) admission and hospital length stay (LOS).The electronic medical records adult patients who underwent elective non-cardiothoracic surgery under general anesthesia between October 2019 August 2020 were reviewed. They divided into...

Abstract This study seeks to improve the mechanical performance of stents by conducting reliability testing and finite element method ( FEM )‐based simulations for coronary stents. Three commercially available stent designs our own new design were tested measure factors affecting performance, specifically foreshortening, recoil, radial force, flexibility. The used in present experiments 3 mm working diameter 18 length. results indicate that foreshortening A, B, C, design, D, was equivalent...

Objectives In an effort to clarify the mass intoxication of workers at electronic company in Korea, possible causative chemical for reproductive toxicity, 2-bromopropane (2BP), was investigated. Methods 2BP tested through use repeated dose experiments among male Sprague Dawley rats. Ten rats were assigned each treatment group. Vehicle control olive oil and concentrations 125 mg/kg, 250 500 mg/kg injected into intraperitoneum on 28 consecutive days. Results The showed significant decreases...

Background: Hemorheologic factors such as red blood cell (RBC) aggregation and deformability differ according to species. In many comparative hemorheologic studies, only venous samples have been used for measurements. There is little published

Extracorporeal circulation (ECC) can induce alterations in blood viscoelasticity and cause red cell (RBC) aggregation. In this study, the authors evaluated effects of pump flow pulsatility on RBC aggregation.Mongrel dogs were randomly assigned to two groups: a nonpulsatile group (n=6) or pulsatile (n=6). After ECC was started at rate 80 mL/kg/min, cardiac fibrillation induced. Blood sampling performed before 1, 2, 3 hours after commencement. To eliminate bias induced by hematocrit plasma,...

The Twin-Pulse Life Support System (T-PLS) is a novel pulsatile extracorporeal life support system developed in Korea. It has been reported that the T-PLS achieves higher levels of tissue perfusion kidney during short-term circulation and provides more blood flow to coronary artery than nonpulsatile pumps. However, these results lack pulsatility quantifications thus make it hard analyze effects upon hemodynamic performance. We have adopted concepts energy, energy equivalent pressure (EEP),...

Abstract In this study, we investigated the differences between pulsatile cardiopulmonary bypass (CPB) procedure and nonpulsatile CPB in terms of their effects on hemolysis deformability red blood cells (RBCs) under various shear stress conditions. order to research deformability, four parameters—free hemoglobin (fHb) concentration, normalized index (NIH), (DI) RBCs, elongation RBCs—have been deeply investigated. For these investigations, two randomly assigned adult mongrel dog...

Among 98 patients with IgA nephritis who had protein selectivity studies performed, 54% nonselective proteinuria and the remaining 46% selective proteinuria. Patients a higher incidence of glomerulosclerosis. At end 4-year follow-up period, lower creatinine clearance, hypertension chronic renal failure when compared to Six out eleven (55%) in study nephrotic syndrome these 6 patients, 1 spontaneous remission 5 responded steroid or cyclophosphamide therapy. The did not respond In repeated,...

The inhibitory effect of propofol on platelet aggregation remains unclear, and studies the subject disagree. Furthermore, although infusions are widely used for general anesthesia as sedatives patients in intensive care units, little information is available its concentration- time-related effects aggregation. Here, authors investigated vitro propofol, at concentrations required sedation anesthesia, after 1, 2, or 3 h. Blood from healthy volunteers (n = 9) was incubated plasma 0, 4, 10 μg/mL...

Pneumoperitoneum with an intra-abdominal pressure (IAP) of 14 mmHg is known to decrease renal function. Robotic-assisted radical prostatectomy (RARP) requires IAP more than 15 for operation. Therefore, we retrospectively investigated whether patients who underwent RARP experienced insufficiency during the postoperative period (at days 7 and 30).One hundred were enrolled in this study. Preoperative serum blood urea nitrogen (BUN) creatinine (Cr) levels measured. Creatinine clearance (CrCl)...

Acute lung injury is responsible for mortality in seriously ill patients. Previous studies have shown that systemic inflammation attenuated by remote ischemic preconditioning (RIPC) via reducing nuclear factor-kappa B (NF-κB). Therefore, we investigated whether lipopolysaccharide (LPS)-induced indirect acute (ALI) can be protected RIPC.RIPC was accomplished 10 minutes of occlusion using a tourniquet on the right hind limb mice, followed reperfusion. This process repeated three times....

According to a recent meta-analysis, in patients with body mass index (BMI) ≥ 30, high fraction of inhaled oxygen (FiO2) did not increase postoperative atelectasis. However, FiO2 generally increases the risk Therefore, this study aimed evaluate effect on development atelectasis obese using modified lung ultrasound score (LUSS).Patients were assigned 4 groups: BMI 30: group A (n = 21) and B 20) normal BMI: C 22) D 21). Groups administered 100% O2 during preinduction emergence 50% anesthesia....

Background: Cerebral aneurysm coil embolization is often performed under general anesthesia to prevent patient movement and sudden high blood pressure. However, the optimal anesthetic agent remains uncertain. This study aimed determine whether maintaining with remimazolam in patients undergoing could avoid hypotension or hypertension compared sevoflurane. Methods: Thirty-three adult participated this single-blinded, randomized controlled trial. Patients Group R were induced maintained...

An extracorporeal life support system (ECLS) with a conventional membrane oxygenator requires driving force for the blood to pass through hollow fiber membranes. We hypothesized that if gravity-flow is installed in circuit, twin sacs of pulsatile ECLS (the Twin-Pulse Life Support, T-PLS) can be placed downstream oxygenator. This would increase pump output by doubling pulse rate at given pumpsetting while maintaining effective pulsatility. The purpose this study was determine optimal circuit...

We examined the pulsatility generated by an intra-aortic balloon pump/centrifugal pump (IABP/CP) combination in terms of energy equivalent pressure (EEP) and surplus hemodynamic (SHE). In five cardiac-arrested pigs, outflow cannula CP was inserted into ascending aorta, inflow right atrium. A 30-ml IABP subsequently placed descending aorta. Extracorporeal circulation maintained for 30 minutes using a flow 75 ml/kg per minute alone or IABP/CP with measured internal carotid artery. The...